| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Adam22 | Adam23 | ENSMUSP00000086139 | ENSMUSP00000084633 | Disintegrin and metalloproteinase domain-containing protein 22; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation (By similarity). Neuronal receptor for LGI1. | Disintegrin and metalloproteinase domain-containing protein 23; May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein (By similarity). | 0.916 |
| Adam22 | Dlg2 | ENSMUSP00000086139 | ENSMUSP00000102814 | Disintegrin and metalloproteinase domain-containing protein 22; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation (By similarity). Neuronal receptor for LGI1. | Disks large homolog 2; Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses. | 0.955 |
| Adam22 | Lgi3 | ENSMUSP00000086139 | ENSMUSP00000046705 | Disintegrin and metalloproteinase domain-containing protein 22; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation (By similarity). Neuronal receptor for LGI1. | Leucine-rich repeat LGI family member 3; May participate in the regulation of neuronal exocytosis. | 0.936 |
| Adam22 | Stx1a | ENSMUSP00000086139 | ENSMUSP00000005509 | Disintegrin and metalloproteinase domain-containing protein 22; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation (By similarity). Neuronal receptor for LGI1. | Syntaxin-1A; Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final [...] | 0.496 |
| Adam22 | Stx1b | ENSMUSP00000086139 | ENSMUSP00000101874 | Disintegrin and metalloproteinase domain-containing protein 22; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation (By similarity). Neuronal receptor for LGI1. | Syntaxin-1B; Potentially involved in docking of synaptic vesicles at presynaptic active zones (By similarity). May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm; Belongs to the syntaxin family. | 0.513 |
| Adam23 | Adam22 | ENSMUSP00000084633 | ENSMUSP00000086139 | Disintegrin and metalloproteinase domain-containing protein 23; May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein (By similarity). | Disintegrin and metalloproteinase domain-containing protein 22; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation (By similarity). Neuronal receptor for LGI1. | 0.916 |
| Adam23 | Dlg2 | ENSMUSP00000084633 | ENSMUSP00000102814 | Disintegrin and metalloproteinase domain-containing protein 23; May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein (By similarity). | Disks large homolog 2; Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses. | 0.532 |
| Adam23 | Lgi3 | ENSMUSP00000084633 | ENSMUSP00000046705 | Disintegrin and metalloproteinase domain-containing protein 23; May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein (By similarity). | Leucine-rich repeat LGI family member 3; May participate in the regulation of neuronal exocytosis. | 0.946 |
| Adam23 | Stx1a | ENSMUSP00000084633 | ENSMUSP00000005509 | Disintegrin and metalloproteinase domain-containing protein 23; May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein (By similarity). | Syntaxin-1A; Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final [...] | 0.433 |
| Adam23 | Stx1b | ENSMUSP00000084633 | ENSMUSP00000101874 | Disintegrin and metalloproteinase domain-containing protein 23; May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein (By similarity). | Syntaxin-1B; Potentially involved in docking of synaptic vesicles at presynaptic active zones (By similarity). May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm; Belongs to the syntaxin family. | 0.443 |
| Adgrf5 | Lgi3 | ENSMUSP00000109229 | ENSMUSP00000046705 | Adhesion G protein-coupled receptor F5; Receptor that plays a critical role in lung surfactant homeostasis. May play a role in controlling adipocyte function. | Leucine-rich repeat LGI family member 3; May participate in the regulation of neuronal exocytosis. | 0.532 |
| Adgrf5 | Rasgef1a | ENSMUSP00000109229 | ENSMUSP00000145077 | Adhesion G protein-coupled receptor F5; Receptor that plays a critical role in lung surfactant homeostasis. May play a role in controlling adipocyte function. | RasGEF domain family, member 1A. | 0.436 |
| Dlg2 | Adam22 | ENSMUSP00000102814 | ENSMUSP00000086139 | Disks large homolog 2; Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses. | Disintegrin and metalloproteinase domain-containing protein 22; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation (By similarity). Neuronal receptor for LGI1. | 0.955 |
| Dlg2 | Adam23 | ENSMUSP00000102814 | ENSMUSP00000084633 | Disks large homolog 2; Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses. | Disintegrin and metalloproteinase domain-containing protein 23; May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein (By similarity). | 0.532 |
| Dlg2 | Lgi3 | ENSMUSP00000102814 | ENSMUSP00000046705 | Disks large homolog 2; Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses. | Leucine-rich repeat LGI family member 3; May participate in the regulation of neuronal exocytosis. | 0.463 |
| Got1l1 | Lgi3 | ENSMUSP00000041337 | ENSMUSP00000046705 | Putative aspartate aminotransferase, cytoplasmic 2; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | Leucine-rich repeat LGI family member 3; May participate in the regulation of neuronal exocytosis. | 0.584 |
| Got1l1 | Sorbs3 | ENSMUSP00000041337 | ENSMUSP00000022682 | Putative aspartate aminotransferase, cytoplasmic 2; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. | Vinexin; Promotes up-regulation of actin stress fiber formation. | 0.554 |
| Lgi3 | Adam22 | ENSMUSP00000046705 | ENSMUSP00000086139 | Leucine-rich repeat LGI family member 3; May participate in the regulation of neuronal exocytosis. | Disintegrin and metalloproteinase domain-containing protein 22; Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation (By similarity). Neuronal receptor for LGI1. | 0.936 |
| Lgi3 | Adam23 | ENSMUSP00000046705 | ENSMUSP00000084633 | Leucine-rich repeat LGI family member 3; May participate in the regulation of neuronal exocytosis. | Disintegrin and metalloproteinase domain-containing protein 23; May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein (By similarity). | 0.946 |
| Lgi3 | Adgrf5 | ENSMUSP00000046705 | ENSMUSP00000109229 | Leucine-rich repeat LGI family member 3; May participate in the regulation of neuronal exocytosis. | Adhesion G protein-coupled receptor F5; Receptor that plays a critical role in lung surfactant homeostasis. May play a role in controlling adipocyte function. | 0.532 |
STRING v12.5 is now available!
