node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cd37 | Cd48 | ENSMUSP00000033063 | ENSMUSP00000064241 | Leukocyte antigen CD37; Belongs to the tetraspanin (TM4SF) family. | CD48 antigen; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. | 0.444 |
Cd37 | Cd52 | ENSMUSP00000033063 | ENSMUSP00000000696 | Leukocyte antigen CD37; Belongs to the tetraspanin (TM4SF) family. | CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role. | 0.628 |
Cd37 | Cd53 | ENSMUSP00000033063 | ENSMUSP00000035781 | Leukocyte antigen CD37; Belongs to the tetraspanin (TM4SF) family. | Leukocyte surface antigen CD53; Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells. | 0.721 |
Cd37 | Cd82 | ENSMUSP00000033063 | ENSMUSP00000028644 | Leukocyte antigen CD37; Belongs to the tetraspanin (TM4SF) family. | CD82 antigen; Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway; Belongs to the tetraspanin (TM4SF) family. | 0.795 |
Cd37 | Laptm5 | ENSMUSP00000033063 | ENSMUSP00000118415 | Leukocyte antigen CD37; Belongs to the tetraspanin (TM4SF) family. | Lysosomal-associated transmembrane protein 5; May have a special functional role during embryogenesis and in adult hematopoietic cells; Belongs to the LAPTM4/LAPTM5 transporter family. | 0.536 |
Cd37 | Ptprc | ENSMUSP00000033063 | ENSMUSP00000138350 | Leukocyte antigen CD37; Belongs to the tetraspanin (TM4SF) family. | Receptor-type tyrosine-protein phosphatase C; Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity. | 0.445 |
Cd37 | Tspan32 | ENSMUSP00000033063 | ENSMUSP00000009396 | Leukocyte antigen CD37; Belongs to the tetraspanin (TM4SF) family. | Tetraspanin-32; Belongs to the tetraspanin (TM4SF) family. | 0.759 |
Cd48 | Cd37 | ENSMUSP00000064241 | ENSMUSP00000033063 | CD48 antigen; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. | Leukocyte antigen CD37; Belongs to the tetraspanin (TM4SF) family. | 0.444 |
Cd48 | Cd52 | ENSMUSP00000064241 | ENSMUSP00000000696 | CD48 antigen; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. | CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role. | 0.873 |
Cd48 | Cd53 | ENSMUSP00000064241 | ENSMUSP00000035781 | CD48 antigen; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. | Leukocyte surface antigen CD53; Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells. | 0.857 |
Cd48 | Ctss | ENSMUSP00000064241 | ENSMUSP00000015667 | CD48 antigen; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. | Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L; Belongs to the peptidase C1 family. | 0.532 |
Cd48 | Itgb2 | ENSMUSP00000064241 | ENSMUSP00000000299 | CD48 antigen; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. | Integrin beta-2; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (By similarity). Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITG [...] | 0.729 |
Cd48 | Laptm5 | ENSMUSP00000064241 | ENSMUSP00000118415 | CD48 antigen; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. | Lysosomal-associated transmembrane protein 5; May have a special functional role during embryogenesis and in adult hematopoietic cells; Belongs to the LAPTM4/LAPTM5 transporter family. | 0.625 |
Cd48 | Ptprc | ENSMUSP00000064241 | ENSMUSP00000138350 | CD48 antigen; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. | Receptor-type tyrosine-protein phosphatase C; Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity. | 0.898 |
Cd48 | Tyrobp | ENSMUSP00000064241 | ENSMUSP00000032800 | CD48 antigen; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. | TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors. TYROBP is tyrosine- phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation. Also has an inhibitory role in some cells. Non-covalently associates with activating receptors of the CD300 family to mediate cell activation [...] | 0.566 |
Cd52 | Cd37 | ENSMUSP00000000696 | ENSMUSP00000033063 | CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role. | Leukocyte antigen CD37; Belongs to the tetraspanin (TM4SF) family. | 0.628 |
Cd52 | Cd48 | ENSMUSP00000000696 | ENSMUSP00000064241 | CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role. | CD48 antigen; Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. | 0.873 |
Cd52 | Cd53 | ENSMUSP00000000696 | ENSMUSP00000035781 | CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role. | Leukocyte surface antigen CD53; Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells. | 0.778 |
Cd52 | Ctss | ENSMUSP00000000696 | ENSMUSP00000015667 | CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role. | Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L; Belongs to the peptidase C1 family. | 0.657 |
Cd52 | Itgb2 | ENSMUSP00000000696 | ENSMUSP00000000299 | CAMPATH-1 antigen; May play a role in carrying and orienting carbohydrate, as well as having a more specific role. | Integrin beta-2; Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (By similarity). Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITG [...] | 0.618 |