node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Fgfr1op2 | Sike1 | ENSMUSP00000107292 | ENSMUSP00000029447 | FGFR1 oncogene partner 2 homolog; May be involved in wound healing pathway. | Suppressor of IKBKE 1; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3- mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways (By similarity). | 0.969 |
Fgfr1op2 | Stk24 | ENSMUSP00000107292 | ENSMUSP00000078746 | FGFR1 oncogene partner 2 homolog; May be involved in wound healing pathway. | Serine/threonine-protein kinase 24 12 kDa subunit; Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr [...] | 0.960 |
Fgfr1op2 | Stk25 | ENSMUSP00000107292 | ENSMUSP00000027498 | FGFR1 oncogene partner 2 homolog; May be involved in wound healing pathway. | Serine/threonine-protein kinase 25; Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration (By similarity). | 0.963 |
Fgfr1op2 | Stk26 | ENSMUSP00000107292 | ENSMUSP00000033444 | FGFR1 oncogene partner 2 homolog; May be involved in wound healing pathway. | Serine/threonine-protein kinase 26; Mediator of cell growth. Modulates apoptosis. In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation. | 0.708 |
Fgfr1op2 | Strip1 | ENSMUSP00000107292 | ENSMUSP00000068587 | FGFR1 oncogene partner 2 homolog; May be involved in wound healing pathway. | Striatin-interacting protein 1; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape (By similarity); Belongs to the STRIP family. | 0.974 |
Fgfr1op2 | Strip2 | ENSMUSP00000107292 | ENSMUSP00000036477 | FGFR1 oncogene partner 2 homolog; May be involved in wound healing pathway. | Striatin-interacting proteins 2; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity); Belongs to the STRIP family. | 0.851 |
Fgfr1op2 | Strn | ENSMUSP00000107292 | ENSMUSP00000120830 | FGFR1 oncogene partner 2 homolog; May be involved in wound healing pathway. | Striatin; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein; Belongs to the WD repeat striatin family. | 0.733 |
Fgfr1op2 | Strn3 | ENSMUSP00000107292 | ENSMUSP00000013130 | FGFR1 oncogene partner 2 homolog; May be involved in wound healing pathway. | Striatin-3; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein (By similarity); Belongs to the WD repeat striatin family. | 0.974 |
Fgfr1op2 | Strn4 | ENSMUSP00000107292 | ENSMUSP00000019220 | FGFR1 oncogene partner 2 homolog; May be involved in wound healing pathway. | Striatin-4; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein; Belongs to the WD repeat striatin family. | 0.716 |
Fgfr1op2 | Traf3ip3 | ENSMUSP00000107292 | ENSMUSP00000040977 | FGFR1 oncogene partner 2 homolog; May be involved in wound healing pathway. | TRAF3-interacting JNK-activating modulator; May function as an adapter molecule that regulates TRAF3- mediated JNK activation. | 0.981 |
Sike1 | Fgfr1op2 | ENSMUSP00000029447 | ENSMUSP00000107292 | Suppressor of IKBKE 1; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3- mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways (By similarity). | FGFR1 oncogene partner 2 homolog; May be involved in wound healing pathway. | 0.969 |
Sike1 | Stk24 | ENSMUSP00000029447 | ENSMUSP00000078746 | Suppressor of IKBKE 1; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3- mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways (By similarity). | Serine/threonine-protein kinase 24 12 kDa subunit; Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr [...] | 0.966 |
Sike1 | Stk25 | ENSMUSP00000029447 | ENSMUSP00000027498 | Suppressor of IKBKE 1; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3- mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways (By similarity). | Serine/threonine-protein kinase 25; Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration (By similarity). | 0.971 |
Sike1 | Stk26 | ENSMUSP00000029447 | ENSMUSP00000033444 | Suppressor of IKBKE 1; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3- mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways (By similarity). | Serine/threonine-protein kinase 26; Mediator of cell growth. Modulates apoptosis. In association with STK24 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation. | 0.821 |
Sike1 | Strip1 | ENSMUSP00000029447 | ENSMUSP00000068587 | Suppressor of IKBKE 1; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3- mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways (By similarity). | Striatin-interacting protein 1; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape (By similarity); Belongs to the STRIP family. | 0.984 |
Sike1 | Strip2 | ENSMUSP00000029447 | ENSMUSP00000036477 | Suppressor of IKBKE 1; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3- mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways (By similarity). | Striatin-interacting proteins 2; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity); Belongs to the STRIP family. | 0.987 |
Sike1 | Strn | ENSMUSP00000029447 | ENSMUSP00000120830 | Suppressor of IKBKE 1; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3- mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways (By similarity). | Striatin; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein; Belongs to the WD repeat striatin family. | 0.985 |
Sike1 | Strn3 | ENSMUSP00000029447 | ENSMUSP00000013130 | Suppressor of IKBKE 1; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3- mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways (By similarity). | Striatin-3; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein (By similarity); Belongs to the WD repeat striatin family. | 0.990 |
Sike1 | Strn4 | ENSMUSP00000029447 | ENSMUSP00000019220 | Suppressor of IKBKE 1; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3- mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways (By similarity). | Striatin-4; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein; Belongs to the WD repeat striatin family. | 0.974 |
Sike1 | Traf3ip3 | ENSMUSP00000029447 | ENSMUSP00000040977 | Suppressor of IKBKE 1; Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3- mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways (By similarity). | TRAF3-interacting JNK-activating modulator; May function as an adapter molecule that regulates TRAF3- mediated JNK activation. | 0.953 |