node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Creg2 | Sfxn3 | ENSMUSP00000052871 | ENSMUSP00000059419 | Protein CREG2; Belongs to the CREG family. | Sideroflexin-3; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Belongs to the sideroflexin family. | 0.514 |
Creg2 | Srek1ip1 | ENSMUSP00000052871 | ENSMUSP00000022230 | Protein CREG2; Belongs to the CREG family. | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival. | 0.634 |
Htt | Sfxn3 | ENSMUSP00000078945 | ENSMUSP00000059419 | Huntingtin, myristoylated N-terminal fragment; [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function. | Sideroflexin-3; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Belongs to the sideroflexin family. | 0.511 |
Rpp14 | Sfxn3 | ENSMUSP00000023924 | ENSMUSP00000059419 | Ribonuclease P protein subunit p14; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Belongs to the eukaryotic/archaeal RNase P protein component 2 family. | Sideroflexin-3; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Belongs to the sideroflexin family. | 0.422 |
Runx1t1 | Sfxn3 | ENSMUSP00000127109 | ENSMUSP00000059419 | Protein CBFA2T1; Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Can repress transactivation mediated by TCF12 (By similarity). Acts as a negative regulator of adipogenesis. | Sideroflexin-3; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Belongs to the sideroflexin family. | 0.476 |
Sfxn3 | Creg2 | ENSMUSP00000059419 | ENSMUSP00000052871 | Sideroflexin-3; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Belongs to the sideroflexin family. | Protein CREG2; Belongs to the CREG family. | 0.514 |
Sfxn3 | Htt | ENSMUSP00000059419 | ENSMUSP00000078945 | Sideroflexin-3; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Belongs to the sideroflexin family. | Huntingtin, myristoylated N-terminal fragment; [Huntingtin]: May play a role in microtubule-mediated transport or vesicle function. | 0.511 |
Sfxn3 | Rpp14 | ENSMUSP00000059419 | ENSMUSP00000023924 | Sideroflexin-3; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Belongs to the sideroflexin family. | Ribonuclease P protein subunit p14; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Belongs to the eukaryotic/archaeal RNase P protein component 2 family. | 0.422 |
Sfxn3 | Runx1t1 | ENSMUSP00000059419 | ENSMUSP00000127109 | Sideroflexin-3; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Belongs to the sideroflexin family. | Protein CBFA2T1; Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Can repress transactivation mediated by TCF12 (By similarity). Acts as a negative regulator of adipogenesis. | 0.476 |
Sfxn3 | Slc25a38 | ENSMUSP00000059419 | ENSMUSP00000035106 | Sideroflexin-3; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Belongs to the sideroflexin family. | Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis. Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. | 0.487 |
Sfxn3 | Srek1ip1 | ENSMUSP00000059419 | ENSMUSP00000022230 | Sideroflexin-3; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Belongs to the sideroflexin family. | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival. | 0.489 |
Sfxn3 | Stox2 | ENSMUSP00000059419 | ENSMUSP00000078190 | Sideroflexin-3; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Belongs to the sideroflexin family. | Storkhead-box protein 2. | 0.414 |
Slc25a38 | Sfxn3 | ENSMUSP00000035106 | ENSMUSP00000059419 | Mitochondrial glycine transporter; Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis. Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. | Sideroflexin-3; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Belongs to the sideroflexin family. | 0.487 |
Srek1ip1 | Creg2 | ENSMUSP00000022230 | ENSMUSP00000052871 | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival. | Protein CREG2; Belongs to the CREG family. | 0.634 |
Srek1ip1 | Sfxn3 | ENSMUSP00000022230 | ENSMUSP00000059419 | Protein SREK1IP1; Possible splicing regulator involved in the control of cellular survival. | Sideroflexin-3; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Belongs to the sideroflexin family. | 0.489 |
Stox2 | Sfxn3 | ENSMUSP00000078190 | ENSMUSP00000059419 | Storkhead-box protein 2. | Sideroflexin-3; Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors. Belongs to the sideroflexin family. | 0.414 |