Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Doc2a | Hirip3 | ENSMUSP00000070119 | ENSMUSP00000035535 | Double C2-like domain-containing protein alpha; Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. | HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. | 0.501 |
| Doc2a | Ino80e | ENSMUSP00000070119 | ENSMUSP00000049851 | Double C2-like domain-containing protein alpha; Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. | INO80 complex subunit E. | 0.575 |
| Doc2a | Kctd13 | ENSMUSP00000070119 | ENSMUSP00000032924 | Double C2-like domain-containing protein alpha; Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission. The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and promoting synaptic transmission ; Belongs to the BACURD family. | 0.687 |
| Doc2a | Kif22 | ENSMUSP00000070119 | ENSMUSP00000032915 | Double C2-like domain-containing protein alpha; Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. | Kinesin-like protein KIF22; Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.552 |
| Doc2a | Maz | ENSMUSP00000070119 | ENSMUSP00000032916 | Double C2-like domain-containing protein alpha; Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. | Myc-associated zinc finger protein; Transcriptional activator that binds to purine-rich GAGA sites found in the promoter of many genes including insulin I and II and islet amyloid polypeptide. | 0.478 |
| Doc2a | Taok2 | ENSMUSP00000070119 | ENSMUSP00000112963 | Double C2-like domain-containing protein alpha; Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. | Serine/threonine-protein kinase TAO2; Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress- activated MAPK cascade, pro [...] | 0.560 |
| Dusp1 | Hirip3 | ENSMUSP00000025025 | ENSMUSP00000035535 | Dual specificity protein phosphatase 1; Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. | 0.470 |
| Dusp4 | Hirip3 | ENSMUSP00000033930 | ENSMUSP00000035535 | Dual specificity protein phosphatase 4; Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. | HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. | 0.483 |
| Dusp9 | Hirip3 | ENSMUSP00000019701 | ENSMUSP00000035535 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. | 0.511 |
| Gm42742 | Hirip3 | ENSMUSP00000144243 | ENSMUSP00000035535 | PAXIP1-associated glutamate-rich protein 1A; Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned. During immunoglobulin class switching in activated [...] | HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. | 0.525 |
| Gm42742 | Ino80e | ENSMUSP00000144243 | ENSMUSP00000049851 | PAXIP1-associated glutamate-rich protein 1A; Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned. During immunoglobulin class switching in activated [...] | INO80 complex subunit E. | 0.610 |
| Gm42742 | Kctd13 | ENSMUSP00000144243 | ENSMUSP00000032924 | PAXIP1-associated glutamate-rich protein 1A; Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned. During immunoglobulin class switching in activated [...] | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission. The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and promoting synaptic transmission ; Belongs to the BACURD family. | 0.492 |
| Gm42742 | Kif22 | ENSMUSP00000144243 | ENSMUSP00000032915 | PAXIP1-associated glutamate-rich protein 1A; Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned. During immunoglobulin class switching in activated [...] | Kinesin-like protein KIF22; Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. | 0.528 |
| Gm42742 | Maz | ENSMUSP00000144243 | ENSMUSP00000032916 | PAXIP1-associated glutamate-rich protein 1A; Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned. During immunoglobulin class switching in activated [...] | Myc-associated zinc finger protein; Transcriptional activator that binds to purine-rich GAGA sites found in the promoter of many genes including insulin I and II and islet amyloid polypeptide. | 0.479 |
| Hirip3 | Doc2a | ENSMUSP00000035535 | ENSMUSP00000070119 | HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. | Double C2-like domain-containing protein alpha; Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. | 0.501 |
| Hirip3 | Dusp1 | ENSMUSP00000035535 | ENSMUSP00000025025 | HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. | Dual specificity protein phosphatase 1; Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.470 |
| Hirip3 | Dusp4 | ENSMUSP00000035535 | ENSMUSP00000033930 | HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. | Dual specificity protein phosphatase 4; Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. | 0.483 |
| Hirip3 | Dusp9 | ENSMUSP00000035535 | ENSMUSP00000019701 | HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. | 0.511 |
| Hirip3 | Gm42742 | ENSMUSP00000035535 | ENSMUSP00000144243 | HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. | PAXIP1-associated glutamate-rich protein 1A; Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex. However, its function in DNA damage has been questioned. During immunoglobulin class switching in activated [...] | 0.525 |
| Hirip3 | Ino80e | ENSMUSP00000035535 | ENSMUSP00000049851 | HIRA-interacting protein 3; May play a role in chromatin function and histone metabolism via its interaction with HIRA and histones. | INO80 complex subunit E. | 0.565 |
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