node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ambn | Amelx | ENSMUSP00000142944 | ENSMUSP00000065966 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | 0.992 |
Ambn | Amtn | ENSMUSP00000142944 | ENSMUSP00000073081 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Amelotin; Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis. Belongs to the amelotin family. | 0.961 |
Ambn | Col17a1 | ENSMUSP00000142944 | ENSMUSP00000026045 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | 120 kDa linear IgA disease antigen homolog; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. | 0.458 |
Ambn | Enam | ENSMUSP00000142944 | ENSMUSP00000031222 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. | 0.991 |
Ambn | Fam20a | ENSMUSP00000142944 | ENSMUSP00000020938 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals. | 0.794 |
Ambn | Fam83h | ENSMUSP00000142944 | ENSMUSP00000126453 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Protein FAM83H; May play a major role in the structural organization and calcification of developing enamel. May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration. Belongs to the FAM83 family. | 0.703 |
Ambn | Klk1b4 | ENSMUSP00000142944 | ENSMUSP00000076576 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Kallikrein 1-related peptidase-like b4. | 0.792 |
Ambn | Klk4 | ENSMUSP00000142944 | ENSMUSP00000007161 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Kallikrein-4; Has a major role in enamel formation. Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix. | 0.874 |
Ambn | Slc24a4 | ENSMUSP00000142944 | ENSMUSP00000157352 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | Sodium/potassium/calcium exchanger 4; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis. | 0.585 |
Ambn | Wdr72 | ENSMUSP00000142944 | ENSMUSP00000057320 | Ameloblastin; Involved in the mineralization and structural organization of enamel. | WD repeat-containing protein 72; Plays a major role in formation of tooth enamel. Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane. | 0.687 |
Amelx | Ambn | ENSMUSP00000065966 | ENSMUSP00000142944 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Ameloblastin; Involved in the mineralization and structural organization of enamel. | 0.992 |
Amelx | Amtn | ENSMUSP00000065966 | ENSMUSP00000073081 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Amelotin; Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis. Belongs to the amelotin family. | 0.911 |
Amelx | Col17a1 | ENSMUSP00000065966 | ENSMUSP00000026045 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | 120 kDa linear IgA disease antigen homolog; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. | 0.429 |
Amelx | Enam | ENSMUSP00000065966 | ENSMUSP00000031222 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Enamelin; Involved in the mineralization and structural organization of enamel. Involved in the extension of enamel during the secretory stage of dental enamel formation. | 0.990 |
Amelx | Fam20a | ENSMUSP00000065966 | ENSMUSP00000020938 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Pseudokinase FAM20A; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals. | 0.782 |
Amelx | Fam83h | ENSMUSP00000065966 | ENSMUSP00000126453 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Protein FAM83H; May play a major role in the structural organization and calcification of developing enamel. May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration. Belongs to the FAM83 family. | 0.810 |
Amelx | Klk1b4 | ENSMUSP00000065966 | ENSMUSP00000076576 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Kallikrein 1-related peptidase-like b4. | 0.802 |
Amelx | Klk4 | ENSMUSP00000065966 | ENSMUSP00000007161 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Kallikrein-4; Has a major role in enamel formation. Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix. | 0.917 |
Amelx | Slc24a4 | ENSMUSP00000065966 | ENSMUSP00000157352 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | Sodium/potassium/calcium exchanger 4; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis. | 0.620 |
Amelx | Wdr72 | ENSMUSP00000065966 | ENSMUSP00000057320 | Amelogenin, X isoform; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. | WD repeat-containing protein 72; Plays a major role in formation of tooth enamel. Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane. | 0.739 |