| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Atp13a5 | Hmx2 | ENSMUSP00000075204 | ENSMUSP00000058205 | Probable cation-transporting ATPase 13A5; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | Homeobox protein HMX2; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. | 0.486 |
| Bcl6b | Hmx2 | ENSMUSP00000000326 | ENSMUSP00000058205 | B-cell CLL/lymphoma 6 member B protein; Acts as a sequence-specific transcriptional repressor in association with BCL6. Necessary for activation of naive T-cells to antigenic stimulation. May attenuate the regulatory effect of BCL6 on antigenic activation of naive CD4 T-cells by forming a heterodimer with BCL6. | Homeobox protein HMX2; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. | 0.443 |
| Bcl6b | Hoxa11 | ENSMUSP00000000326 | ENSMUSP00000040920 | B-cell CLL/lymphoma 6 member B protein; Acts as a sequence-specific transcriptional repressor in association with BCL6. Necessary for activation of naive T-cells to antigenic stimulation. May attenuate the regulatory effect of BCL6 on antigenic activation of naive CD4 T-cells by forming a heterodimer with BCL6. | Homeobox protein Hox-A11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. | 0.404 |
| Bcl6b | Pou3f1 | ENSMUSP00000000326 | ENSMUSP00000137374 | B-cell CLL/lymphoma 6 member B protein; Acts as a sequence-specific transcriptional repressor in association with BCL6. Necessary for activation of naive T-cells to antigenic stimulation. May attenuate the regulatory effect of BCL6 on antigenic activation of naive CD4 T-cells by forming a heterodimer with BCL6. | POU domain, class 3, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Thought to be involved in early embryogenesis and neurogenesis. | 0.456 |
| Bcl6b | Zic2 | ENSMUSP00000000326 | ENSMUSP00000075283 | B-cell CLL/lymphoma 6 member B protein; Acts as a sequence-specific transcriptional repressor in association with BCL6. Necessary for activation of naive T-cells to antigenic stimulation. May attenuate the regulatory effect of BCL6 on antigenic activation of naive CD4 T-cells by forming a heterodimer with BCL6. | Zinc finger protein ZIC 2; Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye- specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5' [...] | 0.408 |
| Bub3 | Hmx2 | ENSMUSP00000081547 | ENSMUSP00000058205 | Mitotic checkpoint protein BUB3; Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1 (By similarity [...] | Homeobox protein HMX2; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. | 0.575 |
| Foxi3 | Hmx2 | ENSMUSP00000065664 | ENSMUSP00000058205 | Forkhead box I3. | Homeobox protein HMX2; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. | 0.521 |
| Hmx2 | Atp13a5 | ENSMUSP00000058205 | ENSMUSP00000075204 | Homeobox protein HMX2; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. | Probable cation-transporting ATPase 13A5; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | 0.486 |
| Hmx2 | Bcl6b | ENSMUSP00000058205 | ENSMUSP00000000326 | Homeobox protein HMX2; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. | B-cell CLL/lymphoma 6 member B protein; Acts as a sequence-specific transcriptional repressor in association with BCL6. Necessary for activation of naive T-cells to antigenic stimulation. May attenuate the regulatory effect of BCL6 on antigenic activation of naive CD4 T-cells by forming a heterodimer with BCL6. | 0.443 |
| Hmx2 | Bub3 | ENSMUSP00000058205 | ENSMUSP00000081547 | Homeobox protein HMX2; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. | Mitotic checkpoint protein BUB3; Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1 (By similarity [...] | 0.575 |
| Hmx2 | Foxi3 | ENSMUSP00000058205 | ENSMUSP00000065664 | Homeobox protein HMX2; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. | Forkhead box I3. | 0.521 |
| Hmx2 | Hoxa11 | ENSMUSP00000058205 | ENSMUSP00000040920 | Homeobox protein HMX2; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. | Homeobox protein Hox-A11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. | 0.481 |
| Hmx2 | Insm2 | ENSMUSP00000058205 | ENSMUSP00000061046 | Homeobox protein HMX2; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. | Insulinoma-associated protein 2; May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons. | 0.539 |
| Hmx2 | Nfe2l3 | ENSMUSP00000058205 | ENSMUSP00000005103 | Homeobox protein HMX2; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. | Nuclear factor erythroid 2-related factor 3; Activates erythroid-specific, globin gene expression; Belongs to the bZIP family. CNC subfamily. | 0.476 |
| Hmx2 | Pou3f1 | ENSMUSP00000058205 | ENSMUSP00000137374 | Homeobox protein HMX2; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. | POU domain, class 3, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Thought to be involved in early embryogenesis and neurogenesis. | 0.513 |
| Hmx2 | Wnk2 | ENSMUSP00000058205 | ENSMUSP00000089212 | Homeobox protein HMX2; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. | Serine/threonine-protein kinase WNK2; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulatio [...] | 0.494 |
| Hmx2 | Zic2 | ENSMUSP00000058205 | ENSMUSP00000075283 | Homeobox protein HMX2; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. | Zinc finger protein ZIC 2; Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye- specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5' [...] | 0.467 |
| Hoxa11 | Bcl6b | ENSMUSP00000040920 | ENSMUSP00000000326 | Homeobox protein Hox-A11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. | B-cell CLL/lymphoma 6 member B protein; Acts as a sequence-specific transcriptional repressor in association with BCL6. Necessary for activation of naive T-cells to antigenic stimulation. May attenuate the regulatory effect of BCL6 on antigenic activation of naive CD4 T-cells by forming a heterodimer with BCL6. | 0.404 |
| Hoxa11 | Hmx2 | ENSMUSP00000040920 | ENSMUSP00000058205 | Homeobox protein Hox-A11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. | Homeobox protein HMX2; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. | 0.481 |
| Hoxa11 | Nfe2l3 | ENSMUSP00000040920 | ENSMUSP00000005103 | Homeobox protein Hox-A11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. | Nuclear factor erythroid 2-related factor 3; Activates erythroid-specific, globin gene expression; Belongs to the bZIP family. CNC subfamily. | 0.479 |
STRING v12.5 is now available!
