Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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Hmx3Homeobox protein HMX3; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS; Belongs to the HMX homeobox family. (356 aa)    
Predicted Functional Partners:
Lhx6
LIM/homeobox protein Lhx6; Probable transcription factor required for the expression of a subset of genes involved in interneurons migration and development. Functions in the specification of cortical interneuron subtypes and in the migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex.
    
 
 0.629
Pax2
Paired box protein Pax-2; Transcription factor that may have a role in kidney cell differentiation.
   
 
 0.499
Lhx8
LIM/homeobox protein Lhx8; Transcription factor involved in differentiation of certain neurons and mesenchymal cells.
   
 
 0.492
Tbx1
T-box transcription factor TBX1; Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries.
    
 
 0.472
Gm3383
Predicted gene 3194.
      
 0.456
Gm3194
Predicted gene 3194.
      
 0.456
Gm10719
Predicted gene 10719.
      
 0.439
Gm10720
Predicted gene 10720.
      
 0.439
Gm17535
Predicted gene, 17535.
      
 0.439
Ppp1r21
Protein phosphatase 1 regulatory subunit 21; utative regulator of protein phosphatase 1 (PP1) activity. May play a role in the endosomal sorting process or in endosome maturation pathway.
    
   0.432
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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