node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Akp3 | Col3a1 | ENSMUSP00000037497 | ENSMUSP00000085192 | Intestinal-type alkaline phosphatase. | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12. | 0.538 |
Akp3 | Gch1 | ENSMUSP00000037497 | ENSMUSP00000087405 | Intestinal-type alkaline phosphatase. | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence. | 0.906 |
Akp3 | Ggt5 | ENSMUSP00000037497 | ENSMUSP00000072074 | Intestinal-type alkaline phosphatase. | Glutathione hydrolase 5 heavy chain; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). | 0.634 |
Akp3 | Ggt6 | ENSMUSP00000037497 | ENSMUSP00000075773 | Intestinal-type alkaline phosphatase. | Glutathione hydrolase 6 heavy chain; Cleaves glutathione conjugates; Belongs to the gamma-glutamyltransferase family. | 0.699 |
Akp3 | Ggt7 | ENSMUSP00000037497 | ENSMUSP00000029131 | Intestinal-type alkaline phosphatase. | Glutathione hydrolase 7 heavy chain; Cleaves glutathione conjugates. | 0.683 |
Akp3 | Got1 | ENSMUSP00000037497 | ENSMUSP00000026196 | Intestinal-type alkaline phosphatase. | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] | 0.661 |
Akp3 | Ntpcr | ENSMUSP00000037497 | ENSMUSP00000034313 | Intestinal-type alkaline phosphatase. | Cancer-related nucleoside-triphosphatase homolog; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency (By similarity). | 0.900 |
Akp3 | Pax3 | ENSMUSP00000037497 | ENSMUSP00000004994 | Intestinal-type alkaline phosphatase. | Paired box protein Pax-3; Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 (By similarity); Belongs to the paired homeobox family. | 0.556 |
Akp3 | Pts | ENSMUSP00000037497 | ENSMUSP00000034570 | Intestinal-type alkaline phosphatase. | 6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. | 0.902 |
Akp3 | Tpk1 | ENSMUSP00000037497 | ENSMUSP00000065631 | Intestinal-type alkaline phosphatase. | Thiamin pyrophosphokinase 1; Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate. | 0.902 |
Col3a1 | Akp3 | ENSMUSP00000085192 | ENSMUSP00000037497 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12. | Intestinal-type alkaline phosphatase. | 0.538 |
Col3a1 | Pax3 | ENSMUSP00000085192 | ENSMUSP00000004994 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12. | Paired box protein Pax-3; Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 (By similarity); Belongs to the paired homeobox family. | 0.599 |
Gch1 | Akp3 | ENSMUSP00000087405 | ENSMUSP00000037497 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence. | Intestinal-type alkaline phosphatase. | 0.906 |
Gch1 | Pts | ENSMUSP00000087405 | ENSMUSP00000034570 | GTP cyclohydrolase 1; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence. | 6-pyruvoyl tetrahydrobiopterin synthase; Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. | 0.985 |
Ggt5 | Akp3 | ENSMUSP00000072074 | ENSMUSP00000037497 | Glutathione hydrolase 5 heavy chain; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). | Intestinal-type alkaline phosphatase. | 0.634 |
Ggt5 | Ggt6 | ENSMUSP00000072074 | ENSMUSP00000075773 | Glutathione hydrolase 5 heavy chain; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). | Glutathione hydrolase 6 heavy chain; Cleaves glutathione conjugates; Belongs to the gamma-glutamyltransferase family. | 0.961 |
Ggt5 | Ggt7 | ENSMUSP00000072074 | ENSMUSP00000029131 | Glutathione hydrolase 5 heavy chain; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). | Glutathione hydrolase 7 heavy chain; Cleaves glutathione conjugates. | 0.957 |
Ggt5 | Got1 | ENSMUSP00000072074 | ENSMUSP00000026196 | Glutathione hydrolase 5 heavy chain; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] | 0.463 |
Ggt6 | Akp3 | ENSMUSP00000075773 | ENSMUSP00000037497 | Glutathione hydrolase 6 heavy chain; Cleaves glutathione conjugates; Belongs to the gamma-glutamyltransferase family. | Intestinal-type alkaline phosphatase. | 0.699 |
Ggt6 | Ggt5 | ENSMUSP00000075773 | ENSMUSP00000072074 | Glutathione hydrolase 6 heavy chain; Cleaves glutathione conjugates; Belongs to the gamma-glutamyltransferase family. | Glutathione hydrolase 5 heavy chain; Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). | 0.961 |