node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cacna2d2 | Cyb561d2 | ENSMUSP00000132512 | ENSMUSP00000044093 | Voltage-dependent calcium channel subunit alpha-2/delta-2; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q- type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). | Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction. | 0.663 |
Cacna2d2 | Nprl2 | ENSMUSP00000132512 | ENSMUSP00000010201 | Voltage-dependent calcium channel subunit alpha-2/delta-2; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q- type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). | GATOR complex protein NPRL2; As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway; Belongs to the NPR2 family. | 0.458 |
Cacna2d2 | Zmynd10 | ENSMUSP00000132512 | ENSMUSP00000010188 | Voltage-dependent calcium channel subunit alpha-2/delta-2; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q- type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). | Zinc finger MYND domain-containing protein 10; Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins (By similarity); Belongs to the ZMYND10 family. | 0.598 |
Cyb561a3 | Cyb561d2 | ENSMUSP00000158186 | ENSMUSP00000044093 | Cytochrome b ascorbate-dependent protein 3; Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Probably uses ascorbate as electron donor. | Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction. | 0.578 |
Cyb561d2 | Cacna2d2 | ENSMUSP00000044093 | ENSMUSP00000132512 | Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction. | Voltage-dependent calcium channel subunit alpha-2/delta-2; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q- type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). | 0.663 |
Cyb561d2 | Cyb561a3 | ENSMUSP00000044093 | ENSMUSP00000158186 | Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction. | Cytochrome b ascorbate-dependent protein 3; Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Probably uses ascorbate as electron donor. | 0.578 |
Cyb561d2 | Hyal1 | ENSMUSP00000044093 | ENSMUSP00000010195 | Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction. | Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. | 0.530 |
Cyb561d2 | Hyal2 | ENSMUSP00000044093 | ENSMUSP00000141280 | Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction. | Hyaluronidase-2; Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R (By similarity). | 0.665 |
Cyb561d2 | Ints1 | ENSMUSP00000044093 | ENSMUSP00000143789 | Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction. | Integrator complex subunit 1; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. | 0.529 |
Cyb561d2 | Ints3 | ENSMUSP00000044093 | ENSMUSP00000029542 | Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction. | Integrator complex subunit 3; Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. | 0.531 |
Cyb561d2 | Ints5 | ENSMUSP00000044093 | ENSMUSP00000093968 | Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction. | Integrator complex subunit 5; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. | 0.534 |
Cyb561d2 | Nprl2 | ENSMUSP00000044093 | ENSMUSP00000010201 | Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction. | GATOR complex protein NPRL2; As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway; Belongs to the NPR2 family. | 0.723 |
Cyb561d2 | Rassf1 | ENSMUSP00000044093 | ENSMUSP00000091301 | Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction. | Ras association domain-containing protein 1; Potential tumor suppressor. Required for death receptor- dependent apoptosis. Mediates activation of Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by [...] | 0.554 |
Cyb561d2 | Zmynd10 | ENSMUSP00000044093 | ENSMUSP00000010188 | Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction. | Zinc finger MYND domain-containing protein 10; Plays a role in axonemal structure organization and motility. Involved in axonemal pre-assembly of inner and outer dynein arms (IDA and ODA, respectively) for proper axoneme building for cilia motility. May act by indirectly regulating transcription of dynein proteins (By similarity); Belongs to the ZMYND10 family. | 0.620 |
Hyal1 | Cyb561d2 | ENSMUSP00000010195 | ENSMUSP00000044093 | Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. | Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction. | 0.530 |
Hyal2 | Cyb561d2 | ENSMUSP00000141280 | ENSMUSP00000044093 | Hyaluronidase-2; Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R (By similarity). | Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction. | 0.665 |
Hyal2 | Nprl2 | ENSMUSP00000141280 | ENSMUSP00000010201 | Hyaluronidase-2; Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R (By similarity). | GATOR complex protein NPRL2; As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway; Belongs to the NPR2 family. | 0.475 |
Ints1 | Cyb561d2 | ENSMUSP00000143789 | ENSMUSP00000044093 | Integrator complex subunit 1; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. | Cytochrome b561 domain-containing protein 2; Two-heme-containing cytochrome that catalyzes ascorbate- dependent trans-membrane ferric-chelate reduction. | 0.529 |
Ints1 | Ints3 | ENSMUSP00000143789 | ENSMUSP00000029542 | Integrator complex subunit 1; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. | Integrator complex subunit 3; Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. | 0.999 |
Ints1 | Ints5 | ENSMUSP00000143789 | ENSMUSP00000093968 | Integrator complex subunit 1; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. | Integrator complex subunit 5; Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. | 0.999 |