node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Gclc | Gclm | ENSMUSP00000034905 | ENSMUSP00000029769 | Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family. | Glutamate--cysteine ligase regulatory subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | 0.999 |
Gclc | Gsr | ENSMUSP00000034905 | ENSMUSP00000033992 | Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family. | Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol. | 0.900 |
Gclc | Nqo1 | ENSMUSP00000034905 | ENSMUSP00000003947 | Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family. | NAD(P)H dehydrogenase [quinone] 1; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. | 0.910 |
Gclc | Prdx1 | ENSMUSP00000034905 | ENSMUSP00000114159 | Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family. | Peroxiredoxin-1; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron diffe [...] | 0.704 |
Gclc | Prdx2 | ENSMUSP00000034905 | ENSMUSP00000105356 | Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family. | Peroxiredoxin-2; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). | 0.638 |
Gclc | Prdx3 | ENSMUSP00000034905 | ENSMUSP00000025961 | Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family. | Thioredoxin-dependent peroxide reductase, mitochondrial; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. | 0.463 |
Gclc | Srxn1 | ENSMUSP00000034905 | ENSMUSP00000046196 | Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family. | Sulfiredoxin-1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase. Belongs to the sulfiredoxin family. | 0.780 |
Gclc | Txn1 | ENSMUSP00000034905 | ENSMUSP00000030051 | Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family. | Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] | 0.775 |
Gclc | Txnrd1 | ENSMUSP00000034905 | ENSMUSP00000152046 | Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family. | Thioredoxin reductase 1, cytoplasmic; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.833 |
Gclm | Gclc | ENSMUSP00000029769 | ENSMUSP00000034905 | Glutamate--cysteine ligase regulatory subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family. | 0.999 |
Gclm | Gsr | ENSMUSP00000029769 | ENSMUSP00000033992 | Glutamate--cysteine ligase regulatory subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol. | 0.813 |
Gclm | Nqo1 | ENSMUSP00000029769 | ENSMUSP00000003947 | Glutamate--cysteine ligase regulatory subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | NAD(P)H dehydrogenase [quinone] 1; The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. | 0.913 |
Gclm | Prdx1 | ENSMUSP00000029769 | ENSMUSP00000114159 | Glutamate--cysteine ligase regulatory subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | Peroxiredoxin-1; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron diffe [...] | 0.673 |
Gclm | Prdx2 | ENSMUSP00000029769 | ENSMUSP00000105356 | Glutamate--cysteine ligase regulatory subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | Peroxiredoxin-2; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). | 0.587 |
Gclm | Prdx3 | ENSMUSP00000029769 | ENSMUSP00000025961 | Glutamate--cysteine ligase regulatory subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | Thioredoxin-dependent peroxide reductase, mitochondrial; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. | 0.495 |
Gclm | Srxn1 | ENSMUSP00000029769 | ENSMUSP00000046196 | Glutamate--cysteine ligase regulatory subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | Sulfiredoxin-1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase. Belongs to the sulfiredoxin family. | 0.826 |
Gclm | Txn1 | ENSMUSP00000029769 | ENSMUSP00000030051 | Glutamate--cysteine ligase regulatory subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] | 0.697 |
Gclm | Txnrd1 | ENSMUSP00000029769 | ENSMUSP00000152046 | Glutamate--cysteine ligase regulatory subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | Thioredoxin reductase 1, cytoplasmic; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.795 |
Gsr | Gclc | ENSMUSP00000033992 | ENSMUSP00000034905 | Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol. | Glutamate--cysteine ligase catalytic subunit; Belongs to the glutamate--cysteine ligase type 3 family. | 0.900 |
Gsr | Gclm | ENSMUSP00000033992 | ENSMUSP00000029769 | Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol. | Glutamate--cysteine ligase regulatory subunit; Belongs to the aldo/keto reductase family. Glutamate-- cysteine ligase light chain subfamily. | 0.813 |