node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cfap36 | Fam81b | ENSMUSP00000020754 | ENSMUSP00000146649 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | Family with sequence similarity 81, member B. | 0.582 |
Cfap36 | Vwa1 | ENSMUSP00000020754 | ENSMUSP00000040405 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | Von Willebrand factor A domain-containing protein 1; Promotes matrix assembly. | 0.504 |
Chit1 | Slc5a7 | ENSMUSP00000123979 | ENSMUSP00000093379 | Chitotriosidase-1; Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens (By similarity). Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. | High affinity choline transporter 1; Transmembrane transporter that imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | 0.409 |
Chit1 | Vwa1 | ENSMUSP00000123979 | ENSMUSP00000040405 | Chitotriosidase-1; Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens (By similarity). Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. | Von Willebrand factor A domain-containing protein 1; Promotes matrix assembly. | 0.444 |
Fam20c | Vwa1 | ENSMUSP00000026972 | ENSMUSP00000040405 | Extracellular serine/threonine protein kinase FAM20C; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (By similarity). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity (By similarity). Phosphorylates casein as well as a number of proteins involved in biomineralization such [...] | Von Willebrand factor A domain-containing protein 1; Promotes matrix assembly. | 0.566 |
Fam81b | Cfap36 | ENSMUSP00000146649 | ENSMUSP00000020754 | Family with sequence similarity 81, member B. | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | 0.582 |
Fam81b | Vwa1 | ENSMUSP00000146649 | ENSMUSP00000040405 | Family with sequence similarity 81, member B. | Von Willebrand factor A domain-containing protein 1; Promotes matrix assembly. | 0.477 |
Hspg2 | Ltbp4 | ENSMUSP00000131316 | ENSMUSP00000037536 | Basement membrane-specific heparan sulfate proteoglycan core protein; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development (By similarity). The LG3 peptide has anti-angiogenic propert [...] | Latent-transforming growth factor beta-binding protein 4; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. | 0.431 |
Hspg2 | Vwa1 | ENSMUSP00000131316 | ENSMUSP00000040405 | Basement membrane-specific heparan sulfate proteoglycan core protein; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development (By similarity). The LG3 peptide has anti-angiogenic propert [...] | Von Willebrand factor A domain-containing protein 1; Promotes matrix assembly. | 0.642 |
Ltbp4 | Hspg2 | ENSMUSP00000037536 | ENSMUSP00000131316 | Latent-transforming growth factor beta-binding protein 4; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. | Basement membrane-specific heparan sulfate proteoglycan core protein; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development (By similarity). The LG3 peptide has anti-angiogenic propert [...] | 0.431 |
Ltbp4 | Vwa1 | ENSMUSP00000037536 | ENSMUSP00000040405 | Latent-transforming growth factor beta-binding protein 4; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. | Von Willebrand factor A domain-containing protein 1; Promotes matrix assembly. | 0.477 |
Mmrn2 | Vwa1 | ENSMUSP00000107539 | ENSMUSP00000040405 | Multimerin-2; Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA. | Von Willebrand factor A domain-containing protein 1; Promotes matrix assembly. | 0.469 |
Plvap | Vwa1 | ENSMUSP00000035404 | ENSMUSP00000040405 | Plasmalemma vesicle-associated protein; Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development. | Von Willebrand factor A domain-containing protein 1; Promotes matrix assembly. | 0.474 |
Slc5a7 | Chit1 | ENSMUSP00000093379 | ENSMUSP00000123979 | High affinity choline transporter 1; Transmembrane transporter that imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | Chitotriosidase-1; Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens (By similarity). Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. | 0.409 |
Slc5a7 | Vwa1 | ENSMUSP00000093379 | ENSMUSP00000040405 | High affinity choline transporter 1; Transmembrane transporter that imports choline from the extracellular space to the neuron with high affinity. Choline uptake is the rate-limiting step in acetylcholine synthesis. Sodium ion- and chloride ion-dependent; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. | Von Willebrand factor A domain-containing protein 1; Promotes matrix assembly. | 0.441 |
Ssu72 | Vwa1 | ENSMUSP00000030905 | ENSMUSP00000040405 | RNA polymerase II subunit A C-terminal domain phosphatase SSU72; Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK; Belongs to the SSU72 phosphatase family. | Von Willebrand factor A domain-containing protein 1; Promotes matrix assembly. | 0.430 |
Vwa1 | Cfap36 | ENSMUSP00000040405 | ENSMUSP00000020754 | Von Willebrand factor A domain-containing protein 1; Promotes matrix assembly. | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family. | 0.504 |
Vwa1 | Chit1 | ENSMUSP00000040405 | ENSMUSP00000123979 | Von Willebrand factor A domain-containing protein 1; Promotes matrix assembly. | Chitotriosidase-1; Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens (By similarity). Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. | 0.444 |
Vwa1 | Fam20c | ENSMUSP00000040405 | ENSMUSP00000026972 | Von Willebrand factor A domain-containing protein 1; Promotes matrix assembly. | Extracellular serine/threonine protein kinase FAM20C; Golgi serine/threonine protein kinase that phosphorylates secretory pathway proteins within Ser-x-Glu/pSer motifs and plays a key role in biomineralization of bones and teeth. Constitutes the main protein kinase for extracellular proteins, generating the majority of the extracellular phosphoproteome (By similarity). Mainly phosphorylates proteins within the Ser-x-Glu/pSer motif, but also displays a broader substrate specificity (By similarity). Phosphorylates casein as well as a number of proteins involved in biomineralization such [...] | 0.566 |
Vwa1 | Fam81b | ENSMUSP00000040405 | ENSMUSP00000146649 | Von Willebrand factor A domain-containing protein 1; Promotes matrix assembly. | Family with sequence similarity 81, member B. | 0.477 |