node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Mrpl11 | Tbc1d2b | ENSMUSP00000025836 | ENSMUSP00000045413 | 39S ribosomal protein L11, mitochondrial; Belongs to the universal ribosomal protein uL11 family. | TBC1 domain family member 2B; May act as a GTPase-activating protein. | 0.451 |
Nrde2 | Tbc1d2b | ENSMUSP00000021596 | ENSMUSP00000045413 | Nuclear exosome regulator NRDE2; Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation. Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation. Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome. By preventing the degradation of RNAs in the nucleus, [...] | TBC1 domain family member 2B; May act as a GTPase-activating protein. | 0.455 |
Rab31 | Tbc1d2b | ENSMUSP00000068195 | ENSMUSP00000045413 | Ras-related protein Rab-31; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Pl [...] | TBC1 domain family member 2B; May act as a GTPase-activating protein. | 0.600 |
Rab35 | Tbc1d13 | ENSMUSP00000031492 | ENSMUSP00000048426 | Ras-related protein Rab-35; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required f [...] | TBC1 domain family member 13; Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes. | 0.695 |
Rab35 | Tbc1d2b | ENSMUSP00000031492 | ENSMUSP00000045413 | Ras-related protein Rab-35; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required f [...] | TBC1 domain family member 2B; May act as a GTPase-activating protein. | 0.496 |
Tbc1d13 | Rab35 | ENSMUSP00000048426 | ENSMUSP00000031492 | TBC1 domain family member 13; Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes. | Ras-related protein Rab-35; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required f [...] | 0.695 |
Tbc1d13 | Tbc1d19 | ENSMUSP00000048426 | ENSMUSP00000040585 | TBC1 domain family member 13; Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes. | TBC1 domain family, member 19. | 0.668 |
Tbc1d13 | Tbc1d21 | ENSMUSP00000048426 | ENSMUSP00000037525 | TBC1 domain family member 13; Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes. | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity. | 0.710 |
Tbc1d13 | Tbc1d2b | ENSMUSP00000048426 | ENSMUSP00000045413 | TBC1 domain family member 13; Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes. | TBC1 domain family member 2B; May act as a GTPase-activating protein. | 0.484 |
Tbc1d19 | Tbc1d13 | ENSMUSP00000040585 | ENSMUSP00000048426 | TBC1 domain family, member 19. | TBC1 domain family member 13; Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes. | 0.668 |
Tbc1d19 | Tbc1d21 | ENSMUSP00000040585 | ENSMUSP00000037525 | TBC1 domain family, member 19. | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity. | 0.725 |
Tbc1d19 | Tbc1d2b | ENSMUSP00000040585 | ENSMUSP00000045413 | TBC1 domain family, member 19. | TBC1 domain family member 2B; May act as a GTPase-activating protein. | 0.520 |
Tbc1d19 | Tbc1d5 | ENSMUSP00000040585 | ENSMUSP00000024717 | TBC1 domain family, member 19. | TBC1 domain family member 5; May act as a GTPase-activating protein for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity. Required for retrograde transport of cargo proteins from endosomes to the trans- Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy. May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming ves [...] | 0.476 |
Tbc1d21 | Tbc1d13 | ENSMUSP00000037525 | ENSMUSP00000048426 | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity. | TBC1 domain family member 13; Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes. | 0.710 |
Tbc1d21 | Tbc1d19 | ENSMUSP00000037525 | ENSMUSP00000040585 | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity. | TBC1 domain family, member 19. | 0.725 |
Tbc1d21 | Tbc1d2b | ENSMUSP00000037525 | ENSMUSP00000045413 | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity. | TBC1 domain family member 2B; May act as a GTPase-activating protein. | 0.485 |
Tbc1d21 | Tbc1d5 | ENSMUSP00000037525 | ENSMUSP00000024717 | TBC1 domain family member 21; May act as a GTPase-activating protein for Rab family protein(s). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity. | TBC1 domain family member 5; May act as a GTPase-activating protein for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity. Required for retrograde transport of cargo proteins from endosomes to the trans- Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy. May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming ves [...] | 0.488 |
Tbc1d25 | Tbc1d2b | ENSMUSP00000047838 | ENSMUSP00000045413 | TBC1 domain family member 25; Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes. | TBC1 domain family member 2B; May act as a GTPase-activating protein. | 0.531 |
Tbc1d25 | Tbc1d5 | ENSMUSP00000047838 | ENSMUSP00000024717 | TBC1 domain family member 25; Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes. | TBC1 domain family member 5; May act as a GTPase-activating protein for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity. Required for retrograde transport of cargo proteins from endosomes to the trans- Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy. May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming ves [...] | 0.681 |
Tbc1d2b | Mrpl11 | ENSMUSP00000045413 | ENSMUSP00000025836 | TBC1 domain family member 2B; May act as a GTPase-activating protein. | 39S ribosomal protein L11, mitochondrial; Belongs to the universal ribosomal protein uL11 family. | 0.451 |