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Ly6e protein (mouse) - STRING interaction network
"Ly6e" - Lymphocyte antigen 6E in Mus musculus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
Ly6eLymphocyte antigen 6E; Involved in T-cell development. Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3-beta-4- containing nAChRs maximum response (136 aa)    
Predicted Functional Partners:
Ly6h
Lymphocyte antigen 6H; Believed to act as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3-beta-4- containing nAChRs maximum response. In vitro inhibits alpha- 3-beta-4-containing nAChRs maximum response. May play a role in the intracellular trafficking of alpha-7-containing nAChRs and may inhibit their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons (By similarity) (160 aa)
         
  0.981
Ly6k
Lymphocyte antigen 6K; Required for sperm migration into the oviduct and male fertility by controlling binding of sperm to zona pellucida. May play a role in cell growth (By similarity) (154 aa)
         
  0.962
Lypd4
Ly6/Plaur domain containing 4 (246 aa)
         
  0.950
Ly6d
Lymphocyte antigen 6D; May act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of B-cell specification (127 aa)
     
 
  0.948
Lypd5
Ly6/Plaur domain containing 5 (256 aa)
         
  0.939
Gpihbp1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1; Plays a key role in the lipolytic processing of chylomicrons. Required for the transport of lipoprotein lipase LPL into the capillary lumen and across endothelial cells (228 aa)
         
  0.939
Lypd2
Ly6/Plaur domain containing 2 (127 aa)
         
  0.933
Spaca4
Sperm acrosome membrane-associated protein 4; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization (127 aa)
         
  0.932
Lypd3
Ly6/PLAUR domain-containing protein 3; Supports cell migration. May be involved in tumor progression (By similarity) (363 aa)
         
  0.929
Lypd6b
Ly6/PLAUR domain-containing protein 6B; Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro acts on nAChRs in a subtype- and stoichiometry-dependent manner. Modulates specifally alpha-3(3)-beta-4(2) nAChRs by enhancing the sensitivity to ACh, decreasing ACh-induced maximal current response and increasing the rate of desensitization to ACh; has no effect on alpha-7 homomeric nAChRs (191 aa)
         
  0.928
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus muscaris, Mus musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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