Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Wfdc5WAP four-disulfide core domain 5. (126 aa)    
Predicted Functional Partners:
Wfdc12
WAP four-disulfide core domain protein 12; Antibacterial protein which inhibits the growth of E.coli and S.aureus. Putative acid-stable proteinase inhibitor.
   
  
 0.873
Wfdc15b
WAP four-disulfide core domain protein 15B; Antibacterial protein which inhibits the growth of E.coli and S.aureus.
   
  
 0.699
Gpr87
G-protein coupled receptor 87; Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage (By similarity).
   
  
 0.620
Wfdc13
WAP four-disulfide core domain protein 13; Putative acid-stable proteinase inhibitor.
   
 
 0.553
Wap
Whey acidic protein; Could be a protease inhibitor. May play an important role in mammary gland development and tissue remodeling.
   
  
 0.525
Krtdap
Keratinocyte differentiation-associated protein; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis (By similarity).
   
  
 0.502
Krt78
Keratin 78; Belongs to the intermediate filament family.
   
  
 0.490
Gm94
Uncharacterized protein C5orf46 homolog.
   
  
 0.488
Il1f5
Interleukin-36 receptor antagonist protein; Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2/IL-36R and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens. May activate an anti-inflammatory signaling pathway by recru [...]
   
  
 0.480
Wfdc16
WAP four-disulfide core domain 16.
      
 0.471
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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