node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
4933411K16Rik | Mea1 | ENSMUSP00000131279 | ENSMUSP00000156593 | Uncharacterized protein C10orf62 homolog. | Male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development. | 0.642 |
4933411K16Rik | Plaat5 | ENSMUSP00000131279 | ENSMUSP00000025929 | Uncharacterized protein C10orf62 homolog. | Phospholipase A and acyltransferase 5; Exhibits both phospholipase A1/2 and acyltransferase activities (By similarity). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (By similarity). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N- acylphosphatidylethanolamine (NAPE), which [...] | 0.535 |
4933411K16Rik | Spata4 | ENSMUSP00000131279 | ENSMUSP00000033917 | Uncharacterized protein C10orf62 homolog. | Spermatogenesis-associated protein 4; May play a role in apoptosis regulation. | 0.507 |
4933411K16Rik | Spz1 | ENSMUSP00000131279 | ENSMUSP00000054083 | Uncharacterized protein C10orf62 homolog. | Spermatogenic leucine zipper protein 1; Transcription factor that binds to the DNA sequence 5'- CANNTG-3'(E box) and the G-box motif. Directly binds to a guanine-rich region of the PCNA promoter and up-regulates its expression which in turn induces cell transformation and tumor formation. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis. | 0.497 |
4933411K16Rik | Tcp11x2 | ENSMUSP00000131279 | ENSMUSP00000077676 | Uncharacterized protein C10orf62 homolog. | T-complex 11 family, X-linked 2. | 0.548 |
Fgf21 | Hic1 | ENSMUSP00000033099 | ENSMUSP00000053483 | Fibroblast growth factor 21; Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity probably requires the presence of KLB; Belongs to the heparin-binding growth factors family. | Hypermethylated in cancer 1 protein; Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In c [...] | 0.535 |
Fgf21 | Spz1 | ENSMUSP00000033099 | ENSMUSP00000054083 | Fibroblast growth factor 21; Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity probably requires the presence of KLB; Belongs to the heparin-binding growth factors family. | Spermatogenic leucine zipper protein 1; Transcription factor that binds to the DNA sequence 5'- CANNTG-3'(E box) and the G-box motif. Directly binds to a guanine-rich region of the PCNA promoter and up-regulates its expression which in turn induces cell transformation and tumor formation. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis. | 0.531 |
Hic1 | Fgf21 | ENSMUSP00000053483 | ENSMUSP00000033099 | Hypermethylated in cancer 1 protein; Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In c [...] | Fibroblast growth factor 21; Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity probably requires the presence of KLB; Belongs to the heparin-binding growth factors family. | 0.535 |
Hic1 | Nhlh1 | ENSMUSP00000053483 | ENSMUSP00000057489 | Hypermethylated in cancer 1 protein; Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In c [...] | Helix-loop-helix protein 1; May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system. | 0.568 |
Hic1 | Spz1 | ENSMUSP00000053483 | ENSMUSP00000054083 | Hypermethylated in cancer 1 protein; Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In c [...] | Spermatogenic leucine zipper protein 1; Transcription factor that binds to the DNA sequence 5'- CANNTG-3'(E box) and the G-box motif. Directly binds to a guanine-rich region of the PCNA promoter and up-regulates its expression which in turn induces cell transformation and tumor formation. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis. | 0.610 |
Mea1 | 4933411K16Rik | ENSMUSP00000156593 | ENSMUSP00000131279 | Male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development. | Uncharacterized protein C10orf62 homolog. | 0.642 |
Mea1 | Plaat5 | ENSMUSP00000156593 | ENSMUSP00000025929 | Male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development. | Phospholipase A and acyltransferase 5; Exhibits both phospholipase A1/2 and acyltransferase activities (By similarity). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (By similarity). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N- acylphosphatidylethanolamine (NAPE), which [...] | 0.497 |
Mea1 | Spata4 | ENSMUSP00000156593 | ENSMUSP00000033917 | Male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development. | Spermatogenesis-associated protein 4; May play a role in apoptosis regulation. | 0.487 |
Mea1 | Spz1 | ENSMUSP00000156593 | ENSMUSP00000054083 | Male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development. | Spermatogenic leucine zipper protein 1; Transcription factor that binds to the DNA sequence 5'- CANNTG-3'(E box) and the G-box motif. Directly binds to a guanine-rich region of the PCNA promoter and up-regulates its expression which in turn induces cell transformation and tumor formation. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis. | 0.513 |
Mea1 | Tcp11x2 | ENSMUSP00000156593 | ENSMUSP00000077676 | Male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development. | T-complex 11 family, X-linked 2. | 0.593 |
Nhlh1 | Hic1 | ENSMUSP00000057489 | ENSMUSP00000053483 | Helix-loop-helix protein 1; May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system. | Hypermethylated in cancer 1 protein; Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In c [...] | 0.568 |
Nhlh1 | Spz1 | ENSMUSP00000057489 | ENSMUSP00000054083 | Helix-loop-helix protein 1; May serve as DNA-binding protein and may be involved in the control of cell-type determination, possibly within the developing nervous system. | Spermatogenic leucine zipper protein 1; Transcription factor that binds to the DNA sequence 5'- CANNTG-3'(E box) and the G-box motif. Directly binds to a guanine-rich region of the PCNA promoter and up-regulates its expression which in turn induces cell transformation and tumor formation. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis. | 0.539 |
Plaat5 | 4933411K16Rik | ENSMUSP00000025929 | ENSMUSP00000131279 | Phospholipase A and acyltransferase 5; Exhibits both phospholipase A1/2 and acyltransferase activities (By similarity). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (By similarity). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N- acylphosphatidylethanolamine (NAPE), which [...] | Uncharacterized protein C10orf62 homolog. | 0.535 |
Plaat5 | Mea1 | ENSMUSP00000025929 | ENSMUSP00000156593 | Phospholipase A and acyltransferase 5; Exhibits both phospholipase A1/2 and acyltransferase activities (By similarity). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (By similarity). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N- acylphosphatidylethanolamine (NAPE), which [...] | Male-enhanced antigen 1; May play an important role in spermatogenesis and/or testis development. | 0.497 |
Plaat5 | Spata4 | ENSMUSP00000025929 | ENSMUSP00000033917 | Phospholipase A and acyltransferase 5; Exhibits both phospholipase A1/2 and acyltransferase activities (By similarity). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (By similarity). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N- acylphosphatidylethanolamine (NAPE), which [...] | Spermatogenesis-associated protein 4; May play a role in apoptosis regulation. | 0.610 |