node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cdyl | Rpl23a | ENSMUSP00000074707 | ENSMUSP00000099541 | Chromodomain Y-like protein; [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape. Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing [...] | 60S ribosomal protein L23a; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity); Belongs to the universal ribosomal protein uL23 family. | 0.498 |
Cdyl | Zfp280b | ENSMUSP00000074707 | ENSMUSP00000056340 | Chromodomain Y-like protein; [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape. Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing [...] | Zinc finger protein 280B. | 0.510 |
Cinp | Zfp280b | ENSMUSP00000035245 | ENSMUSP00000056340 | Cyclin-dependent kinase 2-interacting protein; Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling (By similarity). | Zinc finger protein 280B. | 0.624 |
Dnajc18 | Zfp280b | ENSMUSP00000025208 | ENSMUSP00000056340 | DnaJ homolog subfamily C member 18. | Zinc finger protein 280B. | 0.454 |
Dync1li1 | Setd4 | ENSMUSP00000035366 | ENSMUSP00000156723 | Cytoplasmic dynein 1 light intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkp [...] | SET domain-containing protein 4; Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD4 family. | 0.431 |
Dync1li1 | Zfp280b | ENSMUSP00000035366 | ENSMUSP00000056340 | Cytoplasmic dynein 1 light intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkp [...] | Zinc finger protein 280B. | 0.448 |
Hsfy2 | Zfp280b | ENSMUSP00000049715 | ENSMUSP00000056340 | Heat shock transcription factor, Y-linked 2. | Zinc finger protein 280B. | 0.535 |
Rftn1 | Zfp280b | ENSMUSP00000046524 | ENSMUSP00000056340 | Raftlin; Involved in protein trafficking via association with clathrin and AP2 complex (By similarity). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages, and internalization of poly(I:C) to TLR3- positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion. [...] | Zinc finger protein 280B. | 0.430 |
Rpl23a | Cdyl | ENSMUSP00000099541 | ENSMUSP00000074707 | 60S ribosomal protein L23a; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity); Belongs to the universal ribosomal protein uL23 family. | Chromodomain Y-like protein; [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape. Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing [...] | 0.498 |
Rpl23a | Zfp280b | ENSMUSP00000099541 | ENSMUSP00000056340 | 60S ribosomal protein L23a; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity); Belongs to the universal ribosomal protein uL23 family. | Zinc finger protein 280B. | 0.468 |
Setd4 | Dync1li1 | ENSMUSP00000156723 | ENSMUSP00000035366 | SET domain-containing protein 4; Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD4 family. | Cytoplasmic dynein 1 light intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkp [...] | 0.431 |
Setd4 | Zfp280b | ENSMUSP00000156723 | ENSMUSP00000056340 | SET domain-containing protein 4; Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD4 family. | Zinc finger protein 280B. | 0.457 |
Tsga10 | Zfp280b | ENSMUSP00000048859 | ENSMUSP00000056340 | Testis-specific gene 10 protein; Plays a role in spermatogenesis. When overexpressed, prevents nuclear localization of HIF1A ; Belongs to the CEP135/TSGA10 family. | Zinc finger protein 280B. | 0.443 |
Zfp280b | Cdyl | ENSMUSP00000056340 | ENSMUSP00000074707 | Zinc finger protein 280B. | Chromodomain Y-like protein; [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape. Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing [...] | 0.510 |
Zfp280b | Cinp | ENSMUSP00000056340 | ENSMUSP00000035245 | Zinc finger protein 280B. | Cyclin-dependent kinase 2-interacting protein; Interacts with the components of the replication complex and 2 kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling (By similarity). | 0.624 |
Zfp280b | Dnajc18 | ENSMUSP00000056340 | ENSMUSP00000025208 | Zinc finger protein 280B. | DnaJ homolog subfamily C member 18. | 0.454 |
Zfp280b | Dync1li1 | ENSMUSP00000056340 | ENSMUSP00000035366 | Zinc finger protein 280B. | Cytoplasmic dynein 1 light intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkp [...] | 0.448 |
Zfp280b | Hsfy2 | ENSMUSP00000056340 | ENSMUSP00000049715 | Zinc finger protein 280B. | Heat shock transcription factor, Y-linked 2. | 0.535 |
Zfp280b | Rftn1 | ENSMUSP00000056340 | ENSMUSP00000046524 | Zinc finger protein 280B. | Raftlin; Involved in protein trafficking via association with clathrin and AP2 complex (By similarity). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages, and internalization of poly(I:C) to TLR3- positive endosomes in myeloid dendritic cells and epithelial cells; resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion. [...] | 0.430 |
Zfp280b | Rpl23a | ENSMUSP00000056340 | ENSMUSP00000099541 | Zinc finger protein 280B. | 60S ribosomal protein L23a; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity); Belongs to the universal ribosomal protein uL23 family. | 0.468 |