node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Adamts2 | Olfml2b | ENSMUSP00000040171 | ENSMUSP00000047291 | A disintegrin and metalloproteinase with thrombospondin motifs 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly (By similarity). Does not act on type III collagen (By similarity). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity (By similarity). | Olfactomedin-like protein 2B. | 0.457 |
Adamts2 | Sec16b | ENSMUSP00000040171 | ENSMUSP00000083300 | A disintegrin and metalloproteinase with thrombospondin motifs 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly (By similarity). Does not act on type III collagen (By similarity). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity (By similarity). | Protein transport protein Sec16B; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes; Belongs to the SEC16 family. | 0.505 |
Cep350 | Gm7694 | ENSMUSP00000120085 | ENSMUSP00000136757 | Centrosome-associated protein 350; Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity. Required for ciliation. | Predicted gene 7694. | 0.402 |
Cep350 | Olfml2b | ENSMUSP00000120085 | ENSMUSP00000047291 | Centrosome-associated protein 350; Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity. Required for ciliation. | Olfactomedin-like protein 2B. | 0.490 |
Cep350 | Sec16b | ENSMUSP00000120085 | ENSMUSP00000083300 | Centrosome-associated protein 350; Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity. Required for ciliation. | Protein transport protein Sec16B; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes; Belongs to the SEC16 family. | 0.449 |
Cep350 | Tdrd5 | ENSMUSP00000120085 | ENSMUSP00000137298 | Centrosome-associated protein 350; Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity. Required for ciliation. | Tudor domain-containing protein 5; Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly. Belongs to the TDRD5 family. | 0.449 |
Cep350 | Tor1aip1 | ENSMUSP00000120085 | ENSMUSP00000095134 | Centrosome-associated protein 350; Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity. Required for ciliation. | Torsin-1A-interacting protein 1; Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. | 0.612 |
Cep350 | Tor3a | ENSMUSP00000120085 | ENSMUSP00000078572 | Centrosome-associated protein 350; Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity. Required for ciliation. | Torsin-3A. | 0.498 |
Dusp12 | Olfml2b | ENSMUSP00000027970 | ENSMUSP00000047291 | Dual specificity protein phosphatase 12; Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates. | Olfactomedin-like protein 2B. | 0.469 |
Gm5148 | Olfml2b | ENSMUSP00000103740 | ENSMUSP00000047291 | Predicted gene, EG381438. | Olfactomedin-like protein 2B. | 0.483 |
Gm7694 | Cep350 | ENSMUSP00000136757 | ENSMUSP00000120085 | Predicted gene 7694. | Centrosome-associated protein 350; Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity. Required for ciliation. | 0.402 |
Gm7694 | Olfml2b | ENSMUSP00000136757 | ENSMUSP00000047291 | Predicted gene 7694. | Olfactomedin-like protein 2B. | 0.483 |
Ikbip | Olfml2b | ENSMUSP00000020149 | ENSMUSP00000047291 | Inhibitor of nuclear factor kappa-B kinase-interacting protein; Target of p53/TP53 with pro-apoptotic function. | Olfactomedin-like protein 2B. | 0.478 |
Olfml2b | Adamts2 | ENSMUSP00000047291 | ENSMUSP00000040171 | Olfactomedin-like protein 2B. | A disintegrin and metalloproteinase with thrombospondin motifs 2; Cleaves the propeptides of type I and II collagen prior to fibril assembly (By similarity). Does not act on type III collagen (By similarity). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity (By similarity). | 0.457 |
Olfml2b | Cep350 | ENSMUSP00000047291 | ENSMUSP00000120085 | Olfactomedin-like protein 2B. | Centrosome-associated protein 350; Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity. Required for ciliation. | 0.490 |
Olfml2b | Dusp12 | ENSMUSP00000047291 | ENSMUSP00000027970 | Olfactomedin-like protein 2B. | Dual specificity protein phosphatase 12; Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Can dephosphorylate glucokinase (in vitro). Has phosphatase activity with the synthetic substrate 6,8-difluoro-4-methylumbelliferyl phosphate and other in vitro substrates. | 0.469 |
Olfml2b | Gm5148 | ENSMUSP00000047291 | ENSMUSP00000103740 | Olfactomedin-like protein 2B. | Predicted gene, EG381438. | 0.483 |
Olfml2b | Gm7694 | ENSMUSP00000047291 | ENSMUSP00000136757 | Olfactomedin-like protein 2B. | Predicted gene 7694. | 0.483 |
Olfml2b | Ikbip | ENSMUSP00000047291 | ENSMUSP00000020149 | Olfactomedin-like protein 2B. | Inhibitor of nuclear factor kappa-B kinase-interacting protein; Target of p53/TP53 with pro-apoptotic function. | 0.478 |
Olfml2b | Sec16b | ENSMUSP00000047291 | ENSMUSP00000083300 | Olfactomedin-like protein 2B. | Protein transport protein Sec16B; Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. Involved in peroxisome biogenesis. Regulates the transport of peroxisomal biogenesis factors PEX3 and PEX16 from the ER to peroxisomes; Belongs to the SEC16 family. | 0.461 |