node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
1300017J02Rik | Ica1 | ENSMUSP00000035163 | ENSMUSP00000040062 | Inhibitor of carbonic anhydrase; Inhibitor for carbonic anhydrase 2 (CA2). Does not bind iron ions. | Islet cell autoantigen 1; May play a role in neurotransmitter secretion. | 0.473 |
Asap2 | Ica1 | ENSMUSP00000063217 | ENSMUSP00000040062 | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration (By similarity). | Islet cell autoantigen 1; May play a role in neurotransmitter secretion. | 0.540 |
Ccdc186 | Ica1 | ENSMUSP00000113457 | ENSMUSP00000040062 | Coiled-coil domain-containing protein 186. | Islet cell autoantigen 1; May play a role in neurotransmitter secretion. | 0.467 |
Ccdc186 | Rab2a | ENSMUSP00000113457 | ENSMUSP00000057664 | Coiled-coil domain-containing protein 186. | Ras-related protein Rab-2A; Required for protein transport from the endoplasmic reticulum to the Golgi complex. | 0.477 |
Cntn4 | Ica1 | ENSMUSP00000108889 | ENSMUSP00000040062 | Contactin-4; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis; Belongs to the immunoglobulin superfamily. Contactin family. | Islet cell autoantigen 1; May play a role in neurotransmitter secretion. | 0.482 |
Cntn4 | Nrxn1 | ENSMUSP00000108889 | ENSMUSP00000125407 | Contactin-4; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis; Belongs to the immunoglobulin superfamily. Contactin family. | Neurexin-1; Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N- terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect [...] | 0.658 |
Ica1 | 1300017J02Rik | ENSMUSP00000040062 | ENSMUSP00000035163 | Islet cell autoantigen 1; May play a role in neurotransmitter secretion. | Inhibitor of carbonic anhydrase; Inhibitor for carbonic anhydrase 2 (CA2). Does not bind iron ions. | 0.473 |
Ica1 | Asap2 | ENSMUSP00000040062 | ENSMUSP00000063217 | Islet cell autoantigen 1; May play a role in neurotransmitter secretion. | Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration (By similarity). | 0.540 |
Ica1 | Ccdc186 | ENSMUSP00000040062 | ENSMUSP00000113457 | Islet cell autoantigen 1; May play a role in neurotransmitter secretion. | Coiled-coil domain-containing protein 186. | 0.467 |
Ica1 | Cntn4 | ENSMUSP00000040062 | ENSMUSP00000108889 | Islet cell autoantigen 1; May play a role in neurotransmitter secretion. | Contactin-4; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis; Belongs to the immunoglobulin superfamily. Contactin family. | 0.482 |
Ica1 | Nrxn1 | ENSMUSP00000040062 | ENSMUSP00000125407 | Islet cell autoantigen 1; May play a role in neurotransmitter secretion. | Neurexin-1; Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N- terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect [...] | 0.454 |
Ica1 | Pick1 | ENSMUSP00000040062 | ENSMUSP00000128126 | Islet cell autoantigen 1; May play a role in neurotransmitter secretion. | PRKCA-binding protein; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive w [...] | 0.927 |
Ica1 | Pkp2 | ENSMUSP00000040062 | ENSMUSP00000036890 | Islet cell autoantigen 1; May play a role in neurotransmitter secretion. | Plakophilin 2. | 0.518 |
Ica1 | Ptprn2 | ENSMUSP00000040062 | ENSMUSP00000064046 | Islet cell autoantigen 1; May play a role in neurotransmitter secretion. | Receptor-type tyrosine-protein phosphatase N2; Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones [...] | 0.516 |
Ica1 | Rab2a | ENSMUSP00000040062 | ENSMUSP00000057664 | Islet cell autoantigen 1; May play a role in neurotransmitter secretion. | Ras-related protein Rab-2A; Required for protein transport from the endoplasmic reticulum to the Golgi complex. | 0.798 |
Ica1 | Slc30a8 | ENSMUSP00000040062 | ENSMUSP00000035257 | Islet cell autoantigen 1; May play a role in neurotransmitter secretion. | Zinc transporter 8; Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells (By similarity). | 0.488 |
Nrxn1 | Cntn4 | ENSMUSP00000125407 | ENSMUSP00000108889 | Neurexin-1; Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N- terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect [...] | Contactin-4; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis; Belongs to the immunoglobulin superfamily. Contactin family. | 0.658 |
Nrxn1 | Ica1 | ENSMUSP00000125407 | ENSMUSP00000040062 | Neurexin-1; Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N- terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect [...] | Islet cell autoantigen 1; May play a role in neurotransmitter secretion. | 0.454 |
Nrxn1 | Pick1 | ENSMUSP00000125407 | ENSMUSP00000128126 | Neurexin-1; Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N- terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect [...] | PRKCA-binding protein; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive w [...] | 0.449 |
Pick1 | Ica1 | ENSMUSP00000128126 | ENSMUSP00000040062 | PRKCA-binding protein; Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive w [...] | Islet cell autoantigen 1; May play a role in neurotransmitter secretion. | 0.927 |