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Cuzd1 protein (mouse) - STRING interaction network
"Cuzd1" - CUB and zona pellucida-like domain-containing protein 1 in Mus musculus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cuzd1CUB and zona pellucida-like domain-containing protein 1; CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes (By similarity). May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells (607 aa)    
Predicted Functional Partners:
Wfdc16
WAP four-disulfide core domain 16 (111 aa)
     
   
  0.590
mCG_15095
RIKEN cDNA 2210010C04, isoform CRA_b; RIKEN cDNA 2210010C04 gene; Belongs to the peptidase S1 family (247 aa)
     
   
  0.570
Prss2
Anionic trypsin-2; Protease, serine 2 (246 aa)
     
   
  0.552
Gif
Gastric intrinsic factor; Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis (By similarity); Belongs to the eukaryotic cobalamin transport proteins family (417 aa)
       
 
  0.546
Cela3b
Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity (269 aa)
     
        0.446
Gp2
Pancreatic secretory granule membrane major glycoprotein GP2; Glycoprotein 2 (zymogen granule membrane) (534 aa)
     
   
0.440
Teddm1
Transmembrane epididymal protein 1 (305 aa)
           
  0.435
Reg1
Lithostathine-1; Might act as an inhibitor of spontaneous calcium carbonate precipitation (165 aa)
     
        0.411
Cel
Bile salt-activated lipase; Catalyzes fat and vitamin absorption. Acts in concert with pancreatic lipase and colipase for the complete digestion of dietary triglycerides (By similarity); Belongs to the type-B carboxylesterase/lipase family (599 aa)
     
   
  0.407
Serpina1f
Alpha-1-antitrypsin 1-6; Inhibitor of serine proteases; Belongs to the serpin family (411 aa)
     
   
  0.406
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus muscaris, Mus musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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