STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Nlrp4fNACHT, LRR and PYD domains-containing protein 4F; May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. (937 aa)    
Predicted Functional Partners:
Ooep
Oocyte-expressed protein homolog; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions.
   
  
 0.629
Tle6
Transducin-like enhancer protein 6; As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions.
   
  
 0.618
Zbed3
Zinc finger BED domain-containing protein 3; Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression.
   
  
 0.616
Oas1h
2',5'-oligoadenylate synthetase-like 6.
   
  
 0.613
Khdc3
KH domain-containing protein 3; Required for maintenance of euploidy during cleavage-stage embryogenesis. Ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA- independent process. Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function. Capable of binding RNA.
   
  
 0.572
D5Ertd577e
DNA segment, Chr 5, ERATO Doi 577,-expressed.
   
  
 0.569
Padi6
Protein-arginine deiminase type-6; Catalyzes the deimination of arginine residues of proteins (By similarity). May be involved in cytoskeletal reorganization in the egg and early embryo.
   
  
 0.566
E330034G19Rik
RIKEN cDNA E330034G19 gene.
   
  
 0.561
Olfr976
Olfactory receptor MOR224-10.
   
  
 0.561
Cpsf4l
Cleavage and polyadenylation-specific factor 4-like.
   
  
 0.534
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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