STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Zfp574Zinc finger protein 574; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. (900 aa)    
Predicted Functional Partners:
Tomm40l
Mitochondrial import receptor subunit TOM40B; Potential channel-forming protein implicated in import of protein precursors into mitochondria.
      
 0.652
Ceacam16
Carcinoembryonic antigen-related cell adhesion molecule 16; Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane; Belongs to the immunoglobulin superfamily. CEA family.
    
 
 0.566
Cnfn
Cornifelin; Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
    
 
 0.561
Med26
Mediator of RNA polymerase II transcription subunit 26; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity).
   
 
 0.538
Trmt1l
TRMT1-like protein; May play a role in motor coordination and exploratory behavior; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
   
  
 0.534
Manbal
Protein MANBAL.
   
  
 0.533
Prr19
Proline-rich 19.
      
 0.529
Tmem145
Transmembrane protein 145.
      
 0.518
Ceacam18
Carcinoembryonic antigen-related cell adhesion molecule 18; Belongs to the immunoglobulin superfamily. CEA family.
    
 
 0.494
Pafah1b3
Platelet-activating factor acetylhydrolase IB subunit gamma; Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain; Belongs to the 'GDSL' lipolytic enzyme family. Platelet- activating factor acetylhydrolase IB beta/gamma subunits subfamily.
      
 0.493
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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