node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cfap58 | Cyb5d1 | ENSMUSP00000070533 | ENSMUSP00000059709 | Cilia- and flagella-associated protein 58. | Cytochrome b5 domain-containing protein 1. | 0.507 |
Cyb5d1 | Cfap58 | ENSMUSP00000059709 | ENSMUSP00000070533 | Cytochrome b5 domain-containing protein 1. | Cilia- and flagella-associated protein 58. | 0.507 |
Cyb5d1 | Cyb5r4 | ENSMUSP00000059709 | ENSMUSP00000126119 | Cytochrome b5 domain-containing protein 1. | Cytochrome b5 reductase 4; NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). | 0.663 |
Cyb5d1 | Dnajc24 | ENSMUSP00000059709 | ENSMUSP00000099615 | Cytochrome b5 domain-containing protein 1. | DnaJ homolog subfamily C member 24; The iron-bound form is redox-active and can function as electron carrier (By similarity). Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron- binding. Plays a role in the diphthamide biosynthesis, a post- translational modification of histidine which occurs in translation elongation factor 2 (EEF2). | 0.568 |
Cyb5d1 | Dnajc3 | ENSMUSP00000059709 | ENSMUSP00000022734 | Cytochrome b5 domain-containing protein 1. | DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF- 2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activi [...] | 0.546 |
Cyb5d1 | Dnali1 | ENSMUSP00000059709 | ENSMUSP00000047783 | Cytochrome b5 domain-containing protein 1. | Axonemal dynein light intermediate polypeptide 1; May play a dynamic role in flagellar motility; Belongs to the inner dynein arm light chain family. | 0.693 |
Cyb5d1 | Edar | ENSMUSP00000059709 | ENSMUSP00000003312 | Cytochrome b5 domain-containing protein 1. | Tumor necrosis factor receptor superfamily member EDAR; Receptor for EDA isoform TAA, but not for EDA isoform TA-2 (By similarity). May mediate the activation of NF-kappa-B and JNK. May promote caspase-independent cell death. | 0.546 |
Cyb5d1 | Mrps31 | ENSMUSP00000059709 | ENSMUSP00000033934 | Cytochrome b5 domain-containing protein 1. | 28S ribosomal protein S31, mitochondrial; Belongs to the mitochondrion-specific ribosomal protein mS31 family. | 0.602 |
Cyb5d1 | Slc4a8 | ENSMUSP00000059709 | ENSMUSP00000023776 | Cytochrome b5 domain-containing protein 1. | Electroneutral sodium bicarbonate exchanger 1; Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity. | 0.592 |
Cyb5d1 | Suox | ENSMUSP00000059709 | ENSMUSP00000056195 | Cytochrome b5 domain-containing protein 1. | Sulfite oxidase, mitochondrial. | 0.661 |
Cyb5d1 | Tekt1 | ENSMUSP00000059709 | ENSMUSP00000021155 | Cytochrome b5 domain-containing protein 1. | Tektin-1; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity). | 0.558 |
Cyb5r4 | Cyb5d1 | ENSMUSP00000126119 | ENSMUSP00000059709 | Cytochrome b5 reductase 4; NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). | Cytochrome b5 domain-containing protein 1. | 0.663 |
Cyb5r4 | Suox | ENSMUSP00000126119 | ENSMUSP00000056195 | Cytochrome b5 reductase 4; NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). | Sulfite oxidase, mitochondrial. | 0.657 |
Dnajc24 | Cyb5d1 | ENSMUSP00000099615 | ENSMUSP00000059709 | DnaJ homolog subfamily C member 24; The iron-bound form is redox-active and can function as electron carrier (By similarity). Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron- binding. Plays a role in the diphthamide biosynthesis, a post- translational modification of histidine which occurs in translation elongation factor 2 (EEF2). | Cytochrome b5 domain-containing protein 1. | 0.568 |
Dnajc24 | Dnajc3 | ENSMUSP00000099615 | ENSMUSP00000022734 | DnaJ homolog subfamily C member 24; The iron-bound form is redox-active and can function as electron carrier (By similarity). Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron- binding. Plays a role in the diphthamide biosynthesis, a post- translational modification of histidine which occurs in translation elongation factor 2 (EEF2). | DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF- 2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activi [...] | 0.403 |
Dnajc3 | Cyb5d1 | ENSMUSP00000022734 | ENSMUSP00000059709 | DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF- 2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activi [...] | Cytochrome b5 domain-containing protein 1. | 0.546 |
Dnajc3 | Dnajc24 | ENSMUSP00000022734 | ENSMUSP00000099615 | DnaJ homolog subfamily C member 3; Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF- 2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activi [...] | DnaJ homolog subfamily C member 24; The iron-bound form is redox-active and can function as electron carrier (By similarity). Stimulates the ATPase activity of several Hsp70-type chaperones. This ability is enhanced by iron- binding. Plays a role in the diphthamide biosynthesis, a post- translational modification of histidine which occurs in translation elongation factor 2 (EEF2). | 0.403 |
Dnali1 | Cyb5d1 | ENSMUSP00000047783 | ENSMUSP00000059709 | Axonemal dynein light intermediate polypeptide 1; May play a dynamic role in flagellar motility; Belongs to the inner dynein arm light chain family. | Cytochrome b5 domain-containing protein 1. | 0.693 |
Dnali1 | Slc4a8 | ENSMUSP00000047783 | ENSMUSP00000023776 | Axonemal dynein light intermediate polypeptide 1; May play a dynamic role in flagellar motility; Belongs to the inner dynein arm light chain family. | Electroneutral sodium bicarbonate exchanger 1; Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity. | 0.589 |
Dnali1 | Tekt1 | ENSMUSP00000047783 | ENSMUSP00000021155 | Axonemal dynein light intermediate polypeptide 1; May play a dynamic role in flagellar motility; Belongs to the inner dynein arm light chain family. | Tektin-1; Structural component of ciliary and flagellar microtubules. Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity). | 0.654 |