Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Agtr2 | Fndc3b | ENSMUSP00000086592 | ENSMUSP00000141620 | Type-2 angiotensin II receptor; Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. | Fibronectin type III domain-containing protein 3B; May be positive regulator of adipogenesis; Belongs to the FNDC3 family. | 0.494 |
| Api5 | Fndc3b | ENSMUSP00000028617 | ENSMUSP00000141620 | Apoptosis inhibitor 5; Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis (By similarity). | Fibronectin type III domain-containing protein 3B; May be positive regulator of adipogenesis; Belongs to the FNDC3 family. | 0.489 |
| Arpc1b | Fndc3b | ENSMUSP00000082822 | ENSMUSP00000141620 | Actin-related protein 2/3 complex subunit 1B; Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DN [...] | Fibronectin type III domain-containing protein 3B; May be positive regulator of adipogenesis; Belongs to the FNDC3 family. | 0.523 |
| Banp | Fndc3b | ENSMUSP00000132095 | ENSMUSP00000141620 | Protein BANP; Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest and inhibits tumor growth. | Fibronectin type III domain-containing protein 3B; May be positive regulator of adipogenesis; Belongs to the FNDC3 family. | 0.446 |
| Fndc3a | Fndc3b | ENSMUSP00000086411 | ENSMUSP00000141620 | Fibronectin type-III domain-containing protein 3A; Mediates spermatid-Sertoli adhesion during spermatogenesis. | Fibronectin type III domain-containing protein 3B; May be positive regulator of adipogenesis; Belongs to the FNDC3 family. | 0.472 |
| Fndc3b | Agtr2 | ENSMUSP00000141620 | ENSMUSP00000086592 | Fibronectin type III domain-containing protein 3B; May be positive regulator of adipogenesis; Belongs to the FNDC3 family. | Type-2 angiotensin II receptor; Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. | 0.494 |
| Fndc3b | Api5 | ENSMUSP00000141620 | ENSMUSP00000028617 | Fibronectin type III domain-containing protein 3B; May be positive regulator of adipogenesis; Belongs to the FNDC3 family. | Apoptosis inhibitor 5; Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis (By similarity). | 0.489 |
| Fndc3b | Arpc1b | ENSMUSP00000141620 | ENSMUSP00000082822 | Fibronectin type III domain-containing protein 3B; May be positive regulator of adipogenesis; Belongs to the FNDC3 family. | Actin-related protein 2/3 complex subunit 1B; Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DN [...] | 0.523 |
| Fndc3b | Banp | ENSMUSP00000141620 | ENSMUSP00000132095 | Fibronectin type III domain-containing protein 3B; May be positive regulator of adipogenesis; Belongs to the FNDC3 family. | Protein BANP; Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest and inhibits tumor growth. | 0.446 |
| Fndc3b | Fndc3a | ENSMUSP00000141620 | ENSMUSP00000086411 | Fibronectin type III domain-containing protein 3B; May be positive regulator of adipogenesis; Belongs to the FNDC3 family. | Fibronectin type-III domain-containing protein 3A; Mediates spermatid-Sertoli adhesion during spermatogenesis. | 0.472 |
| Fndc3b | Gmds | ENSMUSP00000141620 | ENSMUSP00000036696 | Fibronectin type III domain-containing protein 3B; May be positive regulator of adipogenesis; Belongs to the FNDC3 family. | GDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. | 0.496 |
| Fndc3b | Lcn12 | ENSMUSP00000141620 | ENSMUSP00000028312 | Fibronectin type III domain-containing protein 3B; May be positive regulator of adipogenesis; Belongs to the FNDC3 family. | Epididymal-specific lipocalin-12; Binds all-trans retinoic acid and may act as a retinoid carrier protein within the epididymis. May play a role in male fertility (By similarity); Belongs to the calycin superfamily. Lipocalin family. | 0.481 |
| Fndc3b | Mboat4 | ENSMUSP00000141620 | ENSMUSP00000092988 | Fibronectin type III domain-containing protein 3B; May be positive regulator of adipogenesis; Belongs to the FNDC3 family. | Ghrelin O-acyltransferase; Mediates the octanoylation of ghrelin at 'Ser-3'. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid; Belongs to the membrane-bound acyltransferase family. | 0.466 |
| Fndc3b | Mpdz | ENSMUSP00000141620 | ENSMUSP00000099894 | Fibronectin type III domain-containing protein 3B; May be positive regulator of adipogenesis; Belongs to the FNDC3 family. | Multiple PDZ domain protein; Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (By similarity). | 0.524 |
| Fndc3b | Tmco1 | ENSMUSP00000141620 | ENSMUSP00000142042 | Fibronectin type III domain-containing protein 3B; May be positive regulator of adipogenesis; Belongs to the FNDC3 family. | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store ; Belongs to the TMCO1 family. | 0.473 |
| Gmds | Fndc3b | ENSMUSP00000036696 | ENSMUSP00000141620 | GDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. | Fibronectin type III domain-containing protein 3B; May be positive regulator of adipogenesis; Belongs to the FNDC3 family. | 0.496 |
| Gmds | Tmco1 | ENSMUSP00000036696 | ENSMUSP00000142042 | GDP-mannose 4,6 dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. | Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store ; Belongs to the TMCO1 family. | 0.607 |
| Lcn12 | Fndc3b | ENSMUSP00000028312 | ENSMUSP00000141620 | Epididymal-specific lipocalin-12; Binds all-trans retinoic acid and may act as a retinoid carrier protein within the epididymis. May play a role in male fertility (By similarity); Belongs to the calycin superfamily. Lipocalin family. | Fibronectin type III domain-containing protein 3B; May be positive regulator of adipogenesis; Belongs to the FNDC3 family. | 0.481 |
| Lcn12 | Mpdz | ENSMUSP00000028312 | ENSMUSP00000099894 | Epididymal-specific lipocalin-12; Binds all-trans retinoic acid and may act as a retinoid carrier protein within the epididymis. May play a role in male fertility (By similarity); Belongs to the calycin superfamily. Lipocalin family. | Multiple PDZ domain protein; Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses (By similarity). | 0.475 |
| Mboat4 | Fndc3b | ENSMUSP00000092988 | ENSMUSP00000141620 | Ghrelin O-acyltransferase; Mediates the octanoylation of ghrelin at 'Ser-3'. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid; Belongs to the membrane-bound acyltransferase family. | Fibronectin type III domain-containing protein 3B; May be positive regulator of adipogenesis; Belongs to the FNDC3 family. | 0.466 |
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