node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Akt3 | Edn3 | ENSMUSP00000106789 | ENSMUSP00000029030 | RAC-gamma serine/threonine-protein kinase; AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial fo [...] | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | 0.539 |
Akt3 | Fras1 | ENSMUSP00000106789 | ENSMUSP00000043250 | RAC-gamma serine/threonine-protein kinase; AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial fo [...] | Extracellular matrix protein FRAS1; Belongs to the FRAS1 family. | 0.537 |
Akt3 | Ptprk | ENSMUSP00000106789 | ENSMUSP00000126279 | RAC-gamma serine/threonine-protein kinase; AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial fo [...] | Receptor-type tyrosine-protein phosphatase kappa; Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa; Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. | 0.576 |
Edn3 | Akt3 | ENSMUSP00000029030 | ENSMUSP00000106789 | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | RAC-gamma serine/threonine-protein kinase; AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial fo [...] | 0.539 |
Edn3 | Fras1 | ENSMUSP00000029030 | ENSMUSP00000043250 | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | Extracellular matrix protein FRAS1; Belongs to the FRAS1 family. | 0.552 |
Edn3 | Ptprk | ENSMUSP00000029030 | ENSMUSP00000126279 | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | Receptor-type tyrosine-protein phosphatase kappa; Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa; Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. | 0.554 |
Fam163a | Fras1 | ENSMUSP00000015628 | ENSMUSP00000043250 | Protein FAM163A. | Extracellular matrix protein FRAS1; Belongs to the FRAS1 family. | 0.580 |
Fras1 | Akt3 | ENSMUSP00000043250 | ENSMUSP00000106789 | Extracellular matrix protein FRAS1; Belongs to the FRAS1 family. | RAC-gamma serine/threonine-protein kinase; AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial fo [...] | 0.537 |
Fras1 | Edn3 | ENSMUSP00000043250 | ENSMUSP00000029030 | Extracellular matrix protein FRAS1; Belongs to the FRAS1 family. | Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides; Belongs to the endothelin/sarafotoxin family. | 0.552 |
Fras1 | Fam163a | ENSMUSP00000043250 | ENSMUSP00000015628 | Extracellular matrix protein FRAS1; Belongs to the FRAS1 family. | Protein FAM163A. | 0.580 |
Fras1 | Frem1 | ENSMUSP00000043250 | ENSMUSP00000071627 | Extracellular matrix protein FRAS1; Belongs to the FRAS1 family. | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family. | 0.987 |
Fras1 | Frem2 | ENSMUSP00000043250 | ENSMUSP00000088670 | Extracellular matrix protein FRAS1; Belongs to the FRAS1 family. | FRAS1-related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia (By similarity). Required for epidermal adhesion. Involved in the development of eyelids and the anterior segment of the eyeballs ; Belongs to the FRAS1 family. | 0.984 |
Fras1 | Grip1 | ENSMUSP00000043250 | ENSMUSP00000123234 | Extracellular matrix protein FRAS1; Belongs to the FRAS1 family. | Glutamate receptor-interacting protein 1; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (By similarity). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). | 0.675 |
Fras1 | Hmcn1 | ENSMUSP00000043250 | ENSMUSP00000074340 | Extracellular matrix protein FRAS1; Belongs to the FRAS1 family. | Hemicentin-1; Promotes cleavage furrow maturation during cytokinesis in preimplantation embryos. May play a role in the architecture of adhesive and flexible epithelial cell junctions. May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration. | 0.688 |
Fras1 | Itga8 | ENSMUSP00000043250 | ENSMUSP00000028106 | Extracellular matrix protein FRAS1; Belongs to the FRAS1 family. | Integrin alpha-8 heavy chain; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. | 0.941 |
Fras1 | Itgb1 | ENSMUSP00000043250 | ENSMUSP00000087457 | Extracellular matrix protein FRAS1; Belongs to the FRAS1 family. | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] | 0.908 |
Fras1 | Ptprk | ENSMUSP00000043250 | ENSMUSP00000126279 | Extracellular matrix protein FRAS1; Belongs to the FRAS1 family. | Receptor-type tyrosine-protein phosphatase kappa; Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa; Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. | 0.579 |
Frem1 | Fras1 | ENSMUSP00000071627 | ENSMUSP00000043250 | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family. | Extracellular matrix protein FRAS1; Belongs to the FRAS1 family. | 0.987 |
Frem1 | Frem2 | ENSMUSP00000071627 | ENSMUSP00000088670 | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family. | FRAS1-related extracellular matrix protein 2; Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia (By similarity). Required for epidermal adhesion. Involved in the development of eyelids and the anterior segment of the eyeballs ; Belongs to the FRAS1 family. | 0.990 |
Frem1 | Grip1 | ENSMUSP00000071627 | ENSMUSP00000123234 | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family. | Glutamate receptor-interacting protein 1; May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons (By similarity). Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity). | 0.525 |