| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Calml4 | Mylk | ENSMUSP00000034777 | ENSMUSP00000023538 | Calmodulin-like protein 4. | Myosin light chain kinase, smooth muscle, deglutamylated form; Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessa [...] | 0.941 |
| Calml4 | Mylk4 | ENSMUSP00000034777 | ENSMUSP00000060149 | Calmodulin-like protein 4. | Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.897 |
| Myl10 | Myl2 | ENSMUSP00000005611 | ENSMUSP00000107380 | Myosin regulatory light chain 10. | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function. Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites t [...] | 0.913 |
| Myl10 | Myl3 | ENSMUSP00000005611 | ENSMUSP00000078715 | Myosin regulatory light chain 10. | Myosin light chain 3; Regulatory light chain of myosin. Does not bind calcium. | 0.749 |
| Myl10 | Myl4 | ENSMUSP00000005611 | ENSMUSP00000102570 | Myosin regulatory light chain 10. | Myosin light chain 4; Regulatory light chain of myosin. Does not bind calcium. | 0.766 |
| Myl10 | Myl6b | ENSMUSP00000005611 | ENSMUSP00000026428 | Myosin regulatory light chain 10. | Myosin light chain 6B; Regulatory light chain of myosin. Does not bind calcium. | 0.891 |
| Myl10 | Myl7 | ENSMUSP00000005611 | ENSMUSP00000099985 | Myosin regulatory light chain 10. | Myosin regulatory light chain 2, atrial isoform. | 0.654 |
| Myl10 | Myl9 | ENSMUSP00000005611 | ENSMUSP00000085913 | Myosin regulatory light chain 10. | Myosin regulatory light polypeptide 9; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. | 0.755 |
| Myl10 | Mylk | ENSMUSP00000005611 | ENSMUSP00000023538 | Myosin regulatory light chain 10. | Myosin light chain kinase, smooth muscle, deglutamylated form; Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessa [...] | 0.939 |
| Myl10 | Mylk4 | ENSMUSP00000005611 | ENSMUSP00000060149 | Myosin regulatory light chain 10. | Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.902 |
| Myl10 | Mylpf | ENSMUSP00000005611 | ENSMUSP00000032910 | Myosin regulatory light chain 10. | Myosin regulatory light chain 2, skeletal muscle isoform. | 0.743 |
| Myl2 | Myl10 | ENSMUSP00000107380 | ENSMUSP00000005611 | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function. Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites t [...] | Myosin regulatory light chain 10. | 0.913 |
| Myl2 | Myl3 | ENSMUSP00000107380 | ENSMUSP00000078715 | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function. Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites t [...] | Myosin light chain 3; Regulatory light chain of myosin. Does not bind calcium. | 0.999 |
| Myl2 | Myl4 | ENSMUSP00000107380 | ENSMUSP00000102570 | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function. Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites t [...] | Myosin light chain 4; Regulatory light chain of myosin. Does not bind calcium. | 0.974 |
| Myl2 | Myl6b | ENSMUSP00000107380 | ENSMUSP00000026428 | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function. Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites t [...] | Myosin light chain 6B; Regulatory light chain of myosin. Does not bind calcium. | 0.905 |
| Myl2 | Myl7 | ENSMUSP00000107380 | ENSMUSP00000099985 | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function. Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites t [...] | Myosin regulatory light chain 2, atrial isoform. | 0.470 |
| Myl2 | Myl9 | ENSMUSP00000107380 | ENSMUSP00000085913 | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function. Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites t [...] | Myosin regulatory light polypeptide 9; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. | 0.877 |
| Myl2 | Mylk | ENSMUSP00000107380 | ENSMUSP00000023538 | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function. Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites t [...] | Myosin light chain kinase, smooth muscle, deglutamylated form; Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessa [...] | 0.951 |
| Myl2 | Mylk4 | ENSMUSP00000107380 | ENSMUSP00000060149 | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function. Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites t [...] | Myosin light chain kinase family member 4; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.911 |
| Myl2 | Mylpf | ENSMUSP00000107380 | ENSMUSP00000032910 | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; Contractile protein that plays a role in heart development and function. Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites t [...] | Myosin regulatory light chain 2, skeletal muscle isoform. | 0.853 |
