STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Igflr1IGF-like family receptor 1; Probable cell membrane receptor for the IGF-like family protein IGFL. (345 aa)    
Predicted Functional Partners:
Igfl3
Insulin growth factor-like family member; Probable ligand of the IGFLR1 cell membrane receptor.
    
 
 0.821
Nrde2
Nuclear exosome regulator NRDE2; Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation. Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation. Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome. By preventing the degradation of RNAs in the nucleus, [...]
   
 
 0.637
Cyyr1
Cysteine and tyrosine-rich protein 1.
      
 0.595
Il18bp
Interleukin-18-binding protein; Binds to IL-18 and inhibits its activity. Functions as an inhibitor of the early TH1 cytokine response (By similarity).
      
 0.504
Leo1
RNA polymerase-associated protein LEO1; Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser- 5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox [...]
    
 
 0.495
Hba-x
Hemoglobin subunit zeta; The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin; Belongs to the globin family.
    
 
 0.465
Ccdc160
Coiled-coil domain-containing protein 160; Belongs to the CCDC160 family.
   
 
 0.462
1600002K03Rik
Protein FAM174C.
   
  
 0.460
Rbm42
RNA-binding protein 42; Binds (via the RRM domain) to the 3'-untranslated region (UTR) of CDKN1A mRNA.
      
 0.457
Prss58
Putative inactive serine protease 58; Belongs to the peptidase S1 family.
    
 
 0.440
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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