node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Fgd6 | Ppm1n | ENSMUSP00000020208 | ENSMUSP00000032560 | FYVE, RhoGEF and PH domain-containing protein 6; May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). | Probable protein phosphatase 1N. | 0.591 |
Fgd6 | Pram1 | ENSMUSP00000020208 | ENSMUSP00000057065 | FYVE, RhoGEF and PH domain-containing protein 6; May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). | PML-RARA-regulated adapter molecule 1; May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P. | 0.553 |
Fgd6 | Tmem14a | ENSMUSP00000020208 | ENSMUSP00000027064 | FYVE, RhoGEF and PH domain-containing protein 6; May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). | Transmembrane protein 14A; Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; Belongs to the TMEM14 family. | 0.632 |
Gab2 | Lcp2 | ENSMUSP00000004622 | ENSMUSP00000056621 | GRB2-associated-binding protein 2; Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. Belongs to the GAB family. | Lymphocyte cytosolic protein 2; Involved in T-cell antigen receptor mediated signaling. | 0.708 |
Gab2 | Plcg2 | ENSMUSP00000004622 | ENSMUSP00000079991 | GRB2-associated-binding protein 2; Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. Belongs to the GAB family. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling (By similarity). | 0.960 |
Gab2 | Pram1 | ENSMUSP00000004622 | ENSMUSP00000057065 | GRB2-associated-binding protein 2; Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. Belongs to the GAB family. | PML-RARA-regulated adapter molecule 1; May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P. | 0.479 |
Gab2 | Skap2 | ENSMUSP00000004622 | ENSMUSP00000145462 | GRB2-associated-binding protein 2; Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. Belongs to the GAB family. | Src kinase-associated phosphoprotein 2; May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. Belongs to the SKAP family. | 0.447 |
Gab2 | Vav1 | ENSMUSP00000004622 | ENSMUSP00000005889 | GRB2-associated-binding protein 2; Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. Belongs to the GAB family. | Proto-oncogene vav; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. | 0.816 |
Lcp2 | Gab2 | ENSMUSP00000056621 | ENSMUSP00000004622 | Lymphocyte cytosolic protein 2; Involved in T-cell antigen receptor mediated signaling. | GRB2-associated-binding protein 2; Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. Belongs to the GAB family. | 0.708 |
Lcp2 | Plcg2 | ENSMUSP00000056621 | ENSMUSP00000079991 | Lymphocyte cytosolic protein 2; Involved in T-cell antigen receptor mediated signaling. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling (By similarity). | 0.997 |
Lcp2 | Pram1 | ENSMUSP00000056621 | ENSMUSP00000057065 | Lymphocyte cytosolic protein 2; Involved in T-cell antigen receptor mediated signaling. | PML-RARA-regulated adapter molecule 1; May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P. | 0.568 |
Lcp2 | Skap2 | ENSMUSP00000056621 | ENSMUSP00000145462 | Lymphocyte cytosolic protein 2; Involved in T-cell antigen receptor mediated signaling. | Src kinase-associated phosphoprotein 2; May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. Belongs to the SKAP family. | 0.771 |
Lcp2 | Vav1 | ENSMUSP00000056621 | ENSMUSP00000005889 | Lymphocyte cytosolic protein 2; Involved in T-cell antigen receptor mediated signaling. | Proto-oncogene vav; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. | 0.999 |
Lrrc66 | Pram1 | ENSMUSP00000084423 | ENSMUSP00000057065 | Leucine-rich repeat-containing protein 66. | PML-RARA-regulated adapter molecule 1; May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P. | 0.481 |
Plcg2 | Gab2 | ENSMUSP00000079991 | ENSMUSP00000004622 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling (By similarity). | GRB2-associated-binding protein 2; Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. Belongs to the GAB family. | 0.960 |
Plcg2 | Lcp2 | ENSMUSP00000079991 | ENSMUSP00000056621 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling (By similarity). | Lymphocyte cytosolic protein 2; Involved in T-cell antigen receptor mediated signaling. | 0.997 |
Plcg2 | Pram1 | ENSMUSP00000079991 | ENSMUSP00000057065 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling (By similarity). | PML-RARA-regulated adapter molecule 1; May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P. | 0.501 |
Plcg2 | Skap2 | ENSMUSP00000079991 | ENSMUSP00000145462 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling (By similarity). | Src kinase-associated phosphoprotein 2; May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. Belongs to the SKAP family. | 0.569 |
Plcg2 | Vav1 | ENSMUSP00000079991 | ENSMUSP00000005889 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling (By similarity). | Proto-oncogene vav; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. | 0.998 |
Ppm1n | Fgd6 | ENSMUSP00000032560 | ENSMUSP00000020208 | Probable protein phosphatase 1N. | FYVE, RhoGEF and PH domain-containing protein 6; May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity). | 0.591 |