node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cldn11 | Cldn13 | ENSMUSP00000042181 | ENSMUSP00000008987 | Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Claudin-13; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.813 |
Cldn11 | Cldn15 | ENSMUSP00000042181 | ENSMUSP00000106722 | Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Claudin-15; Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects a [...] | 0.704 |
Cldn11 | Cldn16 | ENSMUSP00000042181 | ENSMUSP00000124528 | Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Claudin-16; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors (By similarity); Belongs to [...] | 0.723 |
Cldn11 | Cldn17 | ENSMUSP00000042181 | ENSMUSP00000066427 | Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Claudin-17; Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in quantitative reabsorption of filtered anions. Does not affect water permeability; Belongs to the claudin family. | 0.757 |
Cldn11 | Cldn22 | ENSMUSP00000042181 | ENSMUSP00000041676 | Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Claudin-22; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.693 |
Cldn11 | Cldn23 | ENSMUSP00000042181 | ENSMUSP00000049725 | Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Claudin-23; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.840 |
Cldn11 | Esam | ENSMUSP00000042181 | ENSMUSP00000002011 | Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Endothelial cell-selective adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction. | 0.712 |
Cldn11 | Ocln | ENSMUSP00000042181 | ENSMUSP00000065284 | Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier; Belongs to the ELL/occludin family. | 0.960 |
Cldn11 | Tjp1 | ENSMUSP00000042181 | ENSMUSP00000099652 | Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Tight junction protein ZO-1; Tjp1, TjpP2, and Tjp3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity [...] | 0.983 |
Cldn11 | Tjp3 | ENSMUSP00000042181 | ENSMUSP00000036438 | Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Tight junction protein ZO-3; Tjp1, Tjp2, and Tjp3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton. The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PatJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (By simi [...] | 0.875 |
Cldn13 | Cldn11 | ENSMUSP00000008987 | ENSMUSP00000042181 | Claudin-13; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Claudin-11; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.813 |
Cldn13 | Cldn15 | ENSMUSP00000008987 | ENSMUSP00000106722 | Claudin-13; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Claudin-15; Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects a [...] | 0.736 |
Cldn13 | Cldn16 | ENSMUSP00000008987 | ENSMUSP00000124528 | Claudin-13; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Claudin-16; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors (By similarity); Belongs to [...] | 0.836 |
Cldn13 | Cldn17 | ENSMUSP00000008987 | ENSMUSP00000066427 | Claudin-13; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Claudin-17; Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in quantitative reabsorption of filtered anions. Does not affect water permeability; Belongs to the claudin family. | 0.727 |
Cldn13 | Cldn22 | ENSMUSP00000008987 | ENSMUSP00000041676 | Claudin-13; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Claudin-22; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.696 |
Cldn13 | Cldn23 | ENSMUSP00000008987 | ENSMUSP00000049725 | Claudin-13; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Claudin-23; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.700 |
Cldn13 | Esam | ENSMUSP00000008987 | ENSMUSP00000002011 | Claudin-13; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Endothelial cell-selective adhesion molecule; Can mediate aggregation most likely through a homophilic molecular interaction. | 0.650 |
Cldn13 | Ocln | ENSMUSP00000008987 | ENSMUSP00000065284 | Claudin-13; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier; Belongs to the ELL/occludin family. | 0.834 |
Cldn13 | Tjp1 | ENSMUSP00000008987 | ENSMUSP00000099652 | Claudin-13; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Tight junction protein ZO-1; Tjp1, TjpP2, and Tjp3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity [...] | 0.806 |
Cldn13 | Tjp3 | ENSMUSP00000008987 | ENSMUSP00000036438 | Claudin-13; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Tight junction protein ZO-3; Tjp1, Tjp2, and Tjp3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton. The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PatJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (By simi [...] | 0.767 |