node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Akr1b8 | Dcxr | ENSMUSP00000040244 | ENSMUSP00000026144 | Aldose reductase-related protein 2. | L-xylulose reductase; Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. | 0.946 |
Akr1b8 | Dhdh | ENSMUSP00000040244 | ENSMUSP00000011526 | Aldose reductase-related protein 2. | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. | 0.943 |
Akr1b8 | Dhfr | ENSMUSP00000040244 | ENSMUSP00000022218 | Aldose reductase-related protein 2. | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA. | 0.912 |
Akr1b8 | Galm | ENSMUSP00000040244 | ENSMUSP00000040580 | Aldose reductase-related protein 2. | Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity). | 0.910 |
Akr1b8 | Gk | ENSMUSP00000040244 | ENSMUSP00000109611 | Aldose reductase-related protein 2. | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. | 0.912 |
Akr1b8 | Gk2 | ENSMUSP00000040244 | ENSMUSP00000052226 | Aldose reductase-related protein 2. | Glycerol kinase 2; Key enzyme in the regulation of glycerol uptake and metabolism; Belongs to the FGGY kinase family. | 0.913 |
Akr1b8 | Gykl1 | ENSMUSP00000040244 | ENSMUSP00000067598 | Aldose reductase-related protein 2. | Glycerol kinase-like 1; Belongs to the FGGY kinase family. | 0.918 |
Akr1b8 | Qdpr | ENSMUSP00000040244 | ENSMUSP00000015950 | Aldose reductase-related protein 2. | Dihydropteridine reductase; The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.916 |
Akr1b8 | Sord | ENSMUSP00000040244 | ENSMUSP00000106180 | Aldose reductase-related protein 2. | Sorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols (By similarity). Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism (By similarity). May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility and protein tyrosine phosphorylation. Has no activity on ethanol. Cannot use N [...] | 0.952 |
Akr1b8 | Th | ENSMUSP00000040244 | ENSMUSP00000000219 | Aldose reductase-related protein 2. | Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons. | 0.920 |
Dcxr | Akr1b8 | ENSMUSP00000026144 | ENSMUSP00000040244 | L-xylulose reductase; Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. | Aldose reductase-related protein 2. | 0.946 |
Dcxr | Sord | ENSMUSP00000026144 | ENSMUSP00000106180 | L-xylulose reductase; Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. | Sorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols (By similarity). Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism (By similarity). May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility and protein tyrosine phosphorylation. Has no activity on ethanol. Cannot use N [...] | 0.932 |
Dhdh | Akr1b8 | ENSMUSP00000011526 | ENSMUSP00000040244 | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. | Aldose reductase-related protein 2. | 0.943 |
Dhdh | Sord | ENSMUSP00000011526 | ENSMUSP00000106180 | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase. | Sorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols (By similarity). Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism (By similarity). May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility and protein tyrosine phosphorylation. Has no activity on ethanol. Cannot use N [...] | 0.529 |
Dhfr | Akr1b8 | ENSMUSP00000022218 | ENSMUSP00000040244 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA. | Aldose reductase-related protein 2. | 0.912 |
Dhfr | Qdpr | ENSMUSP00000022218 | ENSMUSP00000015950 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA. | Dihydropteridine reductase; The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.966 |
Dhfr | Th | ENSMUSP00000022218 | ENSMUSP00000000219 | Dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA. | Tyrosine 3-monooxygenase; Plays an important role in the physiology of adrenergic neurons. | 0.917 |
Galm | Akr1b8 | ENSMUSP00000040580 | ENSMUSP00000040244 | Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity). | Aldose reductase-related protein 2. | 0.910 |
Galm | Sord | ENSMUSP00000040580 | ENSMUSP00000106180 | Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity). | Sorbitol dehydrogenase; Polyol dehydrogenase that catalyzes the reversible NAD(+)- dependent oxidation of various sugar alcohols (By similarity). Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism (By similarity). May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility and protein tyrosine phosphorylation. Has no activity on ethanol. Cannot use N [...] | 0.602 |
Gk | Akr1b8 | ENSMUSP00000109611 | ENSMUSP00000040244 | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. | Aldose reductase-related protein 2. | 0.912 |