| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Arhgef37 | Fchsd1 | ENSMUSP00000130560 | ENSMUSP00000047878 | Rho guanine nucleotide exchange factor 37; May act as a guanine nucleotide exchange factor (GEF). | F-BAR and double SH3 domains protein 1; Promotes actin polymerization mediated by SNX9 and WASL. | 0.624 |
| Fchsd1 | Arhgef37 | ENSMUSP00000047878 | ENSMUSP00000130560 | F-BAR and double SH3 domains protein 1; Promotes actin polymerization mediated by SNX9 and WASL. | Rho guanine nucleotide exchange factor 37; May act as a guanine nucleotide exchange factor (GEF). | 0.624 |
| Fchsd1 | Fnbp1 | ENSMUSP00000047878 | ENSMUSP00000109190 | F-BAR and double SH3 domains protein 1; Promotes actin polymerization mediated by SNX9 and WASL. | Formin-binding protein 1; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May act as a link between RND2 signaling and regulation of the [...] | 0.713 |
| Fchsd1 | Fnbp4 | ENSMUSP00000047878 | ENSMUSP00000013759 | F-BAR and double SH3 domains protein 1; Promotes actin polymerization mediated by SNX9 and WASL. | Formin-binding protein 4. | 0.621 |
| Fchsd1 | Itsn2 | ENSMUSP00000047878 | ENSMUSP00000052758 | F-BAR and double SH3 domains protein 1; Promotes actin polymerization mediated by SNX9 and WASL. | Intersectin-2; Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes. | 0.635 |
| Fchsd1 | Rell2 | ENSMUSP00000047878 | ENSMUSP00000135556 | F-BAR and double SH3 domains protein 1; Promotes actin polymerization mediated by SNX9 and WASL. | RELT-like protein 2; Induces activation of MAPK14/p38 cascade, when overexpressed. Induces apoptosis, when overexpressed. | 0.662 |
| Fchsd1 | Snx18 | ENSMUSP00000047878 | ENSMUSP00000104864 | F-BAR and double SH3 domains protein 1; Promotes actin polymerization mediated by SNX9 and WASL. | Sorting nexin-18; Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis (By similarity). Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Stimulates the GTPase activity of DNM2. P [...] | 0.677 |
| Fchsd1 | Snx33 | ENSMUSP00000047878 | ENSMUSP00000060225 | F-BAR and double SH3 domains protein 1; Promotes actin polymerization mediated by SNX9 and WASL. | Sorting nexin-33; Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macr [...] | 0.665 |
| Fchsd1 | Snx9 | ENSMUSP00000047878 | ENSMUSP00000002436 | F-BAR and double SH3 domains protein 1; Promotes actin polymerization mediated by SNX9 and WASL. | Sorting nexin-9; Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin- independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promo [...] | 0.648 |
| Fchsd1 | Was | ENSMUSP00000047878 | ENSMUSP00000033505 | F-BAR and double SH3 domains protein 1; Promotes actin polymerization mediated by SNX9 and WASL. | Wiskott-Aldrich syndrome protein homolog; Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria. In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. Promotes homologous recombinatio [...] | 0.669 |
| Fchsd1 | Wasl | ENSMUSP00000047878 | ENSMUSP00000031695 | F-BAR and double SH3 domains protein 1; Promotes actin polymerization mediated by SNX9 and WASL. | Neural Wiskott-Aldrich syndrome protein; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (By similarity). Binds to HSF1/HS [...] | 0.656 |
| Fnbp1 | Fchsd1 | ENSMUSP00000109190 | ENSMUSP00000047878 | Formin-binding protein 1; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May act as a link between RND2 signaling and regulation of the [...] | F-BAR and double SH3 domains protein 1; Promotes actin polymerization mediated by SNX9 and WASL. | 0.713 |
| Fnbp1 | Fnbp4 | ENSMUSP00000109190 | ENSMUSP00000013759 | Formin-binding protein 1; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May act as a link between RND2 signaling and regulation of the [...] | Formin-binding protein 4. | 0.582 |
| Fnbp1 | Itsn2 | ENSMUSP00000109190 | ENSMUSP00000052758 | Formin-binding protein 1; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May act as a link between RND2 signaling and regulation of the [...] | Intersectin-2; Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes. | 0.751 |
| Fnbp1 | Snx9 | ENSMUSP00000109190 | ENSMUSP00000002436 | Formin-binding protein 1; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May act as a link between RND2 signaling and regulation of the [...] | Sorting nexin-9; Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin- independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promo [...] | 0.548 |
| Fnbp1 | Was | ENSMUSP00000109190 | ENSMUSP00000033505 | Formin-binding protein 1; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May act as a link between RND2 signaling and regulation of the [...] | Wiskott-Aldrich syndrome protein homolog; Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria. In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. Promotes homologous recombinatio [...] | 0.806 |
| Fnbp1 | Wasl | ENSMUSP00000109190 | ENSMUSP00000031695 | Formin-binding protein 1; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May act as a link between RND2 signaling and regulation of the [...] | Neural Wiskott-Aldrich syndrome protein; Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization. Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (By similarity). Binds to HSF1/HS [...] | 0.846 |
| Fnbp4 | Fchsd1 | ENSMUSP00000013759 | ENSMUSP00000047878 | Formin-binding protein 4. | F-BAR and double SH3 domains protein 1; Promotes actin polymerization mediated by SNX9 and WASL. | 0.621 |
| Fnbp4 | Fnbp1 | ENSMUSP00000013759 | ENSMUSP00000109190 | Formin-binding protein 4. | Formin-binding protein 1; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May act as a link between RND2 signaling and regulation of the [...] | 0.582 |
| Itsn2 | Fchsd1 | ENSMUSP00000052758 | ENSMUSP00000047878 | Intersectin-2; Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes. | F-BAR and double SH3 domains protein 1; Promotes actin polymerization mediated by SNX9 and WASL. | 0.635 |
