node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Asprv1 | Blmh | ENSMUSP00000046121 | ENSMUSP00000021197 | Retroviral-like aspartic protease 1. | Bleomycin hydrolase; The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity; Belongs to the peptidase C1 family. | 0.604 |
Asprv1 | Calm4 | ENSMUSP00000046121 | ENSMUSP00000041636 | Retroviral-like aspartic protease 1. | Calmodulin-4; Implicated in the early stage of ectopic ossification. | 0.563 |
Asprv1 | Casp14 | ENSMUSP00000046121 | ENSMUSP00000005488 | Retroviral-like aspartic protease 1. | Caspase-14 subunit p20, intermediate form; Non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin. In vitro is equally active on the synthetic caspase substrates WEHD-ACF and IETD-AFC. Involved in processing of prosaposin in the epidermis. May be involved in retinal pigment epithelium cell barrier function (By similarity). Belongs to the peptidase C14A family. | 0.595 |
Asprv1 | Cdsn | ENSMUSP00000046121 | ENSMUSP00000048596 | Retroviral-like aspartic protease 1. | Corneodesmosin; Important for the epidermal barrier integrity. | 0.577 |
Asprv1 | Dsc1 | ENSMUSP00000046121 | ENSMUSP00000042303 | Retroviral-like aspartic protease 1. | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | 0.582 |
Asprv1 | Flg | ENSMUSP00000046121 | ENSMUSP00000142003 | Retroviral-like aspartic protease 1. | Filaggrin. | 0.621 |
Asprv1 | Krtdap | ENSMUSP00000046121 | ENSMUSP00000096159 | Retroviral-like aspartic protease 1. | Keratinocyte differentiation-associated protein; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis (By similarity). | 0.533 |
Asprv1 | Nipal4 | ENSMUSP00000046121 | ENSMUSP00000020679 | Retroviral-like aspartic protease 1. | Magnesium transporter NIPA4; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway (By similarity); Belongs to the NIPA family. | 0.529 |
Asprv1 | Olfr1055 | ENSMUSP00000046121 | ENSMUSP00000149219 | Retroviral-like aspartic protease 1. | Olfactory receptor. | 0.606 |
Asprv1 | Stfa3 | ENSMUSP00000046121 | ENSMUSP00000067445 | Retroviral-like aspartic protease 1. | Stefin-3; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family. | 0.584 |
Blmh | Asprv1 | ENSMUSP00000021197 | ENSMUSP00000046121 | Bleomycin hydrolase; The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity; Belongs to the peptidase C1 family. | Retroviral-like aspartic protease 1. | 0.604 |
Blmh | Casp14 | ENSMUSP00000021197 | ENSMUSP00000005488 | Bleomycin hydrolase; The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity; Belongs to the peptidase C1 family. | Caspase-14 subunit p20, intermediate form; Non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin. In vitro is equally active on the synthetic caspase substrates WEHD-ACF and IETD-AFC. Involved in processing of prosaposin in the epidermis. May be involved in retinal pigment epithelium cell barrier function (By similarity). Belongs to the peptidase C14A family. | 0.811 |
Blmh | Flg | ENSMUSP00000021197 | ENSMUSP00000142003 | Bleomycin hydrolase; The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity; Belongs to the peptidase C1 family. | Filaggrin. | 0.578 |
Calm4 | Asprv1 | ENSMUSP00000041636 | ENSMUSP00000046121 | Calmodulin-4; Implicated in the early stage of ectopic ossification. | Retroviral-like aspartic protease 1. | 0.563 |
Calm4 | Dsc1 | ENSMUSP00000041636 | ENSMUSP00000042303 | Calmodulin-4; Implicated in the early stage of ectopic ossification. | Desmocollin-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. | 0.559 |
Calm4 | Flg | ENSMUSP00000041636 | ENSMUSP00000142003 | Calmodulin-4; Implicated in the early stage of ectopic ossification. | Filaggrin. | 0.636 |
Calm4 | Krtdap | ENSMUSP00000041636 | ENSMUSP00000096159 | Calmodulin-4; Implicated in the early stage of ectopic ossification. | Keratinocyte differentiation-associated protein; May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin morphogenesis (By similarity). | 0.771 |
Casp14 | Asprv1 | ENSMUSP00000005488 | ENSMUSP00000046121 | Caspase-14 subunit p20, intermediate form; Non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin. In vitro is equally active on the synthetic caspase substrates WEHD-ACF and IETD-AFC. Involved in processing of prosaposin in the epidermis. May be involved in retinal pigment epithelium cell barrier function (By similarity). Belongs to the peptidase C14A family. | Retroviral-like aspartic protease 1. | 0.595 |
Casp14 | Blmh | ENSMUSP00000005488 | ENSMUSP00000021197 | Caspase-14 subunit p20, intermediate form; Non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin. In vitro is equally active on the synthetic caspase substrates WEHD-ACF and IETD-AFC. Involved in processing of prosaposin in the epidermis. May be involved in retinal pigment epithelium cell barrier function (By similarity). Belongs to the peptidase C14A family. | Bleomycin hydrolase; The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B- aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity; Belongs to the peptidase C1 family. | 0.811 |
Casp14 | Cdsn | ENSMUSP00000005488 | ENSMUSP00000048596 | Caspase-14 subunit p20, intermediate form; Non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin. In vitro is equally active on the synthetic caspase substrates WEHD-ACF and IETD-AFC. Involved in processing of prosaposin in the epidermis. May be involved in retinal pigment epithelium cell barrier function (By similarity). Belongs to the peptidase C14A family. | Corneodesmosin; Important for the epidermal barrier integrity. | 0.571 |