| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Ift122 | Serpina3g | ENSMUSP00000045468 | ENSMUSP00000041250 | Intraflagellar transport protein 122 homolog; As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is required in ciliogenesis and ciliary protein trafficking (By similarity). Involved in cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia. | Serine protease inhibitor A3G; Belongs to the serpin family. | 0.715 |
| Ift122 | Spi1 | ENSMUSP00000045468 | ENSMUSP00000002180 | Intraflagellar transport protein 122 homolog; As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is required in ciliogenesis and ciliary protein trafficking (By similarity). Involved in cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia. | Transcription factor PU.1; Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA- 3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing. | 0.611 |
| Plau | Serpina3f | ENSMUSP00000022368 | ENSMUSP00000113945 | Urokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin; Belongs to the peptidase S1 family. | Serine protease inhibitor A3F; Belongs to the serpin family. | 0.668 |
| Plau | Serpina3g | ENSMUSP00000022368 | ENSMUSP00000041250 | Urokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin; Belongs to the peptidase S1 family. | Serine protease inhibitor A3G; Belongs to the serpin family. | 0.607 |
| Plau | Serpinb2 | ENSMUSP00000022368 | ENSMUSP00000065277 | Urokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin; Belongs to the peptidase S1 family. | Plasminogen activator inhibitor 2, macrophage; Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. Not required for normal murine development or survival; Belongs to the serpin family. Ov-serpin subfamily. | 0.988 |
| Plau | Serpinc1 | ENSMUSP00000022368 | ENSMUSP00000068971 | Urokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin; Belongs to the peptidase S1 family. | Antithrombin-III; Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity). | 0.590 |
| Plau | Serpine1 | ENSMUSP00000022368 | ENSMUSP00000039586 | Urokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin; Belongs to the peptidase S1 family. | Plasminogen activator inhibitor 1; Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase- type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair (B [...] | 0.999 |
| Plau | Serpine2 | ENSMUSP00000022368 | ENSMUSP00000027467 | Urokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin; Belongs to the peptidase S1 family. | Glia-derived nexin; Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin. | 0.994 |
| Serpina3f | Plau | ENSMUSP00000113945 | ENSMUSP00000022368 | Serine protease inhibitor A3F; Belongs to the serpin family. | Urokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin; Belongs to the peptidase S1 family. | 0.668 |
| Serpina3f | Serpina3g | ENSMUSP00000113945 | ENSMUSP00000041250 | Serine protease inhibitor A3F; Belongs to the serpin family. | Serine protease inhibitor A3G; Belongs to the serpin family. | 0.770 |
| Serpina3f | Serpinb2 | ENSMUSP00000113945 | ENSMUSP00000065277 | Serine protease inhibitor A3F; Belongs to the serpin family. | Plasminogen activator inhibitor 2, macrophage; Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. Not required for normal murine development or survival; Belongs to the serpin family. Ov-serpin subfamily. | 0.600 |
| Serpina3f | Serpinc1 | ENSMUSP00000113945 | ENSMUSP00000068971 | Serine protease inhibitor A3F; Belongs to the serpin family. | Antithrombin-III; Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity). | 0.668 |
| Serpina3f | Serpind1 | ENSMUSP00000113945 | ENSMUSP00000023450 | Serine protease inhibitor A3F; Belongs to the serpin family. | Heparin cofactor 2; Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT). Also inhibits chymotrypsin, but in a glycosaminoglycan- independent manner; Belongs to the serpin family. | 0.606 |
| Serpina3f | Serpine1 | ENSMUSP00000113945 | ENSMUSP00000039586 | Serine protease inhibitor A3F; Belongs to the serpin family. | Plasminogen activator inhibitor 1; Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase- type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair (B [...] | 0.568 |
| Serpina3f | Serpine2 | ENSMUSP00000113945 | ENSMUSP00000027467 | Serine protease inhibitor A3F; Belongs to the serpin family. | Glia-derived nexin; Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin. | 0.602 |
| Serpina3g | Ift122 | ENSMUSP00000041250 | ENSMUSP00000045468 | Serine protease inhibitor A3G; Belongs to the serpin family. | Intraflagellar transport protein 122 homolog; As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is required in ciliogenesis and ciliary protein trafficking (By similarity). Involved in cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia. | 0.715 |
| Serpina3g | Plau | ENSMUSP00000041250 | ENSMUSP00000022368 | Serine protease inhibitor A3G; Belongs to the serpin family. | Urokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin; Belongs to the peptidase S1 family. | 0.607 |
| Serpina3g | Serpina3f | ENSMUSP00000041250 | ENSMUSP00000113945 | Serine protease inhibitor A3G; Belongs to the serpin family. | Serine protease inhibitor A3F; Belongs to the serpin family. | 0.770 |
| Serpina3g | Serpinb2 | ENSMUSP00000041250 | ENSMUSP00000065277 | Serine protease inhibitor A3G; Belongs to the serpin family. | Plasminogen activator inhibitor 2, macrophage; Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1. Not required for normal murine development or survival; Belongs to the serpin family. Ov-serpin subfamily. | 0.594 |
| Serpina3g | Serpinc1 | ENSMUSP00000041250 | ENSMUSP00000068971 | Serine protease inhibitor A3G; Belongs to the serpin family. | Antithrombin-III; Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity). | 0.646 |
