node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ccdc186 | Eipr1 | ENSMUSP00000113457 | ENSMUSP00000152220 | Coiled-coil domain-containing protein 186. | EARP and GARP complex-interacting protein 1; Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome- associated recycling protein (EARP) complex. | 0.788 |
Ccdc186 | Rab2a | ENSMUSP00000113457 | ENSMUSP00000057664 | Coiled-coil domain-containing protein 186. | Ras-related protein Rab-2A; Required for protein transport from the endoplasmic reticulum to the Golgi complex. | 0.477 |
Ccdc186 | Rundc1 | ENSMUSP00000113457 | ENSMUSP00000042151 | Coiled-coil domain-containing protein 186. | RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity. | 0.704 |
Ccdc186 | Vps50 | ENSMUSP00000113457 | ENSMUSP00000001412 | Coiled-coil domain-containing protein 186. | Syndetin; Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN); Belongs to the syndetin family. | 0.758 |
Ccdc186 | Vps51 | ENSMUSP00000113457 | ENSMUSP00000025711 | Coiled-coil domain-containing protein 186. | Vacuolar protein sorting-associated protein 51 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome- derived carriers to the TGN. Acts as component of the EARP complex [...] | 0.731 |
Ccdc186 | Vps53 | ENSMUSP00000113457 | ENSMUSP00000061317 | Coiled-coil domain-containing protein 186. | Vacuolar protein sorting-associated protein 53 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4- positive endosomes and promotes recycling of internalized t [...] | 0.405 |
Ccdc186 | Vps54 | ENSMUSP00000113457 | ENSMUSP00000006221 | Coiled-coil domain-containing protein 186. | Vacuolar protein sorting-associated protein 54; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling. | 0.692 |
Eipr1 | Ccdc186 | ENSMUSP00000152220 | ENSMUSP00000113457 | EARP and GARP complex-interacting protein 1; Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome- associated recycling protein (EARP) complex. | Coiled-coil domain-containing protein 186. | 0.788 |
Eipr1 | Rab2a | ENSMUSP00000152220 | ENSMUSP00000057664 | EARP and GARP complex-interacting protein 1; Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome- associated recycling protein (EARP) complex. | Ras-related protein Rab-2A; Required for protein transport from the endoplasmic reticulum to the Golgi complex. | 0.505 |
Eipr1 | Rundc1 | ENSMUSP00000152220 | ENSMUSP00000042151 | EARP and GARP complex-interacting protein 1; Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome- associated recycling protein (EARP) complex. | RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity. | 0.696 |
Eipr1 | Vps50 | ENSMUSP00000152220 | ENSMUSP00000001412 | EARP and GARP complex-interacting protein 1; Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome- associated recycling protein (EARP) complex. | Syndetin; Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN); Belongs to the syndetin family. | 0.963 |
Eipr1 | Vps51 | ENSMUSP00000152220 | ENSMUSP00000025711 | EARP and GARP complex-interacting protein 1; Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome- associated recycling protein (EARP) complex. | Vacuolar protein sorting-associated protein 51 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome- derived carriers to the TGN. Acts as component of the EARP complex [...] | 0.974 |
Eipr1 | Vps53 | ENSMUSP00000152220 | ENSMUSP00000061317 | EARP and GARP complex-interacting protein 1; Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome- associated recycling protein (EARP) complex. | Vacuolar protein sorting-associated protein 53 homolog; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4- positive endosomes and promotes recycling of internalized t [...] | 0.961 |
Eipr1 | Vps54 | ENSMUSP00000152220 | ENSMUSP00000006221 | EARP and GARP complex-interacting protein 1; Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome- associated recycling protein (EARP) complex. | Vacuolar protein sorting-associated protein 54; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling. | 0.958 |
Myo18b | Rundc1 | ENSMUSP00000083810 | ENSMUSP00000042151 | Myosin XVIIIb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. | RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity. | 0.472 |
Pgap1 | Rundc1 | ENSMUSP00000095346 | ENSMUSP00000042151 | GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI- anchored proteins from the endoplasmic reticulum to the Golgi (By similarity). | RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity. | 0.501 |
Ptges3l | Rundc1 | ENSMUSP00000099391 | ENSMUSP00000042151 | Putative protein PTGES3L. | RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity. | 0.611 |
Rab2a | Ccdc186 | ENSMUSP00000057664 | ENSMUSP00000113457 | Ras-related protein Rab-2A; Required for protein transport from the endoplasmic reticulum to the Golgi complex. | Coiled-coil domain-containing protein 186. | 0.477 |
Rab2a | Eipr1 | ENSMUSP00000057664 | ENSMUSP00000152220 | Ras-related protein Rab-2A; Required for protein transport from the endoplasmic reticulum to the Golgi complex. | EARP and GARP complex-interacting protein 1; Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network. Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein. Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome- associated recycling protein (EARP) complex. | 0.505 |
Rab2a | Rundc1 | ENSMUSP00000057664 | ENSMUSP00000042151 | Ras-related protein Rab-2A; Required for protein transport from the endoplasmic reticulum to the Golgi complex. | RUN domain-containing protein 1; May play a role as p53/TP53 inhibitor and thus may have oncogenic activity. | 0.528 |