node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Agbl2 | Cpa4 | ENSMUSP00000129216 | ENSMUSP00000048558 | Cytosolic carboxypeptidase 2; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin. | Carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway. Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val; Belongs to the peptidase M14 family. | 0.485 |
Agbl2 | Lxn | ENSMUSP00000129216 | ENSMUSP00000060732 | Cytosolic carboxypeptidase 2; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin. | Latexin; Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4 (By similarity). May play a role in inflammation. Belongs to the protease inhibitor I47 (latexin) family. | 0.720 |
Cela2a | Cela3a | ENSMUSP00000099539 | ENSMUSP00000024200 | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. | Chymotrypsin-like elastase family, member 3A; Belongs to the peptidase S1 family. | 0.938 |
Cela2a | Cela3b | ENSMUSP00000099539 | ENSMUSP00000099581 | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. | Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity; Belongs to the peptidase S1 family. Elastase subfamily. | 0.998 |
Cela2a | Cpa4 | ENSMUSP00000099539 | ENSMUSP00000048558 | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. | Carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway. Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val; Belongs to the peptidase M14 family. | 0.472 |
Cela2a | Ctrc | ENSMUSP00000099539 | ENSMUSP00000039879 | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. | Chymotrypsin-C; Has chymotrypsin-type protease activity and hypocalcemic activity; Belongs to the peptidase S1 family. Elastase subfamily. | 0.595 |
Cela2a | Ppy | ENSMUSP00000099539 | ENSMUSP00000017460 | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. | Pancreatic prohormone; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions. | 0.721 |
Cela3a | Cela2a | ENSMUSP00000024200 | ENSMUSP00000099539 | Chymotrypsin-like elastase family, member 3A; Belongs to the peptidase S1 family. | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. | 0.938 |
Cela3a | Cela3b | ENSMUSP00000024200 | ENSMUSP00000099581 | Chymotrypsin-like elastase family, member 3A; Belongs to the peptidase S1 family. | Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity; Belongs to the peptidase S1 family. Elastase subfamily. | 0.906 |
Cela3a | Cpa4 | ENSMUSP00000024200 | ENSMUSP00000048558 | Chymotrypsin-like elastase family, member 3A; Belongs to the peptidase S1 family. | Carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway. Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val; Belongs to the peptidase M14 family. | 0.432 |
Cela3a | Ppy | ENSMUSP00000024200 | ENSMUSP00000017460 | Chymotrypsin-like elastase family, member 3A; Belongs to the peptidase S1 family. | Pancreatic prohormone; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions. | 0.705 |
Cela3b | Cela2a | ENSMUSP00000099581 | ENSMUSP00000099539 | Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity; Belongs to the peptidase S1 family. Elastase subfamily. | Chymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. | 0.998 |
Cela3b | Cela3a | ENSMUSP00000099581 | ENSMUSP00000024200 | Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity; Belongs to the peptidase S1 family. Elastase subfamily. | Chymotrypsin-like elastase family, member 3A; Belongs to the peptidase S1 family. | 0.906 |
Cela3b | Cpa4 | ENSMUSP00000099581 | ENSMUSP00000048558 | Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity; Belongs to the peptidase S1 family. Elastase subfamily. | Carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway. Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val; Belongs to the peptidase M14 family. | 0.432 |
Cela3b | Ctrc | ENSMUSP00000099581 | ENSMUSP00000039879 | Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity; Belongs to the peptidase S1 family. Elastase subfamily. | Chymotrypsin-C; Has chymotrypsin-type protease activity and hypocalcemic activity; Belongs to the peptidase S1 family. Elastase subfamily. | 0.754 |
Cela3b | Ppy | ENSMUSP00000099581 | ENSMUSP00000017460 | Chymotrypsin-like elastase family member 3B; Efficient protease with alanine specificity but only little elastolytic activity; Belongs to the peptidase S1 family. Elastase subfamily. | Pancreatic prohormone; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions. | 0.728 |
Copg2 | Cpa4 | ENSMUSP00000038368 | ENSMUSP00000048558 | Coatomer subunit gamma-2; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also i [...] | Carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway. Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val; Belongs to the peptidase M14 family. | 0.461 |
Copg2 | Dlk1 | ENSMUSP00000038368 | ENSMUSP00000063104 | Coatomer subunit gamma-2; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also i [...] | Protein delta homolog 1; May have a role in neuroendocrine differentiation. Inhibits adipocyte differentiation. | 0.483 |
Copg2 | Grb10 | ENSMUSP00000038368 | ENSMUSP00000091011 | Coatomer subunit gamma-2; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also i [...] | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] | 0.505 |
Cpa4 | Agbl2 | ENSMUSP00000048558 | ENSMUSP00000129216 | Carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway. Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val; Belongs to the peptidase M14 family. | Cytosolic carboxypeptidase 2; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of tubulin. | 0.485 |