node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arhgef25 | Mylk4 | ENSMUSP00000019611 | ENSMUSP00000060149 | Rho guanine nucleotide exchange factor 25; May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation (By similarity). May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis. | Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.445 |
Ciart | Mylk4 | ENSMUSP00000124943 | ENSMUSP00000060149 | Circadian-associated transcriptional repressor; Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK- ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. [...] | Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.416 |
Kalrn | Mylk4 | ENSMUSP00000110611 | ENSMUSP00000060149 | Kalirin; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.551 |
Mybpc1 | Myl3 | ENSMUSP00000112699 | ENSMUSP00000078715 | Myosin-binding protein C, slow-type. | Myosin light chain 3; Regulatory light chain of myosin. Does not bind calcium. | 0.680 |
Mybpc1 | Mylk4 | ENSMUSP00000112699 | ENSMUSP00000060149 | Myosin-binding protein C, slow-type. | Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.428 |
Mybpc1 | Myoz2 | ENSMUSP00000112699 | ENSMUSP00000029761 | Myosin-binding protein C, slow-type. | Myozenin-2; Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. | 0.505 |
Mybph | Mylk4 | ENSMUSP00000141104 | ENSMUSP00000060149 | Myosin-binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band; Belongs to the immunoglobulin superfamily. MyBP family. | Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.717 |
Myl3 | Mybpc1 | ENSMUSP00000078715 | ENSMUSP00000112699 | Myosin light chain 3; Regulatory light chain of myosin. Does not bind calcium. | Myosin-binding protein C, slow-type. | 0.680 |
Myl3 | Myl6b | ENSMUSP00000078715 | ENSMUSP00000026428 | Myosin light chain 3; Regulatory light chain of myosin. Does not bind calcium. | Myosin light chain 6B; Regulatory light chain of myosin. Does not bind calcium. | 0.569 |
Myl3 | Mylk4 | ENSMUSP00000078715 | ENSMUSP00000060149 | Myosin light chain 3; Regulatory light chain of myosin. Does not bind calcium. | Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.464 |
Myl3 | Myoz2 | ENSMUSP00000078715 | ENSMUSP00000029761 | Myosin light chain 3; Regulatory light chain of myosin. Does not bind calcium. | Myozenin-2; Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. | 0.894 |
Myl6b | Myl3 | ENSMUSP00000026428 | ENSMUSP00000078715 | Myosin light chain 6B; Regulatory light chain of myosin. Does not bind calcium. | Myosin light chain 3; Regulatory light chain of myosin. Does not bind calcium. | 0.569 |
Myl6b | Mylk4 | ENSMUSP00000026428 | ENSMUSP00000060149 | Myosin light chain 6B; Regulatory light chain of myosin. Does not bind calcium. | Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.472 |
Myl6b | Myoz2 | ENSMUSP00000026428 | ENSMUSP00000029761 | Myosin light chain 6B; Regulatory light chain of myosin. Does not bind calcium. | Myozenin-2; Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. | 0.454 |
Mylk4 | Arhgef25 | ENSMUSP00000060149 | ENSMUSP00000019611 | Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | Rho guanine nucleotide exchange factor 25; May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation (By similarity). May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis. | 0.445 |
Mylk4 | Ciart | ENSMUSP00000060149 | ENSMUSP00000124943 | Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | Circadian-associated transcriptional repressor; Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK- ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. [...] | 0.416 |
Mylk4 | Kalrn | ENSMUSP00000060149 | ENSMUSP00000110611 | Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | Kalirin; Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.551 |
Mylk4 | Mybpc1 | ENSMUSP00000060149 | ENSMUSP00000112699 | Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | Myosin-binding protein C, slow-type. | 0.428 |
Mylk4 | Mybph | ENSMUSP00000060149 | ENSMUSP00000141104 | Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | Myosin-binding protein H; Binds to myosin; probably involved in interaction with thick myofilaments in the A-band; Belongs to the immunoglobulin superfamily. MyBP family. | 0.717 |
Mylk4 | Myl3 | ENSMUSP00000060149 | ENSMUSP00000078715 | Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | Myosin light chain 3; Regulatory light chain of myosin. Does not bind calcium. | 0.464 |