node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ak9 | Dck | ENSMUSP00000134177 | ENSMUSP00000031311 | Adenylate kinase 9. | Deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). | 0.910 |
Ak9 | Dctpp1 | ENSMUSP00000134177 | ENSMUSP00000047845 | Adenylate kinase 9. | dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. | 0.919 |
Ak9 | Nme1 | ENSMUSP00000134177 | ENSMUSP00000117022 | Adenylate kinase 9. | Nucleoside diphosphate kinase A; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for n [...] | 0.925 |
Ak9 | Nme2 | ENSMUSP00000134177 | ENSMUSP00000021217 | Adenylate kinase 9. | Nucleoside diphosphate kinase B; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE I [...] | 0.925 |
Ak9 | Nme6 | ENSMUSP00000134177 | ENSMUSP00000035053 | Adenylate kinase 9. | Nucleoside diphosphate kinase 6; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.925 |
Ak9 | Nt5m | ENSMUSP00000134177 | ENSMUSP00000099756 | Adenylate kinase 9. | 5'(3')-deoxyribonucleotidase, mitochondrial; Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP; Belongs to the 5'(3')-deoxyribonucleotidase family. | 0.667 |
Ak9 | Rrm1 | ENSMUSP00000134177 | ENSMUSP00000033283 | Adenylate kinase 9. | Ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase large chain family. | 0.711 |
Ak9 | Rrm2 | ENSMUSP00000134177 | ENSMUSP00000020980 | Adenylate kinase 9. | Ribonucleoside-diphosphate reductase subunit M2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling (By similarity). Belongs to the ribonucleoside diphosphate reductase small chain family. | 0.659 |
Ak9 | Rrm2b | ENSMUSP00000134177 | ENSMUSP00000022901 | Adenylate kinase 9. | Ribonucleoside-diphosphate reductase subunit M2 B; Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. | 0.661 |
Dck | Ak9 | ENSMUSP00000031311 | ENSMUSP00000134177 | Deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). | Adenylate kinase 9. | 0.910 |
Dck | Dctd | ENSMUSP00000031311 | ENSMUSP00000126733 | Deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | 0.978 |
Dck | Dctpp1 | ENSMUSP00000031311 | ENSMUSP00000047845 | Deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). | dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. | 0.931 |
Dck | Nt5m | ENSMUSP00000031311 | ENSMUSP00000099756 | Deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). | 5'(3')-deoxyribonucleotidase, mitochondrial; Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP; Belongs to the 5'(3')-deoxyribonucleotidase family. | 0.937 |
Dck | Rrm1 | ENSMUSP00000031311 | ENSMUSP00000033283 | Deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). | Ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase large chain family. | 0.803 |
Dck | Rrm2 | ENSMUSP00000031311 | ENSMUSP00000020980 | Deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). | Ribonucleoside-diphosphate reductase subunit M2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling (By similarity). Belongs to the ribonucleoside diphosphate reductase small chain family. | 0.767 |
Dck | Rrm2b | ENSMUSP00000031311 | ENSMUSP00000022901 | Deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). | Ribonucleoside-diphosphate reductase subunit M2 B; Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. | 0.597 |
Dctd | Dck | ENSMUSP00000126733 | ENSMUSP00000031311 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | Deoxycytidine kinase; Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). | 0.978 |
Dctd | Dctpp1 | ENSMUSP00000126733 | ENSMUSP00000047845 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. | 0.958 |
Dctd | Nt5m | ENSMUSP00000126733 | ENSMUSP00000099756 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | 5'(3')-deoxyribonucleotidase, mitochondrial; Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP; Belongs to the 5'(3')-deoxyribonucleotidase family. | 0.906 |
Dctd | Rrm1 | ENSMUSP00000126733 | ENSMUSP00000033283 | Deoxycytidylate deaminase; Supplies the nucleotide substrate for thymidylate synthetase. | Ribonucleoside-diphosphate reductase large subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase large chain family. | 0.550 |