node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ankmy2 | Bzw2 | ENSMUSP00000039484 | ENSMUSP00000020856 | Ankyrin repeat and MYND domain-containing protein 2; May be involved in the trafficking of signaling proteins to the cilia. | Basic leucine zipper and W2 domain-containing protein 2; May be involved in neuronal differentiation. | 0.663 |
Ankmy2 | Snx13 | ENSMUSP00000039484 | ENSMUSP00000038430 | Ankyrin repeat and MYND domain-containing protein 2; May be involved in the trafficking of signaling proteins to the cilia. | Sorting nexin-13; May be involved in several stages of intracellular trafficking. Acts as a GAP for Galphas (By similarity). May play a role in endosome homeostasis; Belongs to the sorting nexin family. | 0.664 |
Bzw2 | Ankmy2 | ENSMUSP00000020856 | ENSMUSP00000039484 | Basic leucine zipper and W2 domain-containing protein 2; May be involved in neuronal differentiation. | Ankyrin repeat and MYND domain-containing protein 2; May be involved in the trafficking of signaling proteins to the cilia. | 0.663 |
Bzw2 | Snx13 | ENSMUSP00000020856 | ENSMUSP00000038430 | Basic leucine zipper and W2 domain-containing protein 2; May be involved in neuronal differentiation. | Sorting nexin-13; May be involved in several stages of intracellular trafficking. Acts as a GAP for Galphas (By similarity). May play a role in endosome homeostasis; Belongs to the sorting nexin family. | 0.561 |
Fn3k | Snx13 | ENSMUSP00000026175 | ENSMUSP00000038430 | Fructosamine-3-kinase; Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate. Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (By similarity). Involved in intracellular deglycation in erythrocytes and pancreatic islets. Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function. Also able to phosphorylate psicosamines and ribulosamines (By similarity). | Sorting nexin-13; May be involved in several stages of intracellular trafficking. Acts as a GAP for Galphas (By similarity). May play a role in endosome homeostasis; Belongs to the sorting nexin family. | 0.724 |
Mdm1 | Snx13 | ENSMUSP00000127919 | ENSMUSP00000038430 | Nuclear protein MDM1; Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules. Belongs to the MDM1 family. | Sorting nexin-13; May be involved in several stages of intracellular trafficking. Acts as a GAP for Galphas (By similarity). May play a role in endosome homeostasis; Belongs to the sorting nexin family. | 0.611 |
Mdm1 | Snx14 | ENSMUSP00000127919 | ENSMUSP00000130116 | Nuclear protein MDM1; Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules. Belongs to the MDM1 family. | Sorting nexin-14; Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking. Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes. Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity). Belongs to the sorting nexin family. | 0.655 |
Rgs21 | Snx13 | ENSMUSP00000139265 | ENSMUSP00000038430 | Regulator of G-protein signalling 21. | Sorting nexin-13; May be involved in several stages of intracellular trafficking. Acts as a GAP for Galphas (By similarity). May play a role in endosome homeostasis; Belongs to the sorting nexin family. | 0.546 |
Snx13 | Ankmy2 | ENSMUSP00000038430 | ENSMUSP00000039484 | Sorting nexin-13; May be involved in several stages of intracellular trafficking. Acts as a GAP for Galphas (By similarity). May play a role in endosome homeostasis; Belongs to the sorting nexin family. | Ankyrin repeat and MYND domain-containing protein 2; May be involved in the trafficking of signaling proteins to the cilia. | 0.664 |
Snx13 | Bzw2 | ENSMUSP00000038430 | ENSMUSP00000020856 | Sorting nexin-13; May be involved in several stages of intracellular trafficking. Acts as a GAP for Galphas (By similarity). May play a role in endosome homeostasis; Belongs to the sorting nexin family. | Basic leucine zipper and W2 domain-containing protein 2; May be involved in neuronal differentiation. | 0.561 |
Snx13 | Fn3k | ENSMUSP00000038430 | ENSMUSP00000026175 | Sorting nexin-13; May be involved in several stages of intracellular trafficking. Acts as a GAP for Galphas (By similarity). May play a role in endosome homeostasis; Belongs to the sorting nexin family. | Fructosamine-3-kinase; Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate. Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (By similarity). Involved in intracellular deglycation in erythrocytes and pancreatic islets. Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function. Also able to phosphorylate psicosamines and ribulosamines (By similarity). | 0.724 |
Snx13 | Mdm1 | ENSMUSP00000038430 | ENSMUSP00000127919 | Sorting nexin-13; May be involved in several stages of intracellular trafficking. Acts as a GAP for Galphas (By similarity). May play a role in endosome homeostasis; Belongs to the sorting nexin family. | Nuclear protein MDM1; Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules. Belongs to the MDM1 family. | 0.611 |
Snx13 | Rgs21 | ENSMUSP00000038430 | ENSMUSP00000139265 | Sorting nexin-13; May be involved in several stages of intracellular trafficking. Acts as a GAP for Galphas (By similarity). May play a role in endosome homeostasis; Belongs to the sorting nexin family. | Regulator of G-protein signalling 21. | 0.546 |
Snx13 | Snx14 | ENSMUSP00000038430 | ENSMUSP00000130116 | Sorting nexin-13; May be involved in several stages of intracellular trafficking. Acts as a GAP for Galphas (By similarity). May play a role in endosome homeostasis; Belongs to the sorting nexin family. | Sorting nexin-14; Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking. Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes. Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity). Belongs to the sorting nexin family. | 0.743 |
Snx13 | Snx17 | ENSMUSP00000038430 | ENSMUSP00000031029 | Sorting nexin-13; May be involved in several stages of intracellular trafficking. Acts as a GAP for Galphas (By similarity). May play a role in endosome homeostasis; Belongs to the sorting nexin family. | Sorting nexin-17; Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos (By similarity). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (By similarity). Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (Ptd [...] | 0.641 |
Snx13 | Snx2 | ENSMUSP00000038430 | ENSMUSP00000039243 | Sorting nexin-13; May be involved in several stages of intracellular trafficking. Acts as a GAP for Galphas (By similarity). May play a role in endosome homeostasis; Belongs to the sorting nexin family. | Sorting nexin-2; Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called en [...] | 0.589 |
Snx13 | Snx27 | ENSMUSP00000038430 | ENSMUSP00000102904 | Sorting nexin-13; May be involved in several stages of intracellular trafficking. Acts as a GAP for Galphas (By similarity). May play a role in endosome homeostasis; Belongs to the sorting nexin family. | Sorting nexin-27; Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C- terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing e [...] | 0.595 |
Snx13 | Snx3 | ENSMUSP00000038430 | ENSMUSP00000019939 | Sorting nexin-13; May be involved in several stages of intracellular trafficking. Acts as a GAP for Galphas (By similarity). May play a role in endosome homeostasis; Belongs to the sorting nexin family. | Sorting nexin-3; Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Also can bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC). May act in part as component of the SNX3-retromer complex which mediates the retrograde en [...] | 0.570 |
Snx14 | Mdm1 | ENSMUSP00000130116 | ENSMUSP00000127919 | Sorting nexin-14; Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking. Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes. Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity). Belongs to the sorting nexin family. | Nuclear protein MDM1; Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules. Belongs to the MDM1 family. | 0.655 |
Snx14 | Snx13 | ENSMUSP00000130116 | ENSMUSP00000038430 | Sorting nexin-14; Plays a role in maintaining normal neuronal excitability and synaptic transmission. May be involved in several stages of intracellular trafficking. Required for autophagosome clearance, possibly by mediating the fusion of lysosomes with autophagosomes. Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2), a key component of late endosomes/lysosomes. Does not bind phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity). Belongs to the sorting nexin family. | Sorting nexin-13; May be involved in several stages of intracellular trafficking. Acts as a GAP for Galphas (By similarity). May play a role in endosome homeostasis; Belongs to the sorting nexin family. | 0.743 |