STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Defb6Beta-defensin 6; Has potent antibacterial activity against E.coli (ATCC 25922); Belongs to the beta-defensin family. (63 aa)    
Predicted Functional Partners:
Defb19
Beta-defensin 19; Has antibacterial activity; Belongs to the beta-defensin family.
      
 0.584
Defb1
Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family.
   
  
 0.582
Defb15
Beta-defensin 15; Has antibacterial activity.
      
 0.555
Defb14
Beta-defensin 14; Has antibacterial activity; Belongs to the beta-defensin family.
   
  
 0.548
Defb45
Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.
      
 0.535
Sdr16c6
Short-chain dehydrogenase/reductase family 16C member 6; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
    0.418
Defb36
Beta-defensin 36; Has antibacterial activity; Belongs to the beta-defensin family.
      
 0.416
Defb2
Beta-defensin 2; Has bactericidal activity; Belongs to the beta-defensin family.
   
  
 0.409
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.