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H2-Aa protein (mouse) - STRING interaction network
"H2-Aa" - Histocompatibility 2, class II antigen A, alpha in Mus musculus
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
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[Homology]
Score
H2-AaHistocompatibility 2, class II antigen A, alpha (256 aa)    
Predicted Functional Partners:
H2-Ab1
Histocompatibility 2, class II antigen A, beta 1; Belongs to the MHC class II family (265 aa)
     
0.999
Cd74
H-2 class II histocompatibility antigen gamma chain; Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place (279 aa)
     
  0.998
H2-Eb1
Histocompatibility 2, class II antigen E beta; Belongs to the MHC class II family (264 aa)
     
0.986
H2-DMb1
Class II histocompatibility antigen, M beta 1 chain; Plays a critical role in catalyzing the release of class II HLA-associated invariant chain-derived peptides (CLIP) from newly synthesized class II HLA molecules and freeing the peptide binding site for acquisition of antigenic peptides; Belongs to the MHC class II family (261 aa)
     
0.982
H2-DMb2
Histocompatibility 2, class II, locus Mb2; Belongs to the MHC class II family (261 aa)
     
0.980
H2-DMa
Class II histocompatibility antigen, M alpha chain; Plays a critical role in catalyzing the release of class II HLA-associated invariant chain-derived peptides (CLIP) from newly synthesized class II HLA molecules and freeing the peptide binding site for acquisition of antigenic peptides (261 aa)
     
0.977
Cd4
T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule-peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (457 aa)
     
  0.954
H2-Ob
Histocompatibility 2, O region beta locus; Belongs to the MHC class II family (271 aa)
     
0.952
Ctss
Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N; Belongs to the peptidase C1 family (341 aa)
     
 
  0.943
H2-Eb2
Histocompatibility 2, class II antigen E beta2; Belongs to the MHC class II family (287 aa)
     
0.937
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus muscaris, Mus musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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