node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aldh18a1 | Letmd1 | ENSMUSP00000025979 | ENSMUSP00000037546 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53. | 0.428 |
Arid1b | Letmd1 | ENSMUSP00000111463 | ENSMUSP00000037546 | AT-rich interactive domain-containing protein 1B; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/ [...] | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53. | 0.468 |
Arid1b | Smarcc2 | ENSMUSP00000111463 | ENSMUSP00000100868 | AT-rich interactive domain-containing protein 1B; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/ [...] | SWI/SNF complex subunit SMARCC2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-s [...] | 0.998 |
Csdc2 | Letmd1 | ENSMUSP00000044441 | ENSMUSP00000037546 | Cold shock domain-containing protein C2; RNA-binding factor which binds specifically to the very 3'- UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity). | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53. | 0.429 |
Eif2d | Letmd1 | ENSMUSP00000063894 | ENSMUSP00000037546 | Eukaryotic translation initiation factor 2D; Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its [...] | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53. | 0.506 |
Hdhd2 | Letmd1 | ENSMUSP00000095129 | ENSMUSP00000037546 | Haloacid dehalogenase-like hydrolase domain-containing protein 2; Belongs to the HAD-like hydrolase superfamily. | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53. | 0.407 |
Letmd1 | Aldh18a1 | ENSMUSP00000037546 | ENSMUSP00000025979 | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53. | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.428 |
Letmd1 | Arid1b | ENSMUSP00000037546 | ENSMUSP00000111463 | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53. | AT-rich interactive domain-containing protein 1B; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/ [...] | 0.468 |
Letmd1 | Csdc2 | ENSMUSP00000037546 | ENSMUSP00000044441 | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53. | Cold shock domain-containing protein C2; RNA-binding factor which binds specifically to the very 3'- UTR ends of both histone H1 and H3.3 mRNAs, encompassing the polyadenylation signal. Might play a central role in the negative regulation of histone variant synthesis in the developing brain (By similarity). | 0.429 |
Letmd1 | Eif2d | ENSMUSP00000037546 | ENSMUSP00000063894 | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53. | Eukaryotic translation initiation factor 2D; Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its [...] | 0.506 |
Letmd1 | Hdhd2 | ENSMUSP00000037546 | ENSMUSP00000095129 | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53. | Haloacid dehalogenase-like hydrolase domain-containing protein 2; Belongs to the HAD-like hydrolase superfamily. | 0.407 |
Letmd1 | Lmbr1 | ENSMUSP00000037546 | ENSMUSP00000058405 | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53. | Limb region 1 protein; Putative membrane receptor. | 0.545 |
Letmd1 | Pja2 | ENSMUSP00000037546 | ENSMUSP00000134380 | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53. | E3 ubiquitin-protein ligase Praja-2; Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype. | 0.406 |
Letmd1 | Smarcc2 | ENSMUSP00000037546 | ENSMUSP00000100868 | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53. | SWI/SNF complex subunit SMARCC2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-s [...] | 0.558 |
Letmd1 | Ubxn1 | ENSMUSP00000037546 | ENSMUSP00000157971 | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53. | UBX domain-containing protein 1; Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling. Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibi [...] | 0.461 |
Lmbr1 | Letmd1 | ENSMUSP00000058405 | ENSMUSP00000037546 | Limb region 1 protein; Putative membrane receptor. | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53. | 0.545 |
Pja2 | Letmd1 | ENSMUSP00000134380 | ENSMUSP00000037546 | E3 ubiquitin-protein ligase Praja-2; Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype. | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53. | 0.406 |
Smarcc2 | Arid1b | ENSMUSP00000100868 | ENSMUSP00000111463 | SWI/SNF complex subunit SMARCC2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-s [...] | AT-rich interactive domain-containing protein 1B; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/ [...] | 0.998 |
Smarcc2 | Letmd1 | ENSMUSP00000100868 | ENSMUSP00000037546 | SWI/SNF complex subunit SMARCC2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-s [...] | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53. | 0.558 |
Ubxn1 | Letmd1 | ENSMUSP00000157971 | ENSMUSP00000037546 | UBX domain-containing protein 1; Ubiquitin-binding protein that plays a role in the modulation of innate immune response. Blocks both the RIG-I-like receptors (RLR) and NF-kappa-B pathways. Following viral infection, UBXN1 is induced and recruited to the RLR component MAVS. In turn, interferes with MAVS oligomerization, and disrupts the MAVS/TRAF3/TRAF6 signalosome. This function probably serves as a brake to prevent excessive RLR signaling. Interferes with the TNFalpha-triggered NF-kappa-B pathway by interacting with cellular inhibitors of apoptosis proteins (cIAPs) and thereby inhibi [...] | LETM1 domain-containing protein 1; Involved in tumorigenesis and may function as a negative regulator of the p53/TP53. | 0.461 |