node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Casp1 | Csta1 | ENSMUSP00000027015 | ENSMUSP00000093795 | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically [...] | Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family. | 0.797 |
Casp1 | Cstdc5 | ENSMUSP00000027015 | ENSMUSP00000093794 | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically [...] | Cystatin domain-containing 5. | 0.720 |
Casp1 | Ctsb | ENSMUSP00000027015 | ENSMUSP00000006235 | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically [...] | Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen. Has also been implicated in tumor invasion and metastasis (By similarity). Belongs to the peptidase C1 family. | 0.948 |
Casp1 | Ctss | ENSMUSP00000027015 | ENSMUSP00000015667 | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically [...] | Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L; Belongs to the peptidase C1 family. | 0.726 |
Casp1 | Plau | ENSMUSP00000027015 | ENSMUSP00000022368 | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically [...] | Urokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin; Belongs to the peptidase S1 family. | 0.779 |
Casp1 | Serpinb6a | ENSMUSP00000027015 | ENSMUSP00000017188 | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically [...] | Serpin B6; Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress. May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. | 0.858 |
Casp1 | Serpine1 | ENSMUSP00000027015 | ENSMUSP00000039586 | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically [...] | Plasminogen activator inhibitor 1; Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase- type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair (B [...] | 0.807 |
Casp1 | Stfa2l1 | ENSMUSP00000027015 | ENSMUSP00000078181 | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically [...] | Stefin-2; This is an intracellular thiol proteinase inhibitor. | 0.796 |
Casp1 | Stfa3 | ENSMUSP00000027015 | ENSMUSP00000067445 | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically [...] | Stefin-3; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family. | 0.720 |
Csta1 | Casp1 | ENSMUSP00000093795 | ENSMUSP00000027015 | Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family. | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically [...] | 0.797 |
Csta1 | Cstdc5 | ENSMUSP00000093795 | ENSMUSP00000093794 | Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family. | Cystatin domain-containing 5. | 0.743 |
Csta1 | Ctsb | ENSMUSP00000093795 | ENSMUSP00000006235 | Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family. | Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen. Has also been implicated in tumor invasion and metastasis (By similarity). Belongs to the peptidase C1 family. | 0.937 |
Csta1 | Ctsh | ENSMUSP00000093795 | ENSMUSP00000034915 | Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family. | Cathepsin H heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family. | 0.780 |
Csta1 | Ctss | ENSMUSP00000093795 | ENSMUSP00000015667 | Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family. | Cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L; Belongs to the peptidase C1 family. | 0.779 |
Csta1 | Plau | ENSMUSP00000093795 | ENSMUSP00000022368 | Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family. | Urokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin; Belongs to the peptidase S1 family. | 0.749 |
Csta1 | Serpinb6a | ENSMUSP00000093795 | ENSMUSP00000017188 | Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family. | Serpin B6; Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress. May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. | 0.752 |
Csta1 | Serpine1 | ENSMUSP00000093795 | ENSMUSP00000039586 | Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family. | Plasminogen activator inhibitor 1; Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase- type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair (B [...] | 0.746 |
Csta1 | Stfa2l1 | ENSMUSP00000093795 | ENSMUSP00000078181 | Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family. | Stefin-2; This is an intracellular thiol proteinase inhibitor. | 0.763 |
Csta1 | Stfa3 | ENSMUSP00000093795 | ENSMUSP00000067445 | Cystatin-A; This is an intracellular thiol proteinase inhibitor. Belongs to the cystatin family. | Stefin-3; This is an intracellular thiol proteinase inhibitor; Belongs to the cystatin family. | 0.804 |
Cstdc5 | Casp1 | ENSMUSP00000093794 | ENSMUSP00000027015 | Cystatin domain-containing 5. | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis (By similarity). Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically [...] | 0.720 |