node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Clcn7 | Gpr107 | ENSMUSP00000035964 | ENSMUSP00000056739 | H(+)/Cl(-) exchange transporter 7; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen. Belongs to the chloride channel (TC 2.A.49) family. ClC- 7/CLCN7 subfamily. | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (By similarity). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | 0.508 |
Gpr107 | Clcn7 | ENSMUSP00000056739 | ENSMUSP00000035964 | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (By similarity). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | H(+)/Cl(-) exchange transporter 7; Slowly voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the lysosome lumen. Belongs to the chloride channel (TC 2.A.49) family. ClC- 7/CLCN7 subfamily. | 0.508 |
Gpr107 | Gpr137b | ENSMUSP00000056739 | ENSMUSP00000021738 | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (By similarity). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | Integral membrane protein GPR137B; Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Involved in the regulation of lysosomal morphology and autophagy (By similarity). Acts also as a negative regulator of osteoclast activity. Involved in interleukin-4-induced M2 macrophage polari [...] | 0.547 |
Gpr107 | Gpr137c | ENSMUSP00000056739 | ENSMUSP00000120015 | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (By similarity). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | G protein-coupled receptor 137C; Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. | 0.502 |
Gpr107 | Gpr146 | ENSMUSP00000056739 | ENSMUSP00000098083 | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (By similarity). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | Probable G-protein coupled receptor 146; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.678 |
Gpr107 | Gpr87 | ENSMUSP00000056739 | ENSMUSP00000143683 | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (By similarity). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | G-protein coupled receptor 87; Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage (By similarity). | 0.471 |
Gpr107 | Lin52 | ENSMUSP00000056739 | ENSMUSP00000133045 | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (By similarity). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | Protein lin-52 homolog. | 0.454 |
Gpr107 | Tmem185a | ENSMUSP00000056739 | ENSMUSP00000099043 | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (By similarity). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | Transmembrane protein 185A. | 0.530 |
Gpr107 | Tpra1 | ENSMUSP00000056739 | ENSMUSP00000063042 | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (By similarity). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | Transmembrane protein adipocyte-associated 1. | 0.493 |
Gpr107 | Txndc11 | ENSMUSP00000056739 | ENSMUSP00000041113 | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (By similarity). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | Thioredoxin domain-containing protein 11; May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation (By similarity). | 0.498 |
Gpr107 | Vmn1r148 | ENSMUSP00000056739 | ENSMUSP00000136142 | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (By similarity). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | Taste receptor type 2. | 0.449 |
Gpr137b | Gpr107 | ENSMUSP00000021738 | ENSMUSP00000056739 | Integral membrane protein GPR137B; Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Involved in the regulation of lysosomal morphology and autophagy (By similarity). Acts also as a negative regulator of osteoclast activity. Involved in interleukin-4-induced M2 macrophage polari [...] | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (By similarity). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | 0.547 |
Gpr137b | Tmem185a | ENSMUSP00000021738 | ENSMUSP00000099043 | Integral membrane protein GPR137B; Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome. Involved in the regulation of lysosomal morphology and autophagy (By similarity). Acts also as a negative regulator of osteoclast activity. Involved in interleukin-4-induced M2 macrophage polari [...] | Transmembrane protein 185A. | 0.474 |
Gpr137c | Gpr107 | ENSMUSP00000120015 | ENSMUSP00000056739 | G protein-coupled receptor 137C; Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (By similarity). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | 0.502 |
Gpr137c | Tmem185a | ENSMUSP00000120015 | ENSMUSP00000099043 | G protein-coupled receptor 137C; Lysosomal integral membrane protein that may regulate MTORC1 complex translocation to lysosomes. | Transmembrane protein 185A. | 0.617 |
Gpr146 | Gpr107 | ENSMUSP00000098083 | ENSMUSP00000056739 | Probable G-protein coupled receptor 146; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (By similarity). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | 0.678 |
Gpr146 | Lin52 | ENSMUSP00000098083 | ENSMUSP00000133045 | Probable G-protein coupled receptor 146; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | Protein lin-52 homolog. | 0.536 |
Gpr87 | Gpr107 | ENSMUSP00000143683 | ENSMUSP00000056739 | G-protein coupled receptor 87; Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage (By similarity). | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (By similarity). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | 0.471 |
Lin52 | Gpr107 | ENSMUSP00000133045 | ENSMUSP00000056739 | Protein lin-52 homolog. | Protein GPR107; Has been proposed to act as a receptor for neuronostatin, a peptide derived from the somatostatin/SST precursor (By similarity). Involved in blood sugar regulation through the induction of glucagon in response to low glucose (By similarity). | 0.454 |
Lin52 | Gpr146 | ENSMUSP00000133045 | ENSMUSP00000098083 | Protein lin-52 homolog. | Probable G-protein coupled receptor 146; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.536 |