node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cdrt4 | Pdik1l | ENSMUSP00000048844 | ENSMUSP00000060381 | CMT1A duplicated region transcript 4 protein homolog. | Serine/threonine-protein kinase PDIK1L. | 0.428 |
Cdrt4 | Tekt3 | ENSMUSP00000048844 | ENSMUSP00000042063 | CMT1A duplicated region transcript 4 protein homolog. | Tektin-3; May be a structural component of the sperm flagellum. Required for normal sperm mobility; Belongs to the tektin family. | 0.510 |
Cdrt4 | Tvp23b | ENSMUSP00000048844 | ENSMUSP00000014321 | CMT1A duplicated region transcript 4 protein homolog. | Golgi apparatus membrane protein TVP23 homolog B. | 0.473 |
Cdrt4 | Ulk1 | ENSMUSP00000048844 | ENSMUSP00000143536 | CMT1A duplicated region transcript 4 protein homolog. | Serine/threonine-protein kinase ULK1; Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leadi [...] | 0.559 |
Cdrt4 | Ulk2 | ENSMUSP00000048844 | ENSMUSP00000004920 | CMT1A duplicated region transcript 4 protein homolog. | Serine/threonine-protein kinase ULK2; Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1 [...] | 0.559 |
Cdrt4 | Ulk3 | ENSMUSP00000048844 | ENSMUSP00000059947 | CMT1A duplicated region transcript 4 protein homolog. | Serine/threonine-protein kinase ULK3; Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as we [...] | 0.428 |
Cdrt4 | Yipf1 | ENSMUSP00000048844 | ENSMUSP00000075113 | CMT1A duplicated region transcript 4 protein homolog. | Protein YIPF1; Belongs to the YIP1 family. | 0.477 |
Cdrt4 | Yipf2 | ENSMUSP00000048844 | ENSMUSP00000034700 | CMT1A duplicated region transcript 4 protein homolog. | Protein YIPF2; Belongs to the YIP1 family. | 0.477 |
Cdrt4 | Zfp286 | ENSMUSP00000048844 | ENSMUSP00000055517 | CMT1A duplicated region transcript 4 protein homolog. | Zinc finger protein 286. | 0.444 |
Cdrt4 | Zfp287 | ENSMUSP00000048844 | ENSMUSP00000141046 | CMT1A duplicated region transcript 4 protein homolog. | Zinc finger protein 287; May be involved in transcriptional regulation. | 0.606 |
Pdik1l | Cdrt4 | ENSMUSP00000060381 | ENSMUSP00000048844 | Serine/threonine-protein kinase PDIK1L. | CMT1A duplicated region transcript 4 protein homolog. | 0.428 |
Pdik1l | Tvp23b | ENSMUSP00000060381 | ENSMUSP00000014321 | Serine/threonine-protein kinase PDIK1L. | Golgi apparatus membrane protein TVP23 homolog B. | 0.432 |
Tekt3 | Cdrt4 | ENSMUSP00000042063 | ENSMUSP00000048844 | Tektin-3; May be a structural component of the sperm flagellum. Required for normal sperm mobility; Belongs to the tektin family. | CMT1A duplicated region transcript 4 protein homolog. | 0.510 |
Tvp23b | Cdrt4 | ENSMUSP00000014321 | ENSMUSP00000048844 | Golgi apparatus membrane protein TVP23 homolog B. | CMT1A duplicated region transcript 4 protein homolog. | 0.473 |
Tvp23b | Pdik1l | ENSMUSP00000014321 | ENSMUSP00000060381 | Golgi apparatus membrane protein TVP23 homolog B. | Serine/threonine-protein kinase PDIK1L. | 0.432 |
Tvp23b | Ulk1 | ENSMUSP00000014321 | ENSMUSP00000143536 | Golgi apparatus membrane protein TVP23 homolog B. | Serine/threonine-protein kinase ULK1; Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leadi [...] | 0.559 |
Tvp23b | Ulk2 | ENSMUSP00000014321 | ENSMUSP00000004920 | Golgi apparatus membrane protein TVP23 homolog B. | Serine/threonine-protein kinase ULK2; Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1 [...] | 0.559 |
Tvp23b | Ulk3 | ENSMUSP00000014321 | ENSMUSP00000059947 | Golgi apparatus membrane protein TVP23 homolog B. | Serine/threonine-protein kinase ULK3; Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as we [...] | 0.428 |
Tvp23b | Yipf1 | ENSMUSP00000014321 | ENSMUSP00000075113 | Golgi apparatus membrane protein TVP23 homolog B. | Protein YIPF1; Belongs to the YIP1 family. | 0.501 |
Tvp23b | Yipf2 | ENSMUSP00000014321 | ENSMUSP00000034700 | Golgi apparatus membrane protein TVP23 homolog B. | Protein YIPF2; Belongs to the YIP1 family. | 0.505 |