node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ciita | Clec16a | ENSMUSP00000023147 | ENSMUSP00000065423 | MHC class II transactivator; Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription, the promoter element requirem [...] | Protein CLEC16A; Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health. | 0.648 |
Ciita | Dexi | ENSMUSP00000023147 | ENSMUSP00000139108 | MHC class II transactivator; Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription, the promoter element requirem [...] | Dexamethasone-induced protein; Belongs to the DEXI family. | 0.588 |
Ciita | Rfxap | ENSMUSP00000023147 | ENSMUSP00000040917 | MHC class II transactivator; Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription, the promoter element requirem [...] | Regulatory factor X-associated protein; Part of the RFX complex that binds to the X-box of MHC II promoters. | 0.989 |
Clec16a | Ciita | ENSMUSP00000065423 | ENSMUSP00000023147 | Protein CLEC16A; Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health. | MHC class II transactivator; Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription, the promoter element requirem [...] | 0.648 |
Clec16a | Dexi | ENSMUSP00000065423 | ENSMUSP00000139108 | Protein CLEC16A; Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health. | Dexamethasone-induced protein; Belongs to the DEXI family. | 0.800 |
Dexi | Ciita | ENSMUSP00000139108 | ENSMUSP00000023147 | Dexamethasone-induced protein; Belongs to the DEXI family. | MHC class II transactivator; Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription, the promoter element requirem [...] | 0.588 |
Dexi | Clec16a | ENSMUSP00000139108 | ENSMUSP00000065423 | Dexamethasone-induced protein; Belongs to the DEXI family. | Protein CLEC16A; Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteosomal degradation, RNF41/NRDP1 which regulates proteosomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health. | 0.800 |
Dexi | Gpr139 | ENSMUSP00000139108 | ENSMUSP00000081700 | Dexamethasone-induced protein; Belongs to the DEXI family. | Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway. | 0.549 |
Dexi | Kctd2 | ENSMUSP00000139108 | ENSMUSP00000099324 | Dexamethasone-induced protein; Belongs to the DEXI family. | BTB/POZ domain-containing protein KCTD2. | 0.685 |
Dexi | Map6d1 | ENSMUSP00000139108 | ENSMUSP00000043332 | Dexamethasone-induced protein; Belongs to the DEXI family. | MAP6 domain-containing protein 1; May have microtubule-stabilizing activity. | 0.513 |
Dexi | Mrps28 | ENSMUSP00000139108 | ENSMUSP00000038305 | Dexamethasone-induced protein; Belongs to the DEXI family. | 28S ribosomal protein S28, mitochondrial; Belongs to the bacterial ribosomal protein bS1 family. | 0.629 |
Dexi | Rd3l | ENSMUSP00000139108 | ENSMUSP00000140454 | Dexamethasone-induced protein; Belongs to the DEXI family. | Retinal degeneration 3-like. | 0.683 |
Dexi | Rfxap | ENSMUSP00000139108 | ENSMUSP00000040917 | Dexamethasone-induced protein; Belongs to the DEXI family. | Regulatory factor X-associated protein; Part of the RFX complex that binds to the X-box of MHC II promoters. | 0.538 |
Dexi | Rmi2 | ENSMUSP00000139108 | ENSMUSP00000042676 | Dexamethasone-induced protein; Belongs to the DEXI family. | RecQ-mediated genome instability protein 2; Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM. | 0.676 |
Dexi | Zc3h7a | ENSMUSP00000139108 | ENSMUSP00000041308 | Dexamethasone-induced protein; Belongs to the DEXI family. | Zinc finger CCCH type-containing 7 A. | 0.595 |
Gpr139 | Dexi | ENSMUSP00000081700 | ENSMUSP00000139108 | Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway. | Dexamethasone-induced protein; Belongs to the DEXI family. | 0.549 |
Gpr139 | Map6d1 | ENSMUSP00000081700 | ENSMUSP00000043332 | Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway. | MAP6 domain-containing protein 1; May have microtubule-stabilizing activity. | 0.465 |
Gpr139 | Rd3l | ENSMUSP00000081700 | ENSMUSP00000140454 | Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway. | Retinal degeneration 3-like. | 0.670 |
Gpr139 | Rfxap | ENSMUSP00000081700 | ENSMUSP00000040917 | Probable G-protein coupled receptor 139; Orphan receptor. Seems to act through a G(q/11)-mediated pathway. | Regulatory factor X-associated protein; Part of the RFX complex that binds to the X-box of MHC II promoters. | 0.446 |
Kctd2 | Dexi | ENSMUSP00000099324 | ENSMUSP00000139108 | BTB/POZ domain-containing protein KCTD2. | Dexamethasone-induced protein; Belongs to the DEXI family. | 0.685 |