node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Eml6 | Epb41l4a | ENSMUSP00000051080 | ENSMUSP00000025234 | Echinoderm microtubule-associated protein-like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; Belongs to the WD repeat EMAP family. | Band 4.1-like protein 4A. | 0.456 |
Eml6 | Pcnx2 | ENSMUSP00000051080 | ENSMUSP00000042294 | Echinoderm microtubule-associated protein-like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; Belongs to the WD repeat EMAP family. | Pecanex-like protein 2; May play a role in tumorigenesis. | 0.416 |
Epb41l4a | Eml6 | ENSMUSP00000025234 | ENSMUSP00000051080 | Band 4.1-like protein 4A. | Echinoderm microtubule-associated protein-like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; Belongs to the WD repeat EMAP family. | 0.456 |
Epb41l4a | Pcnx2 | ENSMUSP00000025234 | ENSMUSP00000042294 | Band 4.1-like protein 4A. | Pecanex-like protein 2; May play a role in tumorigenesis. | 0.445 |
Gria4 | Pcnx2 | ENSMUSP00000027020 | ENSMUSP00000042294 | Glutamate receptor 4; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of [...] | Pecanex-like protein 2; May play a role in tumorigenesis. | 0.446 |
Lrrc34 | Pcnx2 | ENSMUSP00000029252 | ENSMUSP00000042294 | Leucine-rich repeat-containing protein 34; Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro. | Pecanex-like protein 2; May play a role in tumorigenesis. | 0.478 |
Pcnx2 | Eml6 | ENSMUSP00000042294 | ENSMUSP00000051080 | Pecanex-like protein 2; May play a role in tumorigenesis. | Echinoderm microtubule-associated protein-like 6; May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic; Belongs to the WD repeat EMAP family. | 0.416 |
Pcnx2 | Epb41l4a | ENSMUSP00000042294 | ENSMUSP00000025234 | Pecanex-like protein 2; May play a role in tumorigenesis. | Band 4.1-like protein 4A. | 0.445 |
Pcnx2 | Gria4 | ENSMUSP00000042294 | ENSMUSP00000027020 | Pecanex-like protein 2; May play a role in tumorigenesis. | Glutamate receptor 4; Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of [...] | 0.446 |
Pcnx2 | Lrrc34 | ENSMUSP00000042294 | ENSMUSP00000029252 | Pecanex-like protein 2; May play a role in tumorigenesis. | Leucine-rich repeat-containing protein 34; Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro. | 0.478 |
Pcnx2 | Plpp4 | ENSMUSP00000042294 | ENSMUSP00000091557 | Pecanex-like protein 2; May play a role in tumorigenesis. | Phospholipid phosphatase 4; Magnesium-independent phospholipid phosphatase with broad substrate specificity. Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate. Phospholipid phosphatases are involved in both the synthesis of lipids and the degradation or generation of lipid-signaling molecules like diacylglycerol. | 0.428 |
Pcnx2 | Ppfia2 | ENSMUSP00000042294 | ENSMUSP00000151545 | Pecanex-like protein 2; May play a role in tumorigenesis. | Liprin-alpha-2; Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines; Belongs to the liprin family. Liprin-alpha subfamily. | 0.453 |
Pcnx2 | Taf1b | ENSMUSP00000042294 | ENSMUSP00000075339 | Pecanex-like protein 2; May play a role in tumorigenesis. | TATA box-binding protein-associated factor RNA polymerase I subunit B; Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3. | 0.541 |
Plpp4 | Pcnx2 | ENSMUSP00000091557 | ENSMUSP00000042294 | Phospholipid phosphatase 4; Magnesium-independent phospholipid phosphatase with broad substrate specificity. Preferentially catalyzes the conversion of diacylglycerol pyrophosphate into phosphatidate but can also act on phosphatidate and lysophosphatidate. Phospholipid phosphatases are involved in both the synthesis of lipids and the degradation or generation of lipid-signaling molecules like diacylglycerol. | Pecanex-like protein 2; May play a role in tumorigenesis. | 0.428 |
Ppfia2 | Pcnx2 | ENSMUSP00000151545 | ENSMUSP00000042294 | Liprin-alpha-2; Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. In neuronal cells, is a scaffolding protein in the dendritic spines which acts as immobile postsynaptic post able to recruit KIF1A-driven dense core vesicles to dendritic spines; Belongs to the liprin family. Liprin-alpha subfamily. | Pecanex-like protein 2; May play a role in tumorigenesis. | 0.453 |
Taf1b | Pcnx2 | ENSMUSP00000075339 | ENSMUSP00000042294 | TATA box-binding protein-associated factor RNA polymerase I subunit B; Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3. | Pecanex-like protein 2; May play a role in tumorigenesis. | 0.541 |