STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Defb13Beta-defensin 13; Has antibacterial activity. (64 aa)    
Predicted Functional Partners:
Defb35
Beta-defensin 35; Has antibacterial activity.
   
  
 0.844
Defb15
Beta-defensin 15; Has antibacterial activity.
   
  
 0.773
Defb1
Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility; Belongs to the beta-defensin family.
      
 0.727
Defb10
Beta-defensin 10; Has antibacterial activity.
   
  
 0.727
Defb12
Beta-defensin 12; Has antibacterial activity.
   
  
 0.692
Defb33
Beta-defensin 33; Has antibacterial activity; Belongs to the beta-defensin family.
      
 0.676
Defb28
Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.
   
  
 0.641
Defb22
Beta-defensin 22; Probable component of sperm glycocalyx. Likely protects and facilitates transport of sperm in the female reproductive tract. Probably released from the sperm surface during capacitation. Belongs to the beta-defensin family.
   
  
 0.636
Defb5
Beta-defensin 5; Has antibacterial activity; Belongs to the beta-defensin family.
   
  
 0.617
Gm45826
Sperm-associated antigen 11; May have antimicrobial activity. May also play a role sperm maturation, storage, and protection.
      
 0.605
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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