node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Il12rb1 | Map4 | ENSMUSP00000000808 | ENSMUSP00000035055 | Interleukin-12 receptor subunit beta-1; Functions as an interleukin receptor which binds interleukin- 12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade; Belongs to the type I cytokine receptor family. Type 2 subfamily. | Microtubule-associated protein 4; Non-neuronal microtubule-associated protein. Promotes microtubule assembly. | 0.425 |
Map1a | Map1b | ENSMUSP00000092223 | ENSMUSP00000068374 | Microtubule-associated protein 1A; Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements; Belongs to the MAP1 family. | Microtubule-associated protein 1B; Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1- mediated autophagic vesicle formation and membrane blebbing (By similarity). Facilitates tyrosination of alpha-tubulin in neuronal microtubules. Required for synaptic maturation. | 0.425 |
Map1a | Map4 | ENSMUSP00000092223 | ENSMUSP00000035055 | Microtubule-associated protein 1A; Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements; Belongs to the MAP1 family. | Microtubule-associated protein 4; Non-neuronal microtubule-associated protein. Promotes microtubule assembly. | 0.414 |
Map1b | Map1a | ENSMUSP00000068374 | ENSMUSP00000092223 | Microtubule-associated protein 1B; Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1- mediated autophagic vesicle formation and membrane blebbing (By similarity). Facilitates tyrosination of alpha-tubulin in neuronal microtubules. Required for synaptic maturation. | Microtubule-associated protein 1A; Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements; Belongs to the MAP1 family. | 0.425 |
Map1b | Map4 | ENSMUSP00000068374 | ENSMUSP00000035055 | Microtubule-associated protein 1B; Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1- mediated autophagic vesicle formation and membrane blebbing (By similarity). Facilitates tyrosination of alpha-tubulin in neuronal microtubules. Required for synaptic maturation. | Microtubule-associated protein 4; Non-neuronal microtubule-associated protein. Promotes microtubule assembly. | 0.475 |
Map1b | Stmn1 | ENSMUSP00000068374 | ENSMUSP00000030636 | Microtubule-associated protein 1B; Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1- mediated autophagic vesicle formation and membrane blebbing (By similarity). Facilitates tyrosination of alpha-tubulin in neuronal microtubules. Required for synaptic maturation. | Stathmin; Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis (By similarity). Involved in the control of the learned and innate fear. | 0.481 |
Map4 | Il12rb1 | ENSMUSP00000035055 | ENSMUSP00000000808 | Microtubule-associated protein 4; Non-neuronal microtubule-associated protein. Promotes microtubule assembly. | Interleukin-12 receptor subunit beta-1; Functions as an interleukin receptor which binds interleukin- 12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade; Belongs to the type I cytokine receptor family. Type 2 subfamily. | 0.425 |
Map4 | Map1a | ENSMUSP00000035055 | ENSMUSP00000092223 | Microtubule-associated protein 4; Non-neuronal microtubule-associated protein. Promotes microtubule assembly. | Microtubule-associated protein 1A; Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements; Belongs to the MAP1 family. | 0.414 |
Map4 | Map1b | ENSMUSP00000035055 | ENSMUSP00000068374 | Microtubule-associated protein 4; Non-neuronal microtubule-associated protein. Promotes microtubule assembly. | Microtubule-associated protein 1B; Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1- mediated autophagic vesicle formation and membrane blebbing (By similarity). Facilitates tyrosination of alpha-tubulin in neuronal microtubules. Required for synaptic maturation. | 0.475 |
Map4 | Mark1 | ENSMUSP00000035055 | ENSMUSP00000027929 | Microtubule-associated protein 4; Non-neuronal microtubule-associated protein. Promotes microtubule assembly. | Serine/threonine-protein kinase MARK1; Serine/threonine-protein kinase (By similarity). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (By similarity). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by p [...] | 0.434 |
Map4 | Sept2 | ENSMUSP00000035055 | ENSMUSP00000027495 | Microtubule-associated protein 4; Non-neuronal microtubule-associated protein. Promotes microtubule assembly. | Septin-2; Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar- shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis [...] | 0.656 |
Map4 | Sept2-2 | ENSMUSP00000035055 | ENSMUSP00000132850 | Microtubule-associated protein 4; Non-neuronal microtubule-associated protein. Promotes microtubule assembly. | Septin 2. | 0.656 |
Map4 | Sept7 | ENSMUSP00000035055 | ENSMUSP00000127641 | Microtubule-associated protein 4; Non-neuronal microtubule-associated protein. Promotes microtubule assembly. | Septin-7; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). | 0.481 |
Map4 | Stmn1 | ENSMUSP00000035055 | ENSMUSP00000030636 | Microtubule-associated protein 4; Non-neuronal microtubule-associated protein. Promotes microtubule assembly. | Stathmin; Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis (By similarity). Involved in the control of the learned and innate fear. | 0.484 |
Map4 | Svbp | ENSMUSP00000035055 | ENSMUSP00000095518 | Microtubule-associated protein 4; Non-neuronal microtubule-associated protein. Promotes microtubule assembly. | Small vasohibin-binding protein; Enhances the tyrosine carboxypeptidase activity of VASH1 and VASH2, thereby promoting the removal of the C-terminal tyrosine residue of alpha-tubulin. Also required to enhance the solubility and secretion of VASH1 and VASH2 (By similarity). Plays a role in axon and excitatory synapse formation. Belongs to the SVBP family. | 0.468 |
Map4 | Tuba1a | ENSMUSP00000035055 | ENSMUSP00000094778 | Microtubule-associated protein 4; Non-neuronal microtubule-associated protein. Promotes microtubule assembly. | Detyrosinated tubulin alpha-1A chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. | 0.443 |
Mark1 | Map4 | ENSMUSP00000027929 | ENSMUSP00000035055 | Serine/threonine-protein kinase MARK1; Serine/threonine-protein kinase (By similarity). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (By similarity). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by p [...] | Microtubule-associated protein 4; Non-neuronal microtubule-associated protein. Promotes microtubule assembly. | 0.434 |
Sept2 | Map4 | ENSMUSP00000027495 | ENSMUSP00000035055 | Septin-2; Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar- shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis [...] | Microtubule-associated protein 4; Non-neuronal microtubule-associated protein. Promotes microtubule assembly. | 0.656 |
Sept2 | Sept2-2 | ENSMUSP00000027495 | ENSMUSP00000132850 | Septin-2; Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar- shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis [...] | Septin 2. | 0.993 |
Sept2 | Sept7 | ENSMUSP00000027495 | ENSMUSP00000127641 | Septin-2; Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar- shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis [...] | Septin-7; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). | 0.998 |