node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Capn10 | Capn3 | ENSMUSP00000027488 | ENSMUSP00000028749 | Calpain-10; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin- stimulated glucose uptake (By similarity). | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | 0.483 |
Capn10 | Capn5 | ENSMUSP00000027488 | ENSMUSP00000048183 | Calpain-10; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin- stimulated glucose uptake (By similarity). | Calpain-5; Calcium-regulated non-lysosomal thiol-protease. | 0.493 |
Capn10 | Capns1 | ENSMUSP00000027488 | ENSMUSP00000001845 | Calpain-10; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin- stimulated glucose uptake (By similarity). | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | 0.818 |
Capn10 | Capns2 | ENSMUSP00000027488 | ENSMUSP00000100553 | Calpain-10; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin- stimulated glucose uptake (By similarity). | Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity (By similarity). | 0.794 |
Capn10 | Cast | ENSMUSP00000027488 | ENSMUSP00000065275 | Calpain-10; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin- stimulated glucose uptake (By similarity). | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family. | 0.795 |
Capn10 | Lrguk | ENSMUSP00000027488 | ENSMUSP00000065146 | Calpain-10; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin- stimulated glucose uptake (By similarity). | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. | 0.451 |
Capn3 | Capn10 | ENSMUSP00000028749 | ENSMUSP00000027488 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | Calpain-10; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin- stimulated glucose uptake (By similarity). | 0.483 |
Capn3 | Capn5 | ENSMUSP00000028749 | ENSMUSP00000048183 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | Calpain-5; Calcium-regulated non-lysosomal thiol-protease. | 0.660 |
Capn3 | Capns1 | ENSMUSP00000028749 | ENSMUSP00000001845 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | 0.706 |
Capn3 | Capns2 | ENSMUSP00000028749 | ENSMUSP00000100553 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity (By similarity). | 0.705 |
Capn3 | Cast | ENSMUSP00000028749 | ENSMUSP00000065275 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family. | 0.870 |
Capn3 | Lrguk | ENSMUSP00000028749 | ENSMUSP00000065146 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. | 0.451 |
Capn5 | Capn10 | ENSMUSP00000048183 | ENSMUSP00000027488 | Calpain-5; Calcium-regulated non-lysosomal thiol-protease. | Calpain-10; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin- stimulated glucose uptake (By similarity). | 0.493 |
Capn5 | Capn3 | ENSMUSP00000048183 | ENSMUSP00000028749 | Calpain-5; Calcium-regulated non-lysosomal thiol-protease. | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | 0.660 |
Capn5 | Capns1 | ENSMUSP00000048183 | ENSMUSP00000001845 | Calpain-5; Calcium-regulated non-lysosomal thiol-protease. | Calpain small subunit 1; Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. | 0.866 |
Capn5 | Capns2 | ENSMUSP00000048183 | ENSMUSP00000100553 | Calpain-5; Calcium-regulated non-lysosomal thiol-protease. | Calpain small subunit 2; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity (By similarity). | 0.864 |
Capn5 | Cast | ENSMUSP00000048183 | ENSMUSP00000065275 | Calpain-5; Calcium-regulated non-lysosomal thiol-protease. | Calpastatin; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue; Belongs to the protease inhibitor I27 (calpastatin) family. | 0.738 |
Capn5 | Cblb | ENSMUSP00000048183 | ENSMUSP00000110115 | Calpain-5; Calcium-regulated non-lysosomal thiol-protease. | E3 ubiquitin-protein ligase CBL-B; E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs [...] | 0.530 |
Capn5 | Fem1a | ENSMUSP00000048183 | ENSMUSP00000057996 | Calpain-5; Calcium-regulated non-lysosomal thiol-protease. | Protein fem-1 homolog A-A; Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. May participate in antiinflammatory signaling via its interaction with PTGER4 (By similarity); Belongs to the fem-1 family. | 0.536 |
Capn5 | Fem1b | ENSMUSP00000048183 | ENSMUSP00000034775 | Calpain-5; Calcium-regulated non-lysosomal thiol-protease. | Protein fem-1 homolog B; Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1 (By similarity); Belongs to the fem-1 family. | 0.492 |