STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cmtm8CKLF-like MARVEL transmembrane domain-containing protein 8. (173 aa)    
Predicted Functional Partners:
Cmtm7
CKLF-like MARVEL transmembrane domain-containing protein 7; Belongs to the chemokine-like factor family.
      
 0.851
Cmtm6
CKLF-like MARVEL transmembrane domain-containing protein 6; Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately trigge [...]
   
  
 0.809
Cklf
Chemokine-like factor; May play an important role in inflammation and regeneration of skeletal muscle.
      
 0.788
Cmtm3
CKLF-like MARVEL transmembrane domain-containing protein 3.
   
  
 0.778
Cmtm5
CKLF-like MARVEL transmembrane domain-containing protein 5; Belongs to the chemokine-like factor family.
      
 0.759
Cmtm1
CKLF-like MARVEL transmembrane domain-containing 1.
      
 0.742
Sec14l4
SEC14-like protein 4; Probable hydrophobic ligand-binding protein; may play a role in the transport of hydrophobic ligands like tocopherol, squalene and phospholipids.
   
   0.566
Mmrn2
Multimerin-2; Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA.
   
    0.537
Tmppe
Transmembrane protein with metallophosphoesterase domain.
      
 0.514
Myadml2
Myeloid-associated differentiation marker-like protein 2; Belongs to the MAL family.
      
 0.477
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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