Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Ak2 | Dusp26 | ENSMUSP00000030583 | ENSMUSP00000046794 | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. | 0.643 |
| Def8 | Dusp26 | ENSMUSP00000104460 | ENSMUSP00000046794 | Differentially expressed in FDCP 8; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. | 0.410 |
| Def8 | Mthfsd | ENSMUSP00000104460 | ENSMUSP00000112116 | Differentially expressed in FDCP 8; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. | Methenyltetrahydrofolate synthase domain-containing protein. | 0.646 |
| Dusp26 | Ak2 | ENSMUSP00000046794 | ENSMUSP00000030583 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. | 0.643 |
| Dusp26 | Def8 | ENSMUSP00000046794 | ENSMUSP00000104460 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. | Differentially expressed in FDCP 8; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. | 0.410 |
| Dusp26 | Hdhd5 | ENSMUSP00000046794 | ENSMUSP00000074775 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. | Haloacid dehalogenase-like hydrolase domain-containing 5; Belongs to the HAD-like hydrolase superfamily. | 0.643 |
| Dusp26 | Hipk2 | ENSMUSP00000046794 | ENSMUSP00000124133 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. | Homeodomain-interacting protein kinase 2; Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect [...] | 0.574 |
| Dusp26 | Mthfsd | ENSMUSP00000046794 | ENSMUSP00000112116 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. | Methenyltetrahydrofolate synthase domain-containing protein. | 0.445 |
| Dusp26 | Npas4 | ENSMUSP00000046794 | ENSMUSP00000062992 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. | Neuronal PAS domain-containing protein 4; Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hyppocampus. Plays a key role in the structural and functional plasticity of neurons. Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activ [...] | 0.415 |
| Dusp26 | Ptpn3 | ENSMUSP00000046794 | ENSMUSP00000075063 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. | Tyrosine-protein phosphatase non-receptor type 3; May act at junctions between the membrane and the cytoskeleton. | 0.473 |
| Dusp26 | Rnf122 | ENSMUSP00000046794 | ENSMUSP00000040478 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability (By similarity). | 0.533 |
| Dusp26 | Smim12 | ENSMUSP00000046794 | ENSMUSP00000131941 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. | Small integral membrane protein 12. | 0.455 |
| Dusp26 | Utp15 | ENSMUSP00000046794 | ENSMUSP00000048204 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. | U3 small nucleolar RNA-associated protein 15 homolog; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. | 0.442 |
| Hdhd5 | Dusp26 | ENSMUSP00000074775 | ENSMUSP00000046794 | Haloacid dehalogenase-like hydrolase domain-containing 5; Belongs to the HAD-like hydrolase superfamily. | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. | 0.643 |
| Hipk2 | Dusp26 | ENSMUSP00000124133 | ENSMUSP00000046794 | Homeodomain-interacting protein kinase 2; Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect [...] | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. | 0.574 |
| Mthfsd | Def8 | ENSMUSP00000112116 | ENSMUSP00000104460 | Methenyltetrahydrofolate synthase domain-containing protein. | Differentially expressed in FDCP 8; Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts. Involved in bone resorption. | 0.646 |
| Mthfsd | Dusp26 | ENSMUSP00000112116 | ENSMUSP00000046794 | Methenyltetrahydrofolate synthase domain-containing protein. | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. | 0.445 |
| Mthfsd | Npas4 | ENSMUSP00000112116 | ENSMUSP00000062992 | Methenyltetrahydrofolate synthase domain-containing protein. | Neuronal PAS domain-containing protein 4; Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hyppocampus. Plays a key role in the structural and functional plasticity of neurons. Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activ [...] | 0.636 |
| Mthfsd | Smim12 | ENSMUSP00000112116 | ENSMUSP00000131941 | Methenyltetrahydrofolate synthase domain-containing protein. | Small integral membrane protein 12. | 0.783 |
| Mthfsd | Utp15 | ENSMUSP00000112116 | ENSMUSP00000048204 | Methenyltetrahydrofolate synthase domain-containing protein. | U3 small nucleolar RNA-associated protein 15 homolog; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. | 0.768 |
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